Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment

Nanoscale ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 4855-4870
Author(s):  
Qifang Chen ◽  
Xianbin Ma ◽  
Li Xie ◽  
Wenjie Chen ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mr Imaging ◽  
Cancer Treatment ◽  
Antitumor Effects ◽  
Therapy Strategy ◽  
Intracellular Ros ◽  
Iron Based

MR imaging-guided a synergistic ferroptosis-photodynamic therapy strategy can enhance antitumor effects by accumulating intracellular ROS through the utilization of iron-based nanoparticles.

Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

2020 ◽  
Vol 49 (33) ◽  
pp. 11583-11590 ◽  
Author(s):  
Zheng-Yin Pan ◽  
Dai-Hong Cai ◽  
Liang He
Keyword(s):  
Photodynamic Therapy ◽  
Cell Apoptosis ◽  
Lysosomal Dysfunction ◽  
Intracellular Ros

Two dinuclear organometallic Re(i) complexes increase intracellular ROS levels, causing lysosomal dysfunction and cell apoptosis.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

MnO2 nanoflowers as a multifunctional nano-platform for enhanced photothermal/photodynamic therapy and MR imaging

2021 ◽  
Author(s):  
Wanru Sun ◽  
Hui Yu ◽  
Deqiang Wang ◽  
Youjie Li ◽  
Baocheng Tian ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mr Imaging ◽  
Manganese Oxide ◽  
Oxide Nanoparticles ◽  
Manganese Oxide Nanoparticles

Well-defined flower-shaped manganese oxide nanoparticles modified with 3-aminopropyltriethoxysilane (APTES) and loaded with Ce6 were achieved to realize synergistic PDT/PTT therapy and MR imaging.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

scholarly journals Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Izumi Kirino ◽  
Katsuhiko Fujita ◽  
Kei Sakanoue ◽  
Rin Sugita ◽  
Kento Yamagishi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Antitumor Effects ◽  
Continuous Irradiation ◽  
Cancer Cell Death ◽  
Long Duration ◽  
Green Led ◽  
Repeated Administrations ◽  
532 Nm ◽  
Patient Burden

AbstractMetronomic photodynamic therapy (mPDT) is a form of PDT that induces cancer cell death by intermittent continuous irradiation with a relatively weak power of light for a long duration (several days). We previously developed a wirelessly powered, fully implantable LED device and reported a significant anti-tumor effect of mPDT. Considering application in clinical practice, the method used for repeated administrations of photosensitizers required for mPDT should not have a high patient burden such as the burden of transvenous administration. Therefore, in this study, we selected 5-aminolevulinic acid (ALA), which can be administered orally, as a photosensitizer, and we studied the antitumor effects of mPDT. In mice with intradermal tumors that were orally administered ALA (200 mg/kg daily for 5 days), the tumor in each mouse was simultaneously irradiated (8 h/day for 5 days) using a wirelessly powered implantable green LED device (532 nm, 0.05 mW). Tumor growth in the mPDT-treated mice was suppressed by about half compared to that in untreated mice. The results showed that mPDT using the wirelessly powered implantable LED device exerted an antitumor effect even with the use of orally administered ALA, and this treatment scheme can reduce the burden of photosensitizer administration for a patient.

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduce into CO in living cells for hypoxia tumor treatment

2021 ◽  
Author(s):  
Endong Zhang ◽  
Zicheng Zuo ◽  
Wen Yu ◽  
Hao Zhao ◽  
Shengpeng Xia ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Conjugated Polymer ◽  
Tumor Therapy ◽  
Living Cells ◽  
Tumor Treatment ◽  
Treatment Efficiency ◽  
Therapy Strategy ◽  
Co Gas

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

scholarly journals Celecoxib Analogues for Cancer Treatment: An Update on OSU-03012 and 2,5-Dimethyl-Celecoxib

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1049
Author(s):  
Cyril Sobolewski ◽  
Noémie Legrand
Keyword(s):  
Cancer Treatment ◽  
Metabolic Diseases ◽  
Catalytic Site ◽  
Antitumor Effects ◽  
Anti Cancer ◽  
Cox 2 ◽  
Cox 2 Inhibitors ◽  
The Impact ◽  
Important Enzyme ◽  
Specific Inhibitors

Cyclooxygenase-2 (COX-2) is an important enzyme involved in prostaglandins biosynthesis from arachidonic acid. COX-2 is frequently overexpressed in human cancers and plays a major tumor promoting function. Accordingly, many efforts have been devoted to efficiently target the catalytic site of this enzyme in cancer cells, by using COX-2 specific inhibitors such as celecoxib. However, despite their potent anti-tumor properties, the myriad of detrimental effects associated to the chronic inhibition of COX-2 in healthy tissues, has considerably limited their use in clinic. In addition, increasing evidence indicate that these anti-cancerous properties are not strictly dependent on the inhibition of the catalytic site. These findings have led to the development of non-active COX-2 inhibitors analogues aiming at preserving the antitumor effects of COX-2 inhibitors without their side effects. Among them, two celecoxib derivatives, 2,5-Dimethyl-Celecoxib and OSU-03012, have been developed and suggested for the treatment of viral (e.g., recently SARS-CoV-2), inflammatory, metabolic diseases and cancers. These molecules display stronger anti-tumor properties than celecoxib and thus may represent promising anti-cancer molecules. In this review, we discuss the impact of these two analogues on cancerous processes but also their potential for cancer treatment alone or in combination with existing approaches.

TNF‐α in Cancer Treatment: Molecular Insights, Antitumor Effects, and Clinical Utility

2006 ◽  
Vol 11 (4) ◽  
pp. 397-408 ◽  
Author(s):  
Remco van Horssen ◽  
Timo L. M. ten Hagen ◽  
Alexander M. M. Eggermont
Keyword(s):  
Cancer Treatment ◽  
Clinical Utility ◽  
Antitumor Effects ◽  
Tnf Α

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

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