Bio-inspired lubricant drug delivery particles for the treatment of osteoarthritis

Nanoscale ◽  
2020 ◽  
Vol 12 (32) ◽  
pp. 17093-17102
Author(s):  
Lei Yang ◽  
Yuxiao Liu ◽  
Xin Shou ◽  
Dong Ni ◽  
Tiantian Kong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Osteoarthritis Treatment

Bio-inspired lubricant drug delivery particles can be used for osteoarthritis treatment.

Ice-Inspired Lubricated Drug Delivery Particles from Microfluidic Electrospray for Osteoarthritis Treatment

ACS Nano ◽  
2021 ◽  
Author(s):  
Lei Yang ◽  
Lingyu Sun ◽  
Han Zhang ◽  
Feika Bian ◽  
Yuanjin Zhao
Keyword(s):  
Drug Delivery ◽  
Osteoarthritis Treatment

Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

Nanoscale ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 6394-6399 ◽  
Author(s):  
Weiwei Zhao ◽  
Hua Wang ◽  
Haimang Wang ◽  
Ying Han ◽  
Zhibo Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Visible Light ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Dual Functional ◽  
Osteoarthritis Treatment ◽  
Anti Inflammation

Visible light-responsive biodegradable mesoporous silica nanoparticles (bMSNs-AZO/CD-PMPC) were developed for osteoarthritis treatment, which simultaneously achieved lubrication enhancement and anti-inflammation.

scholarly journals Intra-Articular Drug Delivery for Osteoarthritis Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2166
Author(s):  
Yifeng Cao ◽  
Yifeng Ma ◽  
Yi Tao ◽  
Weifeng Lin ◽  
Ping Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Degenerative Joint Disease ◽  
Delivery Systems ◽  
Nano Particles ◽  
Joint Disease ◽  
High Concentration ◽  
Efficient Treatment ◽  
Osteoarthritis Treatment ◽  
Prolonged Retention

Osteoarthritis (OA) is the most prevalent degenerative joint disease affecting millions of people worldwide. Currently, clinical nonsurgical treatments of OA are only limited to pain relief, anti-inflammation, and viscosupplementation. Developing disease-modifying OA drugs (DMOADs) is highly demanded for the efficient treatment of OA. As OA is a local disease, intra-articular (IA) injection directly delivers drugs to synovial joints, resulting in high-concentration drugs in the joint and reduced side effects, accompanied with traditional oral or topical administrations. However, the injected drugs are rapidly cleaved. By properly designing the drug delivery systems, prolonged retention time and targeting could be obtained. In this review, we summarize the drugs investigated for OA treatment and recent advances in the IA drug delivery systems, including micro- and nano-particles, liposomes, and hydrogels, hoping to provide some information for designing the IA injected formulations.

scholarly journals Drug delivery systems for Intra⁃articular injection in the Osteoarthritis treatment

2020 ◽  
Keyword(s):  
Drug Delivery ◽  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Toxic Effect ◽  
Drug Administration ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Development ◽  
Osteoarthritis Treatment

Intra⁃articular injection is one of the most important treatment for osteoarthritis (OA) drug administration. It would improve the pharmacotherapy efficacy and reduce the adverse drug reaction and toxic effect of drugs. In the last decades, the microspheres, nanoparticles, hydrogels, and other drug delivery systems have been extensively studied in OA therapy. This paper reviews the late research development on OA treated via IA drug delivery systems.

Self-assembled lyotropic liquid crystal gel for osteoarthritis treatment via anti-inflammation and cartilage protection

2021 ◽  
Author(s):  
Liling Mei ◽  
Hui Wang ◽  
Jintian Chen ◽  
Ziqian Zhang ◽  
Feng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liquid Crystal ◽  
Effective Treatment ◽  
Drug Delivery System ◽  
Cartilage Degeneration ◽  
Lyotropic Liquid Crystal ◽  
Joint Disease ◽  
Osteoarthritis Treatment ◽  
Anti Inflammation ◽  
And Cartilage

Osteoarthritis (OA) is a chronic joint disease with occurrence of articular inflammation and cartilage degeneration. An ideal drug delivery system for effective treatment of OA should integrate inflammation alleviation with...

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Nanotheranostic agents for neurodegenerative diseases

2020 ◽  
Vol 4 (6) ◽  
pp. 645-675
Author(s):  
Parasuraman Padmanabhan ◽  
Mathangi Palanivel ◽  
Ajay Kumar ◽  
Domokos Máthé ◽  
George K. Radda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Cell Types ◽  
Specific Cell ◽  
Ageing Population ◽  
Target Tissue ◽  
Therapeutic Approaches ◽  
Surface Receptors ◽  
Theranostic Agents ◽  
Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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