Magnesium-based layered double hydroxide nanosheets: a new bone repair material with unprecedented osteogenic differentiation performance

Nanoscale ◽  
2020 ◽  
Vol 12 (37) ◽  
pp. 19075-19082
Author(s):  
Yingjie Wang ◽  
Xuan Mei ◽  
Yanyan Bian ◽  
Tingting Hu ◽  
Xisheng Weng ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Layered Double Hydroxide ◽  
Bone Repair ◽  
Repair Material ◽  
Double Hydroxide ◽  
Bone Repair Material

Monolayer magnesium-based layered double hydroxide nanosheets loaded with alendronate were fabricated, which showed unprecedented osteogenic differentiation and bone regeneration performance.

Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials

2017 ◽  
Vol 5 (12) ◽  
pp. 2245-2253 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Zheng-liang Xu ◽  
Qin-Fei Ke ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Self Assembly ◽  
Bone Repair ◽  
Repair Materials ◽  
Double Hydroxide ◽  
First Time ◽  
Bone Repair Materials

The self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system was demonstrated for the first time to improve the cytocompatibility and enhance the osteoinductivity for the treatment of bone defects.

MgAl layered double hydroxide/chitosan porous scaffolds loaded with PFTα to promote bone regeneration

Nanoscale ◽  
2017 ◽  
Vol 9 (20) ◽  
pp. 6765-6776 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Qin-Fei Ke ◽  
You-Shui Gao ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Layered Double Hydroxide ◽  
Porous Scaffolds ◽  
Double Hydroxide

scholarly journals Human Adipose-Derived Mesenchymal Stem Cells-Incorporated Silk Fibroin as a Potential Bio-Scaffold in Guiding Bone Regeneration

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 853 ◽  
Author(s):  
Dewi Sartika ◽  
Chih-Hsin Wang ◽  
Ding-Han Wang ◽  
Juin-Hong Cherng ◽  
Shu-Jen Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Osteogenic Differentiation ◽  
Silk Fibroin ◽  
Bone Repair ◽  
Matrix Deposition ◽  
Calvarial Defects

Recently, stem cell-based bone tissue engineering (BTE) has been recognized as a preferable and clinically significant strategy for bone repair. In this study, a pure 3D silk fibroin (SF) scaffold was fabricated as a BTE material using a lyophilization method. We aimed to investigate the efficacy of the SF scaffold with and without seeded human adipose-derived mesenchymal stem cells (hASCs) in facilitating bone regeneration. The effectiveness of the SF-hASCs scaffold was evaluated based on physical characterization, biocompatibility, osteogenic differentiation in vitro, and bone regeneration in critical rat calvarial defects in vivo. The SF scaffold demonstrated superior biocompatibility and significantly promoted osteogenic differentiation of hASCs in vitro. At six and twelve weeks postimplantation, micro-CT showed no statistical difference in new bone formation amongst all groups. However, histological staining results revealed that the SF-hASCs scaffold exhibited a better bone extracellular matrix deposition in the defect regions compared to other groups. Immunohistochemical staining confirmed this result; expression of osteoblast-related genes (BMP-2, COL1a1, and OCN) with the SF-hASCs scaffold treatment was remarkably positive, indicating their ability to achieve effective bone remodeling. Thus, these findings demonstrate that SF can serve as a potential carrier for stem cells, to be used as an osteoconductive bioscaffold for BTE applications.

rBMSC osteogenic differentiation enhanced by graphene quantum dots loaded with immunomodulatory layered double hydroxide nanoparticles

2021 ◽  
Author(s):  
Zhaojie Wang ◽  
Huiyi Yang ◽  
Yuxin Bai ◽  
Liming Cheng ◽  
Rongrong Zhu
Keyword(s):  
Quantum Dots ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Layered Double Hydroxide ◽  
Therapeutic Potential ◽  
Graphene Quantum Dots ◽  
Allogeneic Bone ◽  
Alizarin Red ◽  
Alkaline Phosphatase Staining ◽  
Double Hydroxide

Abstract Bone tissue defects caused by disease, trauma, aging or genetic factors emerged as one of the main factors that endanger human health. At present, advanced development of bone tissue engineering and regenerative medicine focused on the biomaterials regulated stem cell for responsive differentiation. In vivo transplantation of allogeneic bone materials has the needs of both osteogenic and immune regulation function. In this study, we utilized the extensively proved biocompatible layered double hydroxide (LDH) nanoparticles as the nanocarrier of graphene quantum dots (GQD), the functional loading was validated by characteristics analysis of scanning electron microscopy, surface zeta potential, X-ray diffraction and fourier transform infrared spectroscopy. Further, we investigated the cellular uptake of nanoparticles in rat bone marrow derived mesenchymal stem cells, the significant enhanced endocytosis was occurred in LDH-GQD treated groups. The enhanced osteogenic differentiation abilities of LDH-GQD were systematically investigated through alkaline phosphatase staining, alizarin red staining and qPCR analysis. In addition, the anti-inflammatory regulation of LDH facilitated the phenotypic transition of macrophage in LDH-GQD nanocomposites. Overall, the successful construction and functional validation of nanomaterials in this study will provide clinical therapeutic potential in bone defects regeneration.

Copper-doped mesoporous bioactive glass endows magnesium based scaffold with antibacterial activity and corrosion resistance

2021 ◽  
Author(s):  
Youwen Yang ◽  
changfu lu ◽  
mingli yang ◽  
dongsheng wang ◽  
Shuping Peng ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Corrosion Resistance ◽  
Bacterial Infection ◽  
Bioactive Glass ◽  
Bone Repair ◽  
Repair Material ◽  
Metal Element ◽  
Biodegradable Magnesium ◽  
Bone Repair Material ◽  
Mesoporous Bioactive Glass

Biodegradable magnesium (Mg) scaffold as bone repair material is desired to own antibacterial function to reduce the risk of bacterial infection. The alloying with antibacterial metal element such as copper...

The improvement of corrosion resistance, biocompatibility and osteogenesis of the novel porous Mg–Nd–Zn alloy

2017 ◽  
Vol 5 (36) ◽  
pp. 7661-7674 ◽  
Author(s):  
Wei Liu ◽  
Jiaxing Wang ◽  
Guofeng Jiang ◽  
Jinxiao Guo ◽  
Qiuyan Li ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Bone Repair ◽  
Repair Material ◽  
The Novel ◽  
Zn Alloy ◽  
Bone Repair Material

A magnesium scaffold is a promising biodegradable bone repair material.

Development of PLGA/layered double hydroxide microsphere-sintered scaffolds for bone regeneration

2016 ◽  
Vol 32 ◽  
pp. e96 ◽  
Author(s):  
K. Khoshroo ◽  
T.S. Jafarzadeh Kashi ◽  
M. Bures ◽  
M. Tahriri ◽  
L. Tayebi
Keyword(s):  
Bone Regeneration ◽  
Layered Double Hydroxide ◽  
Double Hydroxide
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