scholarly journals Biphenyl Wrinkled Mesoporous Silica Nanoparticles for pH-Responsive Doxorubicin Drug Delivery

Materials ◽  
2020 ◽  
Vol 13 (8) ◽  
pp. 1998 ◽  
Author(s):  
Jason Lin ◽  
Chuanqi Peng ◽  
Sanjana Ravi ◽  
A. K. M. Nur Alam Siddiki ◽  
Jie Zheng ◽  
...  
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
High Surface ◽  
Average Particle Size ◽  
Average Particle ◽  
Mcf 7

Biphenyl wrinkled mesoporous silica nanoparticles with controlled particle size and high surface area were evaluated for the storage and delivery of doxorubicin. The average particle size and surface area were ~70 nm and ~1100 m2/g. The doxorubicin loading efficiency was 38.2 ± 1.5 (w/w)% and the release was pH dependent. The breast cancer cell line, MCF-7 (Michigan Cancer Foundation-7) was used for the in vitro drug release study. The cytotoxicity of doxorubicin-loaded nanoparticles was significantly higher than free doxorubicin. Fluorescence images showed biphenyl wrinkled mesoporous silica (BPWS) uptake by the MCF-7 cells. The biphenyl bridged wrinkled silica nanoparticles appear promising for hydrophobic drug loading and delivery.

scholarly journals Hyper-Crosslinked Polymer Nanocomposites Containing Mesoporous Silica Nanoparticles with Enhanced Adsorption Towards Polar Dyes

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1388
Author(s):  
Marco Guerritore ◽  
Rachele Castaldo ◽  
Brigida Silvestri ◽  
Roberto Avolio ◽  
Mariacristina Cocca ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Organic Dyes ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Reactive Dye ◽  
New Strategy ◽  
Enhanced Adsorption

The development of new styrene-based hyper-crosslinked nanocomposites (HCLN) containing mesoporous silica nanoparticles (MSN) is reported here as a new strategy to obtain functional high surface area materials with an enhanced hydrophilic character. The HCLN composition, morphology and porous structure were analyzed using a multi-technique approach. The HCLN displayed a high surface area (above 1600 m2/g) and higher microporosity than the corresponding hyper-crosslinked neat resin. The enhanced adsorption properties of the HCLN towards polar organic dyes was demonstrated through the adsorption of a reactive dye, Remazol Brilliant Blue R (RB). In particular, the HCLN containing 5phr MSN showed the highest adsorption capacity of RB.

scholarly journals DESIGN AND DEVELOPMENT OF LULICONAZOLE LOADED MESOPOROUS SILICA NANOPARTICLES AS HYDROGEL FOR MYCOTIC DISEASES

2021 ◽  
Vol 10 (4) ◽  
pp. 3148-3153
Author(s):  
Aachal Anil Gosavi
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
High Surface Area ◽  
Specific Area ◽  
Water Soluble ◽  
Drug Dissolution

The aim of the present work was to design and synthesize of mesoporous silica nanoparticles as topical hydrogel formulation for inclusion of poorly water soluble antifungal drug like Luliconazole as a drug delivery platform. The SBA-15 was prepared to evaluate its application as a carrier for Luliconazole drug delivery. Its molecular size was suitable for incorporation in to the mesoporous of the SBA-15 materials. The SBA-15 was characterized by FTIR, UV analysis, Particle size, Transmission electron microscopy. The Synthesized Mesoporous silica i.e. SBA-15 was of mean particle size of 15 nm and specific area 283.763m2/g respectively. The results revealed that prepared mesoporous silica have small particle size, high surface area, and enhanced drug dissolution rate. The results obtained showed that Luliconazole was loaded with great efficiency into the SBA-15 which leads to enhanced diffusion of drug. Luliconazole hydrogel formulations improved medication permeation across the skin appropriate polymer was used to produce the formulation (Carbopol 934p and HPMC). The physiochemical parameters of all the established luliconazole formulations were assessed, including gel appearance, pH, viscosity, spreadability, globule size, Zeta potential, and drug content. Many of the above parameters yielded positive outcomes but F1 and F3 batch results was were unacceptable ranges. It can be assumed that the formulation F1 and F3 resulted in improved spreadability, stability, and homogeneity, as well as a stronger drug release analysis.

scholarly journals HOLLOW MESOPOROUS SILICA NANOPARTICLES FABRICATION FOR ANTICANCER DRUG DELIVERY

2020 ◽  
Vol 58 (1) ◽  
pp. 39 ◽  
Author(s):  
Ngoc Tram Nguyen Thi ◽  
Dai Hai Nguyen
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Agents ◽  
Pore Volume ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
High Surface ◽  
Loading Capacity ◽  
Hollow Mesoporous Silica

Mesoporous silica nanoparticles (MSNs) have attracted significant attention from researchers thanks to their high surface area and pore volume, which can increase drug loading capacity. Moreover, MSNs, with their biocompatibility and ease of surface functionalization, are seen as potential drug delivery system. However, the loading of drug into MSNs system still needs further improvement. In this study, hollow mesoporous silica nanoparticles (HMSNs) were fabricated in order to increase the drug loading capacity of nanosilica materials. The synthesized HMSNs possessed inner hollow cores that could remarkably raise the total pore volume and thus improve the capacity for cargo loading. HMSNs were synthesized according to the hard-template method with three main steps: (1) forming of solid SiO2 nanoparticles as templates, (2) forming of core-shell structure by coating MSN layers onto the templates, and (3) forming of hollow core structure by etching away the solid template. The HMSNs product was characterized by TEM, XRD, TGA and FTIR. In addition, drug loading capacity of the material was evaluated with doxorubicin as model drug. The results indicated remarkable improvement in drug loading capacity, compared to MSN sample. Cell assays on cancer lines showed high biocompatibility. These results demonstrated the potential of HMSNs in the delivery of anticancer agents.

scholarly journals Optimization of Synthesis Parameters of Mesoporous Silica Nanoparticles Based on Ionic Liquid by Experimental Design and Its Application as a Drug Delivery Agent

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Eleen Dayana Mohamed Isa ◽  
Haslina Ahmad ◽  
Mohd Basyaruddin Abdul Rahman
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Optimization Method ◽  
Main Effects ◽  
Quadratic Models

Optimization is a process utilized to discover the best condition to generate the best possible outcome. One of the common optimization method used in the field of chemistry is response surface methodology (RSM). This method consists of mathematical and statistical techniques which relate the responses with the variables of interest. There are many experimental designs in RSM, and one of the most common one is the Box-Behnken design (BBD). In this work, BBD was employed to analyze the main effects and interactions of the reaction temperature, amount of template, and amount of triethanolamine (TEA) on the two responses which are the surface area (SA) and particle size (PS) of ionic liquid templated mesoporous silica nanoparticles (MSNs). It was found that the SA and PS were fitted with linear and quadratic models, respectively. MSNs with the highest surface area (999.051 m2 g-1) was chosen for the application of drug delivery; thus, drug loading and drug release experiments were conducted. From these studies, it was found that 37% of drug (quercetin) was successfully encapsulated in MSN and, in 48 hours, 32% of the drug was released.

Mesoporous Silica Nanoparticles with Controllable Pore Size: Preparation and Drug Release

2013 ◽  
Vol 774-776 ◽  
pp. 536-539
Author(s):  
Yang Wang ◽  
Yan Shan ◽  
Ke Zheng Chen ◽  
Lian Gao
Keyword(s):  
Electron Microscopy ◽  
Particle Size ◽  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
High Specific Surface Area ◽  
Transmission Electron ◽  
Uniform Particle Size

Mesoporous silica nanoparticles (MSNs), with controllable pore size at wider range (2-13 nm) and particle size about 100 nm, have been successfully prepared using different templates. N2 adsorptiondesorption isotherms, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to characterize the material. The results showed that the MSNs have high specific surface area, controllable pore-size and the pore volume, and uniform particle size. Their drug delivery properties were investigated. It was found that the amount of loading DOX is increased with surface area, and the multi-release experiments showed that they had a sustained-release property; MSNs with larger pore size had the larger amount of DOX.

scholarly journals High surface area nano-sized La0.6Ca0.4MnO3 perovskite powder prepared by low temperature pyrolysis of a modified citrate gel

2009 ◽  
Vol 7 (4) ◽  
pp. 809-817 ◽  
Author(s):  
Meysam Soleymani ◽  
Ahmad Moheb ◽  
Ezatolah Joudaki
Keyword(s):  
Particle Size ◽  
Surface Area ◽  
Single Phase ◽  
High Surface ◽  
Average Particle Size ◽  
High Surface Area ◽  
Average Particle ◽  
Precursor Method ◽  
Modified Method ◽  
Low Temperature Pyrolysis

AbstractSingle phase nanocrystalline La0.6Ca0.4MnO3 powder was synthesized by both the usual and a modified citrate gel precursor method, and the effects on the formation of homogeneous nano-sized powder with a perovskite structure were investigated. In the modified method, single phase La0.6Ca0.4MnO3 powder with an average particle size of 17.2 nm was obtained when the powder was pyrolyzed at 520°C for 2 h. Its specific surface area was 40.7 m2 g−1, about 4-fold larger than that of powder made by the usual citrate gel method.

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

2020 ◽  
Vol 27 (22) ◽  
pp. 3623-3656 ◽  
Author(s):  
Bruno Fonseca-Santos ◽  
Patrícia Bento Silva ◽  
Roberta Balansin Rigon ◽  
Mariana Rillo Sato ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Delivery Systems ◽  
Average Particle ◽  
Minor Importance ◽  
Routes Of Administration ◽  
Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Mesoporous Silica Nanoparticles of Hydroxyurea: Potential

2020 ◽  
Vol 10 ◽  
Author(s):  
Kumar Nishchaya ◽  
Swatantra K.S. Kushwaha ◽  
Awani Kumar Rai
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Average Particle Size ◽  
Silica Nanoparticle ◽  
Average Particle ◽  
Independent Variables ◽  
Lower Temperature

Background: Present malignant cancer medicines has the advancement of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer medication in malignant growth tissue. Aim: In the present investigation, a silica nanoparticles (MSNs) stacked with hydroxyurea were combined and was optimized for dependent and independent variables. Method: In this study, microporous silica nanoparticle stacked with neoplastic medication had been prepared through emulsification followed with solvent evaporation method. Prepared MSNs were optimized for dependent and independent variables. Different formulations were prepared with varying ratio of polymer, lipid and surfactant which affects drug release and kinetics of drug release pattern. The obtained MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release kinetics study, stability testing in order to investigate the nanoparticle characteristics. Results: The percentage drug entrapment of the drug for the formulations F1, F2, F3, was found to be 27.78%, 65.52% and 48.26%. The average particle size for F2 formulation was found to be 520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3 was found to be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled drug delivery for 6 hours. Conclusion: From the stability studies data it can be culminated that formulations are most stable when stored at lower temperature or in refrigerator i.e. 5˚C ± 3˚C. It can be concluded that MSN’s loaded with hydroxyurea is a promising approach towards the management of cancer due to its sustained release and less side effects.

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