scholarly journals Self-assembly of four generations of RNA dendrimers for drug shielding with controllable layer-by-layer release

Nanoscale ◽  
2020 ◽  
Vol 12 (31) ◽  
pp. 16514-16525
Author(s):  
Xin Li ◽  
Mario Vieweger ◽  
Peixuan Guo
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Shielding Effect ◽  
Layer By Layer ◽  
Novel Drug ◽  
Stepwise Dissociation ◽  
Controllable Layer

Multifunctional RNA dendrimers have been developed as novel drug delivery platforms, which show shielding effect of loaded cargos and temperature triggered stepwise dissociation.

scholarly journals Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Pin Chen ◽  
Xin Wang ◽  
Yan Dong ◽  
Xiaohong Hu
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Ph Value ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ocular Drug Delivery ◽  
Layer By Layer ◽  
Uv Spectrum ◽  
Modification Technique ◽  
Assembly Procedure

Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work. Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, sinceβ-CD showed good drug delivery property. The properties such as the contact angle and transparency varied a little with the deposition of poly(CM-β-CD)/PLL multilayer. Orfloxacin and puerarin were loaded into multilayer during the self-assembly procedure by two methods, which were tracked by the largest drug absorbance of UV spectrum. The loaded drug amount by incorporating drugs into poly(CM-β-CD) solution was larger than that by incorporating drugs into PLL solution. The loaded drug in the multilayer could gradually be released from multilayer in some period either for orfloxacin or for puerarin. The drug release behavior was influenced by drug loading method and pH value of released medium. Moreover, the balanced released drug amount by incorporating drugs into poly(CM-β-CD) solution is much smaller than that by incorporating drugs into PLL solution.

Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin

2020 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Yihong He ◽  
Cong Wu ◽  
Jiayu Duan ◽  
Junming Miao ◽  
Hongyu Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeting Therapy ◽  
Tumor Bearing ◽  
Clinical Benefits ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.

Dual Drug Delivery Microcapsules via Layer-by-Layer Self-Assembly

Langmuir ◽  
2009 ◽  
Vol 25 (18) ◽  
pp. 10515-10522 ◽  
Author(s):  
Uttam Manna ◽  
Satish Patil
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Layer By Layer ◽  
Dual Drug

Effect of the synthesis method on the performance of Fe3O4–inositol hexaphosphate as a drug delivery vehicle for combination therapeutics with doxorubicin

2017 ◽  
Vol 41 (13) ◽  
pp. 5305-5312 ◽  
Author(s):  
Dandan Xu ◽  
Tongying Xu ◽  
Xuejie Guo ◽  
Qi Liu ◽  
Jingyuan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Solvothermal Synthesis ◽  
Synthesis Method ◽  
Precipitation Method ◽  
Layer By Layer ◽  
Delivery Vehicle ◽  
Inositol Hexaphosphate ◽  
One Step ◽  
Co Precipitation

Fe3O4–IP6 was fabricated via layer-by-layer electrostatic self-assembly following a solvothermal synthesis method and via a one-step co-precipitation method.

scholarly journals Layer-by-Layer Biomaterials for Drug Delivery

2020 ◽  
Vol 22 (1) ◽  
pp. 1-24 ◽  
Author(s):  
Dahlia Alkekhia ◽  
Paula T. Hammond ◽  
Anita Shukla
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Self Assembly ◽  
Controlled Drug Release ◽  
In Vivo Studies ◽  
Layer By Layer ◽  
Microbial Infection ◽  
Multiple Substrates

Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic agents; coat multiple substrates of all scales (e.g., nanoparticles to implants); and exhibit tuned, targeted, and/or responsive drug release behavior. The functional behavior of LbL films can be related to their physicochemical properties. In this review, we highlight recent advances in the development of LbL-engineered biomaterials for drug delivery, demonstrating their potential in the fields of cancer therapy, microbial infection prevention and treatment, and directing cellular responses. We discuss the various advantages of LbL biomaterial design for a given application as demonstrated through in vitro and in vivo studies.

Layer-by-layer self-assembly films for buccal drug delivery: The effect of polymer cross-linking

2020 ◽  
Vol 59 ◽  
pp. 101897
Author(s):  
Bissera Pilicheva ◽  
Yordanka Uzunova ◽  
Ivan Bodurov ◽  
Asya Viraneva ◽  
Ginka Exner ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Cross Linking ◽  
Layer By Layer ◽  
Buccal Drug Delivery

Preparation of graphene oxide–chitosan nanocapsules and their applications as carriers for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104522-104528 ◽  
Author(s):  
Yanbao Li ◽  
Lei Jiang
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Self Assembly ◽  
Layer By Layer ◽  
Assembly Method

The stable graphene oxide–chitosan nanocapsules as carriers for drug delivery were prepared via layer-by-layer self-assembly method.

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