Effect of the synthesis method on the performance of Fe3O4–inositol hexaphosphate as a drug delivery vehicle for combination therapeutics with doxorubicin

2017 ◽  
Vol 41 (13) ◽  
pp. 5305-5312 ◽  
Author(s):  
Dandan Xu ◽  
Tongying Xu ◽  
Xuejie Guo ◽  
Qi Liu ◽  
Jingyuan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Solvothermal Synthesis ◽  
Synthesis Method ◽  
Precipitation Method ◽  
Layer By Layer ◽  
Delivery Vehicle ◽  
Inositol Hexaphosphate ◽  
One Step ◽  
Co Precipitation

Fe3O4–IP6 was fabricated via layer-by-layer electrostatic self-assembly following a solvothermal synthesis method and via a one-step co-precipitation method.

Effect of the Synthesis Method on the Properties of Ultrafine YAG Powder

2018 ◽  
Vol 281 ◽  
pp. 40-45
Author(s):  
Jie Guang Song ◽  
Lin Chen ◽  
Cai Liang Pang ◽  
Jia Zhang ◽  
Xian Zhong Wang ◽  
...  
Keyword(s):  
Particle Size ◽  
Calcination Temperature ◽  
Hydrothermal Reaction ◽  
Synthesis Method ◽  
Particle Morphology ◽  
Precipitation Method ◽  
Molar Ratio ◽  
Synthesis Process ◽  
Powder Materials ◽  
Co Precipitation

YAG materials has a number of unique properties, the application is very extensive. In this paper, the superfine YAG powder materials were prepared by co-precipitation method and hydrothermal precipitation method. The influence of synthesis process on the morphology of the powder was investigated. The results showed that the precursor powder prepared via the co-precipitation method is mainly from amorphous to crystalline transition with the increasing calcination temperature, the precursor agglomeration is more serious, In the process of increasing the calcination temperature, the dispersibility of the roasted powder is greatly improved, which is favorable for the growth of the crystal grains, so that the particle size of the powder is gradually increased, the YAG precursor prepared by the co-precipitation method is transformed into YAG crystals, the phase transition occurs mainly between 900 and 1100°C. When the molar ratio of salt to alkali is Y3+: OH-=1: 8 via the hydrothermal reaction, the YAG particles with homogeneous morphology can be obtained. When the molar ratio of salt and alkali is increased continuously, the morphology of YAG particles is not obviously changed. The co-precipitation method is easy to control the particle size, the hydrothermal method is easy to control the particle morphology.

scholarly journals Self-Assembly Mechanism of a Peptide-Based Drug Delivery Vehicle

ACS Omega ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 3143-3155 ◽  
Author(s):  
Gopal Pandit ◽  
Karabi Roy ◽  
Umang Agarwal ◽  
Sunanda Chatterjee
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Assembly Mechanism

Sonochemical Co-Precipitation Synthesis of Gallic Acid-Modified Magnetite

2015 ◽  
Vol 1101 ◽  
pp. 286-289 ◽  
Author(s):  
Maya Rahmayanti ◽  
Sri Juari Santosa ◽  
Sutarno
Keyword(s):  
Magnetic Properties ◽  
Gallic Acid ◽  
Precipitation Method ◽  
Vibrating Sample Magnetometer ◽  
X Ray Diffraction ◽  
X Ray ◽  
One Step ◽  
The Fourier Transform ◽  
The One ◽  
Co Precipitation

Gallic acid-modified magnetites were synthesized by one and two-step reactions via the newly developed sonochemical co-precipitation method. The two-step reaction included the formation of magnetite powder and mixing the magnetite powder with gallic acid solution, while the one-step reaction did not go through the formation magnetite powder. The obtained gallic acid-modified magnetites were characterized by the Fourier Transform Infrared (FTIR) spectroscopy, the X-Ray Diffraction (XRD) and the Scanning Electron Microscopy (SEM). More over, the magnetic properties were studied by using a Vibrating Sample Magnetometer (VSM). The characterization results showed that there were differences in crystalinity, surface morphology and magnetic properties of products that were formed by one and two-step reactions.

Ordered mesoporous silica/polyvinylidene fluoride composite membranes for effective removal of water contaminants

2016 ◽  
Vol 4 (10) ◽  
pp. 3850-3857 ◽  
Author(s):  
Jianwei Fan ◽  
Dandan Li ◽  
Wei Teng ◽  
Jianping Yang ◽  
Yong Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Polyvinylidene Fluoride ◽  
Composite Membranes ◽  
Precipitation Method ◽  
Ordered Mesoporous Silica ◽  
Water Contaminants ◽  
Effective Removal ◽  
Ordered Mesoporous ◽  
One Step ◽  
Co Precipitation

Ordered mesoporous silica/polyvinylidene fluoride membranes were fabricated via a versatile and industrially compatible one-step immersion co-precipitation method. They exhibit effective decontamination performance for water containing methylene blue and Cu(ii) ions, respectively.

Synthesis and Self-Assembly of a Peptide - Amphiphile as a Drug Delivery Vehicle

2013 ◽  
Vol 66 (1) ◽  
pp. 23 ◽  
Author(s):  
Soo Jung Son ◽  
Margaret A. Brimble ◽  
Sunghyun Yang ◽  
Paul W. R. Harris ◽  
Tom Reddingius ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Long Range ◽  
Self Assembly ◽  
The Self ◽  
Long Range Order ◽  
Delivery Vehicle ◽  
Peptide Amphiphile ◽  
Drug Delivery Vehicle ◽  
Hydrophobic Moiety

The formation of functional liposomes by the self assembly of a peptide–amphiphile that comprises the neuroprotective tripeptide motif glycyl-prolyl-glutamic acid linked to a hydrophobic moiety is reported. The self-assembled peptide–lipid conjugate displays long range order and can be dispersed as nanometre sized particles.

scholarly journals Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Pin Chen ◽  
Xin Wang ◽  
Yan Dong ◽  
Xiaohong Hu
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Ph Value ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ocular Drug Delivery ◽  
Layer By Layer ◽  
Uv Spectrum ◽  
Modification Technique ◽  
Assembly Procedure

Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work. Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, sinceβ-CD showed good drug delivery property. The properties such as the contact angle and transparency varied a little with the deposition of poly(CM-β-CD)/PLL multilayer. Orfloxacin and puerarin were loaded into multilayer during the self-assembly procedure by two methods, which were tracked by the largest drug absorbance of UV spectrum. The loaded drug amount by incorporating drugs into poly(CM-β-CD) solution was larger than that by incorporating drugs into PLL solution. The loaded drug in the multilayer could gradually be released from multilayer in some period either for orfloxacin or for puerarin. The drug release behavior was influenced by drug loading method and pH value of released medium. Moreover, the balanced released drug amount by incorporating drugs into poly(CM-β-CD) solution is much smaller than that by incorporating drugs into PLL solution.

scholarly journals Synthesis and Characterization of TiO2 Nanoparticles for Solar Cell Applications

2019 ◽  
Vol 8 (9) ◽  
pp. 2462-2465
Keyword(s):  
Solar Cell ◽  
Tio2 Nanoparticles ◽  
Sol Gel ◽  
Synthesis Method ◽  
Pollutant Removal ◽  
Precipitation Method ◽  
Micro Particles ◽  
Wide Range ◽  
Titanium Tetra Isopropoxide ◽  
Co Precipitation

Titanium dioxide (TiO2 ) nanoparticles were synthesized using three different approaches successfully. These approaches were adopted as per different applications of TiO2 nanoparticles. These samples were characterized using X- ray diffraction (XRD) technique. XRD revealed nanocrystalline regime of TiO2 nanoparticles in each approach. The calculated size of nanoparticle was less than 11 nm in the used chemical approaches. Prominent and broad peaks were observed in XRD pattern for all samples, which showed all samples were in nanocrytalline form. The particle size was calculated for first three most intense prominent XRD peaks. By adopting sol gel method using Titanium tetra isopropoxide (TTIP) as precursor, the synthesized Titania particles were pure anatas and of size 7 to 11nm and using co-precipitation method using TiCl3 as precursor synthesized Titania were pure rutile and of size 3 to 7 nm. The co-precipitation method has been best suited for getting smaller nanoparticles. It was also observed that Solid state mechanical reduction root can be used to reduce the size of Titania micro-particles up to about 60 nm but phase of nanoparticles remains same as starting microparticles. It has been seen that the material properties of TiO2 can be tuned by proper method of synthesis. The work may play important role to choose particular synthesis method for specific application. These nano synthesized TiO2 materials may be used in a wide range of applications such as dye sensitized solar cell, photocatalysis, antibacterial, environment pollutant removal and photoactivated self cleaning properties etc

Synthesis and Characterization of Mesoporous Hydroxyapatite

2010 ◽  
Vol 63 ◽  
pp. 152-157 ◽  
Author(s):  
Kien Seng Lew ◽  
Radzali Othman ◽  
Fei Yee Yeoh
Keyword(s):  
Self Assembly ◽  
Bone Cells ◽  
Hexagonal Phase ◽  
The Body ◽  
Precipitation Method ◽  
Hexadecyltrimethylammonium Bromide ◽  
Phosphate Solution ◽  
Decyltrimethylammonium Bromide ◽  
Constant Ph ◽  
Co Precipitation

Among the porous media, hydroxyapatite (HA) possesses good biocompatibility and bioactivity properties with respect to bone cells and tissues, due to its similarity with the hard tissues of the body. In this study, mesoporous HA was synthesized using a soft-templating technique via a self-assembly between HA and cationic surfactant decyltrimethylammonium bromide (C10TAB), which is analogous to the synthesis of mesoporous silica MCM-41. This co-precipitation method involved formation of hexagonal-phase micelle template by the surfactant and the precipitation of HA surrounding the micelle. After ageing, calcination was carried out to remove the templates, revealing the pores as well as to produce more crystalline and more stable HA structure. This study showed that instead of hexadecyltrimethylammonium bromide (C16TAB) which was conventionally used, C10TAB could also be used to synthesize single-phase mesoporous HA with pore size ca. 3 nm. Ageing temperature of 120 °C, for 24 hours was found sufficient for the formation of mesoporous HA. The adsorption properties of mesoporous HA was able to be improved by increasing the water content of C10TAB-phosphate solution and by constant pH adjustment during the mixing of solutions.

Fabrication and Characterization of Polysorbate/Ironmolybdophosphate Nanocomposite: Ion Exchange Properties and pH-responsive Drug Carrier System for Methylcobalamin

2020 ◽  
Vol 16 (2) ◽  
pp. 138-148
Author(s):  
Gaurav Sharma ◽  
Amit Kumar ◽  
Inamuddin ◽  
Mansi Sood ◽  
Abdullah M. Asiri
Keyword(s):  
Drug Delivery ◽  
Fourier Transform ◽  
Ion Exchange ◽  
Drug Release ◽  
Sodium Nitrate ◽  
Fourier Transform Infrared ◽  
Exchange Capacity ◽  
Precipitation Method ◽  
Ion Exchange Capacity ◽  
Co Precipitation

Background: Nanocomposites are of great interest due to their competency to show multifunctional properties. They have been recently given much attention due to their credibility to offer the synergistic feature of organic material with those of inorganic constituents. Different types of nanocomposites have been prepared to date and are being used for different applications. The delivery of drugs in the human body at a particular site was one of the major problems in the medicinal field. The nanocomposite formulations can be used to provide controlled release and they can be combined with ligands for targeted drug delivery. Applications of the nanocomposites as ion exchangers are also increasing at a faster rate. Due to this, they help in the softening of the water. They can also be easily recharged by washing them with a solution containing a high concentration of sodium ions. In the present paper, we have worked on the synthesis and applications of the polysorbate/ironmolybdophosphate (PS/FMP) nanocomposite. Methods: Polysorbate/ironmolybdophosphate (PS/FMPS) was synthesized by co-precipitation method in the presence of polysorbate. The material was well characterized using X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy, (FTIR) scanning transmission microscopy (SEM), and transmission electron microscopy (TEM). Physicochemical properties of material were studied in detail. Drug delivery behavior of polysorbate/ironmolybdophosphate was investigated by using methylcobalamin as a test drug. Results: The polysorbate/ironmolybdophosphate nanocomposite show enhanced Na+ ion exchange capacity of 2.1 meq/g. It has been revealed that PS/FMP nanocomposite was thermally stable as it retained the ion exchange capacity of 40.4 % at 400°C. An optimum concentration of sodium nitrate (eluent) was found to be 1.0 M for the complete removal of H+ ions from the PS/FMP column. The optimum volume of sodium nitrate (eluent) was found to be 230 mL. The FTIR spectra showed the changes in intensities of characteristic peaks in PS/FMP and in drug loaded on PS/FMP nanocomposite. The characteristic peak at 1043-1061 cm-1 was observed for ionic phosphate stretching, 560-567 cm-1 for iron group and 959 cm-1 due to molybdate present in the material. The additional peak at 3390 cm-1 and 1711 cm-1 were due to -OH and C=O stretching due to the presence of these groups in the structure of polysorbate. The peak present at 430 cm-1 might be due to the presence of Co-O stretching of methylcobalamin. The XRD results confirmed the semicrystalline structure of FMP and PS/FMP. Scanning electron micrographs results revealed the beaded surface of FMP changes to fibrous surface in case of PS/FMP nanocomposite. The TEM images indicate the appearance of smooth surfactant layer on the surface of FMP. The size of the nanocomposite is between 10- 70 nm. The drug loading efficiency and encapsulation efficiency were found to be 35.2%. and 60.4%, respectively. The cumulative drug release of methylcobalamin was studied for the PS/FMP nanocomposite. The order of drug release was found to be pH 9.4 (54.6%) > pH 7.4 (46.4%) > saline (pH 5.7) (36.2%) > pH 2.2 (33.9%). The release at pH 9.4 was higher. As the pH of medium changes from acidic to basic i.e. 2.2 - 9.4, there is an appreciable increase in drug release from the PS/FMP nanocomposite due to the presence of more OH- ions resulting in neutralization of cationic nanocomposite and thus increasing the rate of drug release by ion exchange process and matrix deterioration. : The novel nanocomposite PS/FMP has been synthesized by a simple co-precipitation method. The increase in Na+ ion exchange capacity for nanocomposite is due to the binding of organic part (Polysorbate) with inorganic ironmolybdophosphate. The physiochemical properties of PS/FMP were found to be superior. Fourier transform infrared spectra of PS/FMP and drug loaded PS/FMP confirmed the formation of materials. The SEM results indicated the surface of synthesized FMP is bead-like appearance whereas the beaded surface of FMP changes to fibrous surface on the addition of polysorbate thus indicated the fabrication of nanocomposite. The cumulative drug release of methylcobalamin was studied and the order of drug release was found to be pH 9.4 > pH 7.4 > saline (pH 5.7) > pH 2.2. Thus PS/FMP is a promising multifunctional nanocomposite.

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