scholarly journals Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging

Small ◽  
2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Yu Cheng ◽  
Qing Dai ◽  
Ramin A. Morshed ◽  
Xiaobing Fan ◽  
Michelle L. Wegscheid ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Malignant Glioma ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Efficient Delivery ◽  
Delivery Platform

scholarly journals Oncolytic Viruses for Malignant Glioma: On the Verge of Success?

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1294
Author(s):  
Yogesh R. Suryawanshi ◽  
Autumn J. Schulze
Keyword(s):  
Immune Responses ◽  
Malignant Glioma ◽  
Blood Brain Barrier ◽  
Tumor Heterogeneity ◽  
Checkpoint Inhibitors ◽  
Oncolytic Viruses ◽  
Brain Barrier ◽  
Current Status ◽  
Blood Brain ◽  
Federal Authority

Glioblastoma is one of the most difficult tumor types to treat with conventional therapy options like tumor debulking and chemo- and radiotherapy. Immunotherapeutic agents like oncolytic viruses, immune checkpoint inhibitors, and chimeric antigen receptor T cells have revolutionized cancer therapy, but their success in glioblastoma remains limited and further optimization of immunotherapies is needed. Several oncolytic viruses have demonstrated the ability to infect tumors and trigger anti-tumor immune responses in malignant glioma patients. Leading the pack, oncolytic herpesvirus, first in its class, awaits an approval for treating malignant glioma from MHLW, the federal authority of Japan. Nevertheless, some major hurdles like the blood–brain barrier, the immunosuppressive tumor microenvironment, and tumor heterogeneity can engender suboptimal efficacy in malignant glioma. In this review, we discuss the current status of malignant glioma therapies with a focus on oncolytic viruses in clinical trials. Furthermore, we discuss the obstacles faced by oncolytic viruses in malignant glioma patients and strategies that are being used to overcome these limitations to (1) optimize delivery of oncolytic viruses beyond the blood–brain barrier; (2) trigger inflammatory immune responses in and around tumors; and (3) use multimodal therapies in combination to tackle tumor heterogeneity, with an end goal of optimizing the therapeutic outcome of oncolytic virotherapy.

scholarly journals Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood–brain barrier model

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu-Li Lo ◽  
Hua-Ching Lin ◽  
Shu-Ting Hong ◽  
Chih-Hsien Chang ◽  
Chen-Shen Wang ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Tight Junction ◽  
Blood Brain Barrier ◽  
Polymeric Nanoparticles ◽  
Growth Factor Receptor ◽  
Brain Barrier ◽  
Polymeric Nanoparticle ◽  
Blood Brain ◽  
Blood Brain Barrier Model ◽  
Delivery Platform

Abstract Background Brain metastases from non-small cell lung cancer (NSCLC) remain one of the most challenging malignancies. Afatinib (Afa) is an orally administered irreversible ErbB family blocker approved for epidermal growth factor receptor (EGFR)-mutated NSCLC. However, the incidence of brain metastases in patients with NSCLC and EGFR mutation is high. One of the major obstacles in the treatment of brain metastases is to transport drugs across the blood–brain barrier (BBB). A lipid polymeric nanoparticle (LPN) modified with a tight junction-modulating peptide is a potential formulation to deliver therapeutics across the BBB. FD7 and CCD are short peptides that perturb the tight junctions (TJs) of the BBB. In this study, the use of LPN modified with FD7 or CCD as a delivery platform was explored to enhance Afa delivery across the BBB model of mouse brain-derived endothelial bEnd.3 cells. Results Our findings revealed that Afa/LPN-FD7 and Afa/LPN-CCD exhibited a homogeneous shape, a uniform nano-scaled particle size, and a sustained-release profile. FD7, CCD, Afa/LPN-FD7, and Afa/LPN-CCD did not cause a significant cytotoxic effect on bEnd.3 cells. Afa/LPN-FD7 and Afa/LPN-CCD across the bEnd.3 cells enhanced the cytotoxicity of Afa on human lung adenocarcinoma PC9 cells. FD7 and CCD-modulated TJ proteins, such as claudin 5 and ZO-1, reduced transendothelial electrical resistance, and increased the permeability of paracellular markers across the bEnd.3 cells. Afa/LPN-FD7 and Afa/LPN-CCD were also partially transported through clathrin- and caveolae-mediated transcytosis, revealing the effective activation of paracellular and transcellular pathways to facilitate Afa delivery across the BBB and cytotoxicity of Afa on PC9 cells. Conclusion TJ-modulating peptide-modified LPN could be a prospective platform for the delivery of chemotherapeutics across the BBB to the brain for the potential treatment of the BM of NSCLC.

Pediatric glioblastoma target-specific efficient delivery of gemcitabine across the blood–brain barrier via carbon nitride dots

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7927-7938 ◽  
Author(s):  
Piumi Y. Liyanage ◽  
Yiqun Zhou ◽  
Abdulrahman O. Al-Youbi ◽  
Abdulaziz S. Bashammakh ◽  
Mohammad S. El-Shahawi ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Carbon Nitride ◽  
Drug Efficacy ◽  
Effective Drug ◽  
Brain Barrier ◽  
Drug Conjugation ◽  
Blood Brain ◽  
Efficient Delivery ◽  
Pediatric Glioblastoma ◽  
Selective Target

A carbon nitride dot nanocarrier system with effective drug conjugation and selective target delivering to achieve enhanced drug efficacy on pediatric glioblastomas, while proving capability to penetrate blood–brain barrier.

Grabody B, a Novel IGF-1 Receptor-Based Shuttle, Mediates Efficient Delivery of Biologics Across the Blood-Brain Barrier

2020 ◽  
Author(s):  
Jung-Won Shin ◽  
Sungwon An ◽  
Dongin Kim ◽  
Jinhyung Ahn ◽  
Jaehyun Eom ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Efficient Delivery

scholarly journals Trafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood–Brain Barrier

2015 ◽  
Vol 12 (11) ◽  
pp. 4137-4145 ◽  
Author(s):  
Itsaso Cabezón ◽  
Gemma Manich ◽  
Raquel Martín-Venegas ◽  
Antoni Camins ◽  
Carme Pelegrí ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Blood Brain Barrier ◽  
Transferrin Receptor ◽  
Brain Barrier ◽  
Mouse Blood ◽  
Receptor Antibody ◽  
Blood Brain

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood–Brain Barrier

2018 ◽  
Vol 29 (5) ◽  
pp. 1677-1689 ◽  
Author(s):  
Carlos Fernandes ◽  
Miguel Pinto ◽  
Cláudia Martins ◽  
Maria João Gomes ◽  
Bruno Sarmento ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Dietary Antioxidants ◽  
Blood Brain ◽  
Efficient Delivery

scholarly journals Spontaneous penetration of gold nanoparticles through the blood brain barrier (BBB)

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Hagit Sela ◽  
Hagit Cohen ◽  
Paz Elia ◽  
Raya Zach ◽  
Zeev Karpas ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain
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