Ru-Tethered (R,R)-TsDPEN with DMAB as an efficient catalytic system for high enantioselective one-pot synthesis of chiral β-aminol via asymmetric transfer hydrogenation

2021 ◽  
Vol 45 (12) ◽  
pp. 5357-5362
Author(s):  
Ashish A. Mishra ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Catalytic System ◽  
Optically Active ◽  
Transfer Hydrogenation ◽  
Selective Synthesis ◽  
Asymmetric Transfer Hydrogenation ◽  
One Pot ◽  
Chiral Catalyst ◽  
One Pot Synthesis ◽  
Dimethylamine Borane

This work reflects Ru-tethered-TsDPEN as an active chiral catalyst for one pot selective synthesis of optically active α-substituted alcohols and its derivatives from α-bromo ketones in the presence of dimethylamine borane (DMAB) as the hydrogen source.

scholarly journals Preparation of Mesoporous Silica-Supported Chiral Amino Alcohols for the Enantioselective Addition of Diethylzinc to Aldehyde and Asymmetric Transfer Hydrogenation to Ketones

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Shaheen M. Sarkar ◽  
Md. Eaqub Ali ◽  
Md. Lutfor Rahman ◽  
Mashitah Mohd Yusoff
Keyword(s):  
Mesoporous Silica ◽  
Amino Alcohols ◽  
Optically Active ◽  
Transfer Hydrogenation ◽  
Catalytic Process ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Catalyst ◽  
Aromatic Alcohols ◽  
Enantioselective Addition ◽  
Cubic Mesoporous

Optically active (−)-ephedrine, (−)-norephedrine, and (−)-prolinol were immobilized onto cubic mesoporous MCM-48 silica. The immobilized amino alcohols served as a heterogeneous chiral catalyst for the asymmetric addition of diethylzinc to aldehydes and transfer hydrogenation to ketones. The developed catalytic process yielded optically enriches secondary aromatic alcohols with 92–99% conversion and 70–82% enantioselectivity.

One-pot synthesis of optically pure β-hydroxy sulfones via a heterogeneous ruthenium/diamine-promoted nucleophilic substitution-asymmetric transfer hydrogenation tandem process

2017 ◽  
Vol 7 (19) ◽  
pp. 4444-4450 ◽  
Author(s):  
Jinyu Wang ◽  
Liang Wu ◽  
Xiaoying Hu ◽  
Rui Liu ◽  
Ronghua Jin ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Nucleophilic Substitution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Functionalized Mesoporous Silica ◽  
Tandem Process ◽  
The One ◽  
Optically Pure

Chiral ruthenium/diamine-functionalized mesoporous silica is synthesized and its application in the one-pot synthesis of chiral β-hydroxy sulfones is investigated.

scholarly journals Highly Enantioselective One-Pot Synthesis of Chiral β-Heterosubstituted Alcohols via Ruthenium–Prolinamide-Catalyzed Asymmetric Transfer Hydrogenation

ACS Omega ◽  
2018 ◽  
Vol 3 (10) ◽  
pp. 12737-12745 ◽  
Author(s):  
Vijyesh K. Vyas ◽  
Prasenjit Srivastava ◽  
Prachi Bhatt ◽  
Vaishali Shende ◽  
Pushpito Ghosh ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
One Pot ◽  
One Pot Synthesis

Highly Enantioselective One-Pot Synthesis of Chiral β-Hydroxy Sulfones via Asymmetric Transfer Hydrogenation in an Aqueous Medium

2014 ◽  
Vol 16 (21) ◽  
pp. 5764-5767 ◽  
Author(s):  
Dacheng Zhang ◽  
Tanyu Cheng ◽  
Qiankun Zhao ◽  
Jianyou Xu ◽  
Guohua Liu
Keyword(s):  
Aqueous Medium ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
One Pot ◽  
One Pot Synthesis
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