Synthesis of 2′-(1,2,3-triazoyl)-acetophenones: molecular docking and inhibition of in vitro monoamine oxidase activity

2021 ◽  
Author(s):  
Gabriel P. Costa ◽  
Ítalo F. C. Dias ◽  
Mariana G. Fronza ◽  
Evelyn M. Besckow ◽  
Jenifer Fetter ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Mao Activity

The synthesis of 2′-(1,2,3-triazoyl)-acetophenones by a CuAAC using thiourea as a ligand, molecular docking and MAO activity analyses were performed.

In vitro and in vivo effect of organophosphate pesticides on monoamine oxidase activity in rat brain

1987 ◽  
Vol 7 (10) ◽  
pp. 801-803 ◽  
Author(s):  
Maitreyi Nag ◽  
Namita Nandi
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Oxidase Activity ◽  
Brain Mitochondria ◽  
Significant Inhibition ◽  
Organophosphate Pesticides ◽  
Monoamine Oxidase Activity ◽  
Mao Activity

The effects of some organophosphate pesticides, e.g. lebaycid, metacid and metasystox on the monoamine oxidase (MAO) activity in rat brain mitochondria have been studied. These pesticides cause significant inhibition of MAO activity in vitro but have negligible effects on its activity in vivo.

Effects of 3-Hydroxypyridine and Succinic Acid Derivatives on Monoamine Oxidase Activity In Vitro

2018 ◽  
Vol 52 (1) ◽  
pp. 26-29 ◽  
Author(s):  
I. A. Volchegorskii ◽  
A. I. Sinitskii ◽  
I. Yu. Miroshnichenko ◽  
L. M. Rassokhina
Keyword(s):  
Monoamine Oxidase ◽  
Succinic Acid ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity

scholarly journals Reaction-based two-photon probes for in vitro analysis and cellular imaging of monoamine oxidase activity

2012 ◽  
Vol 48 (54) ◽  
pp. 6833 ◽  
Author(s):  
Dokyoung Kim ◽  
Sunderraman Sambasivan ◽  
Hyoseok Nam ◽  
Ki Hean Kim ◽  
Jin Yong Kim ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Cellular Imaging ◽  
Monoamine Oxidase Activity ◽  
Two Photon ◽  
Vitro Analysis ◽  
In Vitro Analysis

HORMONAL ACTION ON MONOAMINE OXIDASE ACTIVITY IN RATS

1967 ◽  
Vol 45 (3) ◽  
pp. 355-362 ◽  
Author(s):  
A. Ho-Van-Hap ◽  
L. M. Babineau ◽  
L. Berlinguet
Keyword(s):  
Monoamine Oxidase ◽  
Adult Female ◽  
Oxidase Activity ◽  
Female Rats ◽  
Monoamine Oxidase Activity ◽  
Adult Rats ◽  
Young Rats ◽  
Mao Activity ◽  
Hormonal Action

Male young and adult rats were injected with thyroxin, hydrocortisone and puromycin. Monoamine oxidase (MAO) activity was studied in liver, brain, kidney, and heart with L-tryptamine-2-14C as substrate. After thyroxin treatment, heart MAO increased in young animals but decreased in adult animals. Thyroxin decreased liver MAO in adult animals. Brain MAO remained constant in all experiments, whereas kidney MAO showed a slight decrease after thyroxin injection. In young rats, puromycin did not prevent the increase in heart MAO caused by thyroxin injection. Hydrocortisone did not enhance MAO activity in liver, brain and heart. Of all organs studied, only the heart showed a marked increase of MAO with age. In female rats, thyroxin has little effect on brain and liver MAO, whereas it increases MAO activity in the heart of young and adult animals by 67% and 32% respectively. Adult female rats have twice as much heart MAO as males.

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