In vitro and in vivo effect of organophosphate pesticides on monoamine oxidase activity in rat brain

1987 ◽  
Vol 7 (10) ◽  
pp. 801-803 ◽  
Author(s):  
Maitreyi Nag ◽  
Namita Nandi
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Oxidase Activity ◽  
Brain Mitochondria ◽  
Significant Inhibition ◽  
Organophosphate Pesticides ◽  
Monoamine Oxidase Activity ◽  
Mao Activity

The effects of some organophosphate pesticides, e.g. lebaycid, metacid and metasystox on the monoamine oxidase (MAO) activity in rat brain mitochondria have been studied. These pesticides cause significant inhibition of MAO activity in vitro but have negligible effects on its activity in vivo.

In vitro and in vivo effect of chloropromazine, imipramine and lithium chloride on monoamine oxidase activity in rat brain mitochondria

1987 ◽  
Vol 7 (9) ◽  
pp. 701-704 ◽  
Author(s):  
Maitreyi Nag ◽  
Namita Nandi
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Dose Level ◽  
Lithium Chloride ◽  
Oxidase Activity ◽  
Brain Mitochondria ◽  
Monoamine Oxidase Activity ◽  
Mitochondrial Monoamine Oxidase

Chloropromazine (CPZ) and imipramine at a concentration of 1×10−3 M inhibit rat brain mitochondrial monoamine oxidase activity in vitro by 70 and 55% respectively, while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme very negligibly (4%). In vivo, these drugs at a dose level of 56 mg CPZ, 76 mg Jimipramine and 76 mg lithium chloride/Kg body wt., did not cause any observable variation from normal in brain mitochondrial monoamine oxidase activity.

Inhibitory Effect of Silkworm-Extract(SE) on Monoamine Oxidase Activity in Vitro and in Vivo

2005 ◽  
Vol 35 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Young-Kook KANG ◽  
Sang-Ho NAM ◽  
Hyung-Ok SOHN ◽  
Dong-Wook LEE
Keyword(s):  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Inhibitory Effect ◽  
Monoamine Oxidase Activity

scholarly journals In-vitro Study of Monoamine Oxidase Activity and Lipid Hyperoxidation in the Rat Brain.

1994 ◽  
Vol 64 ◽  
pp. 224
Author(s):  
M. Inagaki ◽  
K. Sasuga ◽  
C. Fukazawa ◽  
Y. Kitagawa ◽  
Y. Kiuchi ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Oxidase Activity ◽  
In Vitro Study ◽  
Vitro Study ◽  
Monoamine Oxidase Activity

scholarly journals Effect of Alkaloids Isolated fromPhyllodium pulchellumon Monoamine Levels and Monoamine Oxidase Activity in Rat Brain

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Lu Cai ◽  
Chao Wang ◽  
Xiao-kui Huo ◽  
Pei-pei Dong ◽  
Bao-jing Zhang ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Monoamine Oxidase ◽  
Rat Brain ◽  
Oxidase Activity ◽  
Folk Medicine ◽  
Spectroscopic Methods ◽  
Monoamine Oxidase Activity ◽  
Mao B ◽  
Mao Activity ◽  
Monoamines Metabolism

Phyllodium pulchellum(P. pulchellum) is a folk medicine with a significant number of bioactivities. The aim of this study was to investigate the effects displayed by alkaloids fractions, isolated from the roots ofP. pulchellum, on neurotransmitters monoamine levels and on monoamine oxidase (MAO) activity. Six alkaloids, which had indolealkylamine orβ-carboline skeleton, were obtained by chromatographic technologies and identified by spectroscopic methods such as NMR and MS. After treatment with alkaloids ofP. pulchellum, the reduction of DA levels (54.55%) and 5-HT levels (35.01%) in rat brain was observed by HPLC-FLD. The effect of alkaloids on the monoamines metabolism was mainly related to MAO inhibition, characterized by IC50values of37.35±6.41and126.53±5.39 μg/mL for MAO-A and MAO-B, respectively. The acute toxicity indicated thatP. pulchellumextract was nontoxic.

Synthesis of 2′-(1,2,3-triazoyl)-acetophenones: molecular docking and inhibition of in vitro monoamine oxidase activity

2021 ◽  
Author(s):  
Gabriel P. Costa ◽  
Ítalo F. C. Dias ◽  
Mariana G. Fronza ◽  
Evelyn M. Besckow ◽  
Jenifer Fetter ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Monoamine Oxidase ◽  
Oxidase Activity ◽  
Monoamine Oxidase Activity ◽  
Mao Activity

The synthesis of 2′-(1,2,3-triazoyl)-acetophenones by a CuAAC using thiourea as a ligand, molecular docking and MAO activity analyses were performed.

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