Bi-functional nature of nanoceria: pro-drug and drug-carrier potentiality towards receptor-mediated targeting of doxorubicin

2020 ◽  
Vol 44 (39) ◽  
pp. 17013-17026
Author(s):  
Madhura A. Damle ◽  
Varsha G. Shetty ◽  
Alok P. Jakhade ◽  
Ruchika Kaul-Ghanekar ◽  
Rajeev C. Chikate
Keyword(s):  
Targeted Delivery ◽  
Drug Carrier ◽  
Site Specific ◽  
Functional Nature

The bifunctional nature of nanoceria as pro-drug and vehicle for the site-specific targeted delivery of DOX is achieved with CeO2–(DOX–FA) nanoconjugates towards MFC-7 cells.

scholarly journals Redox Responsive Pluronic Micelle Mediated Delivery of Functional siRNA: A Modular Nano-Assembly for Targeted Delivery

2021 ◽  
Author(s):  
Sandeep Kadekar ◽  
Ganesh N. Nawale ◽  
Vignesh Kumar Rangasami ◽  
Vadim Le Joncour ◽  
Pirjo Laakkonen ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Unmet Need ◽  
Short Interfering Rna ◽  
Site Specific ◽  
Redox Responsive ◽  
Interfering Rna

There is an unmet need to develop strategies that allow site-specific delivery of short interfering RNA (siRNA) without any associated toxicity. To address this challenge, we have developed a novel...

scholarly journals Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Typhonium giganteum Drugs

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaohua Gu ◽  
Rui Cao ◽  
Fu Li ◽  
Yan Li ◽  
Hongge Jia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Graphene Oxide ◽  
Targeted Delivery ◽  
Drug Carrier ◽  
Dual Function ◽  
Natural Environments ◽  
Scanning Calorimetry ◽  
Environment Friendly ◽  
A549 Lung ◽  
Scanning Electron

In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials.

Deep Eutectic Solvent-Mediated FA-g-β-Alanine-co-PCL Drug Carrier for Sustainable and Site-Specific Drug Delivery

2018 ◽  
Vol 1 (6) ◽  
pp. 2094-2109 ◽  
Author(s):  
Periyakaruppan Pradeepkumar ◽  
Naresh Kumar Rajendran ◽  
Abdullah A. Alarfaj ◽  
Murugan A. Munusamy ◽  
Mariappan Rajan
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Deep Eutectic Solvent ◽  
Specific Drug ◽  
Site Specific

scholarly journals Fmoc-Conjugated PEG-Vitamin E2 Micelles for Tumor-Targeted Delivery of Paclitaxel: Enhanced Drug-Carrier Interaction and Loading Capacity

2014 ◽  
Vol 16 (6) ◽  
pp. 1282-1291 ◽  
Author(s):  
Yifei Zhang ◽  
Yixian Huang ◽  
Wenchen Zhao ◽  
Jianqin Lu ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Drug Carrier ◽  
Loading Capacity ◽  
Carrier Interaction

scholarly journals The Use of Heptamethine Cyanine Dyes as Drug-Conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors

2021 ◽  
Vol 11 ◽  
Author(s):  
Elizabeth Cooper ◽  
Peter J. Choi ◽  
William A. Denny ◽  
Jiney Jose ◽  
Mike Dragunow ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Drug Carrier ◽  
Cancer Therapeutics ◽  
Cyanine Dyes ◽  
Chemotherapeutic Agents ◽  
Metastatic Brain Tumors ◽  
Specific Distribution

Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by the local tumor microenvironment. Clinically approved chemotherapeutic agents have been investigated for brain neoplasms, but despite their effectiveness in peripheral cancers, failed to show therapeutic success in brain tumors. This is largely due to their poor bioavailability and specificity towards brain tumors. A targeted delivery system might improve the efficacy of the candidate compounds by increasing the retention time in the tumor tissue, and minimizing the numerous side effects associated with the non-specific distribution of the chemotherapy agent. Heptamethine cyanine dyes (HMCDs) are a class of near-infrared fluorescence (NIRF) compounds that have recently emerged as promising agents for drug delivery. Initially explored for their use in imaging and monitoring neoplasms, their tumor-targeting properties have recently been investigated for their use as drug carrier systems. This review will explore the recent developments in the tumour-targeting properties of a specific group of NIRF cyanine dyes and the preclinical evidence for their potential as drug-delivery systems in the treatment of primary and metastatic brain tumors.

scholarly journals Targeted, Site-Specific, Delivery Vehicles of Therapeutics for COVID-19 Patients. Brief Review

2020 ◽  
Vol 26 ◽  
pp. 107602962095491
Author(s):  
Nicholas Kipshidze ◽  
Patrick Iversen ◽  
Thomas R. Porter ◽  
Nodar Kipshidze ◽  
Fakiha Siddiqui ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Relative Effectiveness ◽  
Pulmonary Delivery ◽  
Delivery Mode ◽  
Systemic Delivery ◽  
Site Specific ◽  
Delivery Vehicles ◽  
Localized Delivery ◽  
Delivery Approach ◽  
Systemic Therapies

Definitive pharmacological therapies for COVID-19 have yet to be identified. Several hundred trials are ongoing globally in the hope of a solution. However, nearly all treatments rely on systemic delivery but COVID-19 damages the lungs preferentially. The use of a targeted delivery approach is reviewed where engineered products are able to reach damaged lung tissue directly, which includes catheter-based and aerosol-based approaches. In this review we have outlined various target directed approaches which include microbubbles, extracellular vesicles including exosomes, adenosine nanoparticles, novel bio-objects, direct aerosol targeted pulmonary delivery and catheter-based drug delivery with reference to their relative effectiveness for the specific lesions. Currently several trials are ongoing to determine the effectiveness of such delivery systems alone and in conjunction with systemic therapies. Such approaches may prove to be very effective in the controlled and localized COVID-19 viral lesions in the lungs and potential sites. Moreover, localized delivery offered a safer delivery mode for such drugs which may have systemic adverse effects.

Thermosensitive nanoparticle of mPEG-PTMC for oligopeptide delivery into osteoclast precursors

2020 ◽  
Vol 35 (4-5) ◽  
pp. 426-434
Author(s):  
Penghui Wang ◽  
Rong Yang ◽  
Shuai Liu ◽  
Yanhan Ren ◽  
Xin Liu ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Cell Biology ◽  
Drug Carrier ◽  
Temperature Response ◽  
Size Analysis ◽  
Poly Vinyl Alcohol ◽  
Temperature Sensitive ◽  
Peptide Drug ◽  
Trimethylene Carbonate ◽  
Model Peptide

Transmembrane delivery of biomolecules through nanoparticles plays an important role in targeted therapy. Here, we designed a simple nanoparticle for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages) by thermosensitive and biodegradable diblock copolymer monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate). The model peptide drug was encapsulated into the nanoparticle by dropping the drug carrier dissolved in dimethylsulfoxide solvent into water containing poly(vinyl alcohol) to achieve temperature response nanoparticles. Through size analysis, we found that the nanoparticles possessed a temperature-sensitive property between 30°C and 40°C. Moreover, flow cytometry and spectrofluorimetry analysis indicated that nanoparticle systems underwent significant cellular uptake. In addition, the evaluation of cell biology showed that nanoparticles have excellent biocompatibility. Thus, the results indicated that the temperature-sensitive nanoparticles have potential application value for targeted delivery of oligopeptide in the treatment process of osteoarthritis.

Self-Assembled DNA Nanocentipede as Multivalent Drug Carrier for Targeted Delivery

2016 ◽  
Vol 8 (39) ◽  
pp. 25733-25740 ◽  
Author(s):  
Wenshan Li ◽  
Xiaohai Yang ◽  
Leiliang He ◽  
Kemin Wang ◽  
Qing Wang ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Drug Carrier ◽  
Self Assembled
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