A mass spectrometry-based approach gives new insight into organotin–protein interactions

Metallomics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1702-1712
Author(s):  
Jonas M. Will ◽  
Catharina Erbacher ◽  
Michael Sperling ◽  
Uwe Karst

This study presents a complementary approach based on size exclusion chromatography and mass spectrometry to gain insight into the interactions of organotin compounds with proteins.

2017 ◽  
Vol 8 (5) ◽  
pp. 4062-4072 ◽  
Author(s):  
Michael Cammarata ◽  
Ross Thyer ◽  
Michael Lombardo ◽  
Amy Anderson ◽  
Dennis Wright ◽  
...  

Native mass spectrometry, size exclusion chromatography, and kinetic assays were employed to study trimethoprim resistance in E. coli caused by mutations P21L and W30R of dihydrofolate reductase.


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