scholarly journals Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates

2017 ◽  
Vol 8 (5) ◽  
pp. 4062-4072 ◽  
Author(s):  
Michael Cammarata ◽  
Ross Thyer ◽  
Michael Lombardo ◽  
Amy Anderson ◽  
Dennis Wright ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Size Exclusion Chromatography ◽  
Dihydrofolate Reductase ◽  
Native Mass Spectrometry ◽  
Size Exclusion ◽  
E Coli ◽  
Exclusion Chromatography

Native mass spectrometry, size exclusion chromatography, and kinetic assays were employed to study trimethoprim resistance in E. coli caused by mutations P21L and W30R of dihydrofolate reductase.

scholarly journals Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

mAbs ◽  
2015 ◽  
Vol 8 (2) ◽  
pp. 331-339 ◽  
Author(s):  
Markus Haberger ◽  
Michael Leiss ◽  
Anna-Katharina Heidenreich ◽  
Oxana Pester ◽  
Georg Hafenmair ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Size Exclusion Chromatography ◽  
Native Mass Spectrometry ◽  
Size Exclusion ◽  
Exclusion Chromatography ◽  
Rapid Characterization
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