Design of thermoresponsive hydrogels by controlling the chemistry and imprinting of drug molecules within the hydrogel for enhanced loading and smart delivery of drugs

2021 ◽  
Author(s):  
Sang-Yu Park ◽  
Seong Yeol Kim ◽  
Ji-Hye Kang ◽  
Han-Sem Kim ◽  
Ueon Sang Shin
Keyword(s):  
Drug Delivery ◽  
Molecular Imprinting ◽  
Medical Practice ◽  
Drug Loading ◽  
Suitable Method ◽  
Drug Molecules ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Thermoresponsive Hydrogels ◽  
Delivery Techniques

Various drug delivery techniques have contributed significantly to medical practice. In particular, molecular imprinting is a suitable method to increase the drug-loading efficiency in limited 3D spaces, such as hydrogels....

Combination therapeutics of doxorubicin with Fe3O4@chitosan@phytic acid nanoparticles for multi-responsive drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (91) ◽  
pp. 88248-88254 ◽  
Author(s):  
Dandan Xu ◽  
Rui Xie ◽  
Tongying Xu ◽  
Xuejie Guo ◽  
Qi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Phytic Acid ◽  
Drug Loading ◽  
Magnetic Saturation ◽  
High Drug ◽  
Ph Response ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
High Drug Loading

Fe3O4@CS nanoparticles as the precursors were encapsulated by PA, developing Fe3O4@CS@PA nanocarriers with high drug loading efficiency, outstanding magnetic saturation, remarkable pH-response and obvious inhibition to tumor cells.

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

Improving drug loading efficiency and delivery performance of micro- and nanoparticle preparations through optimising formulation variables

2013 ◽  
Vol 10 (10/11) ◽  
pp. 996 ◽  
Author(s):  
Chiao Hsi Chiang ◽  
Hossein Hosseinkhani ◽  
Wen Sheng Cheng ◽  
g Wei Chen ◽  
Chun Hsiang Wang ◽  
...  
Keyword(s):  
Drug Loading ◽  
Delivery Performance ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Formulation Variables

scholarly journals FORMULATION, OPTIMIZATION AND IN VITRO EVALUATION OF 5-FLUOROURACIL LOADED LIQUORICE CRUDE PROTEIN NANOPARTICLES FOR SUSTAINED DRUG DELIVERY USING BOX-BEHNKEN DESIGN

2021 ◽  
pp. 216-226
Author(s):  
GEETHA V. S. ◽  
MALARKODI VELRAJ
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Crude Protein ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Box Behnken Design ◽  
Sustained Drug Delivery ◽  
Drug Loading Efficiency

Objective: To formulate, optimize and evaluate 5-fluorouracil loaded liquorice crude protein nanoparticles for sustained drug delivery using Box-Behnken design. Methods: 5-fluorouracil (5-FU) loaded liquorice crude protein (LCP) nanoparticles were prepared by desolvation method using ethanol-water (1:2 ratio), Tween-80 (2%v/v) as stabilizing agent and gluteraldehyde (8% v/v) as cross linking agent. The optimization of prepared nanoparticles was carried out using Box-Behnken design with 3 factors 2 levels and 3 responses. The independent variables were A)5-FU concentration B)LCP concentration and C) sonication time while the responses were R1) Drug entrapment efficiency R2) Drug loading efficiency and R3) Particle size. The correlation between factors and responses were studied through response surface plots and mathematical equations. The nanoparticles were evaluated for FTIR, physicochemical properties like particle size and zeta potential by Photon correlation spectroscopy (PCS) and surface morphology by TEM. The entrapment efficiency, drug loading efficiency and in vitro drug release studies in PBS pH 7.4 (24 h) were carried out. The observed values were found to be in close agreement with the predicted value obtained from the optimization process. Results: 5-fluorouracil loaded LCP nanoparticles were prepared by desolvation method, the optimization was carried out by Box-Behnken design and the final formulation was evaluated for particle size (301.1 nm), zeta-potential (-25.8mV), PDI(0.226), with entrapment efficiency (64.07%), drug loading efficiency (28.54%), in vitro drug release (65.2% in 24 h) respectively. The formulated nanoparticles show Higuchi model drug release kinetics with sustained drug delivery for 24 h in pH7.4 buffer. Conclusion: The results were proved to be the most valuable for the sustained delivery of 5-Fluorouracil using liquorice crude protein as carrier. 5-FU–LCP nanoparticles were prepared using Tween-80 as stabilizing agent and gluteraldehyde as cross-linking agent to possess ideal sustained drug release characteristics.

Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency

2017 ◽  
Vol 156 ◽  
pp. 29-37 ◽  
Author(s):  
Yongpeng Hou ◽  
Chen Yao ◽  
Longbing Ling ◽  
Yawei Du ◽  
Ruiyu He ◽  
...  
Keyword(s):  
Drug Loading ◽  
High Drug ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Self Assembled ◽  
High Drug Loading

Synthesize and survey the drug loading efficiency of the porous nano silica modified by gelatin

2019 ◽  
Vol 10 (3) ◽  
pp. 035017 ◽  
Author(s):  
Uyen Vy Vo ◽  
Van Cuong Nguyen ◽  
Xuan Vu Duong Vo ◽  
Minh Khang Tan Vo ◽  
Hoang Ai Le Pham ◽  
...  
Keyword(s):  
Drug Loading ◽  
Nano Silica ◽  
Loading Efficiency ◽  
Drug Loading Efficiency

Supramolecular micellar drug delivery system based on multi-arm block copolymer for highly effective encapsulation and sustained-release chemotherapy

2019 ◽  
Vol 7 (37) ◽  
pp. 5677-5687 ◽  
Author(s):  
Li Zhang ◽  
Dongjian Shi ◽  
Chunling Shi ◽  
Tatsuo Kaneko ◽  
Mingqing Chen
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
High Drug ◽  
Release Drug ◽  
Drug Loading Efficiency ◽  
High Drug Loading

A novel multi-arm polyphosphoester-based nanomaterial provides high drug loading efficiency and sustained-release drug delivery for effective chemotherapy.

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