Droplet delivery and nebulization system using surface acoustic wave for mass spectrometry

Lab on a Chip ◽  
2020 ◽  
Vol 20 (17) ◽  
pp. 3269-3277
Author(s):  
Di Sun ◽  
Karl F. Böhringer ◽  
Matthew Sorensen ◽  
Erik Nilsson ◽  
J. Scott Edgar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sample Preparation ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Standing Wave ◽  
Piezoelectric Transducer ◽  
Wave Surface ◽  
Surface Acoustic Wave Nebulization

We present a piezoelectric transducer for standing wave surface acoustic wave nebulization (SW-SAWN) patterned with anisotropic ratchet conveyors (ARCs) to automate the sample preparation and droplet delivery.

scholarly journals Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andreas Kiontke ◽  
Mehrzad Roudini ◽  
Susan Billig ◽  
Amarghan Fakhfouri ◽  
Andreas Winkler ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Low Temperature ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Ionization Mechanism ◽  
Low Temperature Plasma ◽  
Ambient Conditions ◽  
Temperature Plasma ◽  
Plasma Ionization ◽  
Surface Acoustic Wave Nebulization

AbstractMass spectrometry coupled to low-temperature plasma ionization (LTPI) allows for immediate and easy analysis of compounds from the surface of a sample at ambient conditions. The efficiency of this process, however, strongly depends on the successful desorption of the analyte from the surface to the gas phase. Whilst conventional sample heating can improve analyte desorption, heating is not desirable with respect to the stability of thermally labile analytes. In this study using aromatic amines as model compounds, we demonstrate that (1) surface acoustic wave nebulization (SAWN) can significantly improve compound desorption for LTPI without heating the sample. Furthermore, (2) SAWN-assisted LTPI shows a response enhancement up to a factor of 8 for polar compounds such as aminophenols and phenylenediamines suggesting a paradigm shift in the ionization mechanism. Additional assets of the new technique demonstrated here are (3) a reduced analyte selectivity (the interquartile range of the response decreased by a factor of 7)—a significant benefit in non-targeted analysis of complex samples—and (4) the possibility for automated online monitoring using an autosampler. Finally, (5) the small size of the microfluidic SAWN-chip enables the implementation of the method into miniaturized, mobile LTPI probes.

scholarly journals Author Correction: Surface acoustic wave nebulization improves compound selectivity of low-temperature plasma ionization for mass spectrometry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andreas Kiontke ◽  
Mehrzad Roudini ◽  
Susan Billig ◽  
Armaghan Fakhfouri ◽  
Andreas Winkler ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Low Temperature ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Low Temperature Plasma ◽  
Temperature Plasma ◽  
Plasma Ionization ◽  
Surface Acoustic Wave Nebulization

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals Rapid Food Product Analysis by Surface Acoustic Wave Nebulization Coupled Mass Spectrometry

2018 ◽  
Vol 11 (9) ◽  
pp. 2447-2454 ◽  
Author(s):  
Thomas Schneider ◽  
Benjamin L. Oyler ◽  
Sung Hwan Yoon ◽  
Tao Liang ◽  
Gloria S. Yen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Food Product ◽  
Product Analysis ◽  
Surface Acoustic Wave Nebulization

scholarly journals Surface Acoustic Wave Nebulization of Peptides As a Microfluidic Interface for Mass Spectrometry

2010 ◽  
Vol 82 (10) ◽  
pp. 3985-3989 ◽  
Author(s):  
Scott R. Heron ◽  
Rab Wilson ◽  
Scott A. Shaffer ◽  
David R. Goodlett ◽  
Jonathan M. Cooper
Keyword(s):  
Mass Spectrometry ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Surface Acoustic Wave Nebulization

Polydimethylsiloxane microchannel coupled to surface acoustic wave nebulization mass spectrometry

2016 ◽  
Vol 30 (8) ◽  
pp. 1096-1100 ◽  
Author(s):  
Gloria S. Yen ◽  
J. Scott Edgar ◽  
Sung Hwan Yoon ◽  
Yue Huang ◽  
Scott R. Heron ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Surface Acoustic Wave Nebulization

Paper-Based Microfluidic Surface Acoustic Wave Sample Delivery and Ionization Source for Rapid and Sensitive Ambient Mass Spectrometry

2011 ◽  
Vol 83 (9) ◽  
pp. 3260-3266 ◽  
Author(s):  
Jenny Ho ◽  
Ming K. Tan ◽  
David B. Go ◽  
Leslie Y. Yeo ◽  
James R. Friend ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Acoustic Wave ◽  
Surface Acoustic Wave ◽  
Ambient Mass Spectrometry ◽  
Ionization Source
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