To shift, or not to shift: adequate selection of an internal standard in mass-shift approaches using tandem ICP-mass spectrometry (ICP-MS/MS)

2021 ◽  
Author(s):  
Eduardo Bolea-Fernandez ◽  
Ana Rua-Ibarz ◽  
Martin Resano ◽  
Frank Vanhaecke
Keyword(s):  
Mass Spectrometry ◽  
Matrix Effects ◽  
Internal Standard ◽  
Mass Shift ◽  
Icp Ms ◽  
Potential Matrix ◽  
Icp Mass Spectrometry ◽  
New Generation ◽  
Selection Of

The use of an internal standard to correct for potential matrix effects and instrument instability is common practice in ICP-MS. However, with the introduction of a new generation of ICP-MS...

scholarly journals An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2894 ◽  
Author(s):  
Song-Tao Dong ◽  
Ying Li ◽  
Hao-Tian Yang ◽  
Yin Wu ◽  
Ya-Jing Li ◽  
...  
Keyword(s):  
Matrix Effects ◽  
Internal Standard ◽  
Ultra Performance Liquid Chromatography ◽  
Rat Plasma ◽  
Analysis Method ◽  
T790m Mutation ◽  
Flight Mass Spectrometry ◽  
Relative Standard ◽  
New Generation ◽  
Tof Ms

Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors. In this research, an original analysis method was established for the quantification of osimertinib by ultra-performance liquid chromatography with time of flight mass spectrometry (UPLC-TOF-MS) in rat plasma. After protein precipitation with acetonitrile and sorafinib (internal standard, IS), they were chromatographed through a Waters XTerra MS C18 column. The mobile phase was acetonitrile and water (including 0.1% ammonia). The relative standard deviation (RSD) of the intra- and inter-day results ranged from 5.38 to 9.76% and from 6.02 to 9.46%, respectively, and the extraction recovery and matrix effects were calculated to range from 84.31 to 96.14% and from 91.46 to 97.18%, respectively. The results illustrated that the analysis method had sufficient specificity, accuracy and precision. Meanwhile, the UPLC-TOF-MS method for osimertinib was successfully applied into the pharmacokinetics of SD rats.

scholarly journals Gd Matrix Effects on Eu Isotope Fractionation in Geological Rocks Using MC-ICP-MS: Optimizing Europium Isotope Ratio Measurements in Geological Samples

2021 ◽  
Author(s):  
Seung-Gu Lee ◽  
Tsuyoshi Tanaka
Keyword(s):  
Isotope Ratio ◽  
Isotope Fractionation ◽  
Matrix Effects ◽  
Internal Standard ◽  
Geological Samples ◽  
Chemical Reagent ◽  
True Value ◽  
Icp Ms ◽  
Silicate Rocks ◽  
Isotope Ratio Measurements

<p></p><p>Eu has only two isotopes (151Eu and 153 Eu). Eu and Gd are one of the rare earth elements that are very difficult to completely separate from each other. Eu isotope ratio can be determined by MC-ICP-MS using internal Sm or Gd spikes to correct for mass discrimination. NIST3117a ultrapure chemical reagent shows almost no Eu isotope fractionation regardless of the kind of normalization isotope pair. However, Eu isotope ratio in the silicate rocks was effected by Gd matrix during MC-ICP-MS measurement if a trace amount of Gd impurity remains in the purified Eu fraction. In this report, we tried to determine optimizing conditions for precise and accurate Europium isotope ratio measurements in geological samples using MC-ICP-MS. The pure Eu fraction with almost no Gd matrix separated from geological samples and NIST3117a ultrapure chemical reagent show almost same degree of Eu isotope fractionation regardless of the kind of normalization isotope pair. However, Eu isotope ratio in the silicate rocks was effected by Gd matrix during MC-ICP-MS measurement using if 154 Gd interference relative to 154 Sm as internal standard is more than ca. 0.1%. Particularly, highly fractionated granite and high silica volcanic rock with extremely low Eu concentration compared to Gd require high – purity Eu separation with a high recovery rate to obtain the true value of the Eu isotope fractionation in the geological rocks. <br></p><br><p></p>

scholarly journals Nanoplastic Labelling with Metal Probes: Analytical Strategies for Their Sensitive Detection and Quantification by ICP Mass Spectrometry

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7093
Author(s):  
Lucile Marigliano ◽  
Bruno Grassl ◽  
Joanna Szpunar ◽  
Stéphanie Reynaud ◽  
Javier Jiménez-Lamana
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Analytical Techniques ◽  
Inductively Coupled ◽  
Advantages And Disadvantages ◽  
Promising Tool ◽  
Icp Ms ◽  
Analytical Strategies ◽  
Icp Mass Spectrometry ◽  
Detection And Quantification

The detection and quantification of nanoplastics in aquatic environments is one of the major challenges in environmental and analytical research nowadays. The use of common analytical techniques for this purpose is not only hampered by the size of nanoplastics, but also because they are mainly made of carbon. In addition, the expected concentrations in environmental samples are below the detection limit of the majority of analytical techniques. In this context, the great detection capabilities of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in its Single Particle mode (SP-ICP-MS) have made of this technique a good candidate for the analysis of nanoplastics. Since the monitoring of carbon by ICP-MS faces several difficulties, the use of metal tags, taking advantage of the great potential of nanoplastics to adsorb chemical compounds, has been proposed as an alternative. In this perspectives paper, three different strategies for the analysis of polystyrene (PS) nanoplastics by SP-ICP-MS based on the use of metals species (ions, hydrophobic organometallic compound, and nanoparticles) as tags are presented and discussed. Advantages and disadvantages of each strategy, which rely on the labelling process, are highlighted. The metal nanoparticles labelling strategy is shown as a promising tool for the detection and quantification of nanoplastics in aqueous matrices by SP-ICP-MS.

scholarly journals Ultraperformance Liquid Chromatography–Tandem Mass Spectrometry Assay for Iohexol in Human Serum

2009 ◽  
Vol 55 (6) ◽  
pp. 1196-1202 ◽  
Author(s):  
Thomas M Annesley ◽  
Larry T Clayton
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Serum ◽  
Matrix Effects ◽  
Multiple Reaction Monitoring ◽  
Internal Standard ◽  
Structural Analog ◽  
Limit Of Quantification ◽  
Iodinated Contrast ◽  
Liquid Chromatography Tandem Mass

Abstract Background: Iohexol is an iodinated contrast dye that has been shown to be useful in the estimation of glomerular filtration rate (GFR) in patients with suspected renal insufficiency. We developed and validated an ultraperformance liquid chromatography (UPLC)–triple quadrupole mass spectrometry (MS/MS) assay for quantifying iohexol in human serum. Methods: Sample preparation involved dilution of 50 μL serum with 400 μL water, followed by protein precipitation with zinc sulfate and methanol containing the structural analog ioversol as the internal standard. After 1:20 dilution of the supernatant with water, 5 μL was injected into the UPLC-MS/MS system. Chromatography was performed using a Waters Oasis HLB 5-μm particle size, 2.1 × 20 mm column maintained at 50 °C. We used a 1-step acetonitrile/0.1% formic acid gradient to elute the compounds of interest at a common retention time of 0.96 min. The multiple reaction monitoring transitions used for integration and quantification were m/z 821.7→803.7 for iohexol and m/z 807.9→589.0 for ioversol in the electrospray positive ionization mode. Results: The assay was linear from 2.5 mg/L (lower limit of quantification) to 1500 mg/L iohexol, with a mean extraction efficiency of &gt;99%. Recovery of nominal target concentrations was 99%–102%. Interassay imprecision ranged from 7.9% at a concentration of 2.5 mg/L to 4.1% at 1000 mg/L. Ion suppression studies showed no matrix effects on the ionization of the 2 compounds. Conclusions: This rapid UPLC-MS/MS method can be successfully used for quantifying iohexol in human serum. .

A new practical isobaric interference correction model for the in situ Hf isotopic analysis using laser ablation-multi-collector-ICP-mass spectrometry of zircons with high Yb/Hf ratios

2019 ◽  
Vol 34 (6) ◽  
pp. 1223-1232 ◽  
Author(s):  
Hai-Ou Gu ◽  
He Sun ◽  
Fangyue Wang ◽  
Can Ge ◽  
Taofa Zhou
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Isotopic Analysis ◽  
Correction Model ◽  
Isobaric Interference ◽  
Interference Correction ◽  
Icp Ms ◽  
Icp Mass Spectrometry

An isobaric interference correction model was proposed for the in situ Hf isotopic analysis of zircons with high Yb/Hf ratios using LA-MC-ICP-MS.

A More Accurate Molar Mass of Silicon via High Resolution MC-ICP-Mass Spectrometry

2014 ◽  
Vol 228 (4-5) ◽  
Author(s):  
Axel Pramann ◽  
Olaf Rienitz ◽  
Janine Noordmann ◽  
Bernd Güttler ◽  
Detlef Schiel
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Inductively Coupled Plasma ◽  
Molar Mass ◽  
Silicon Crystal ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Icp Mass Spectrometry

AbstractHigh resolution multicollector inductively coupled plasma mass spectrometry (HR-MC-ICP-MS) was applied for the determination of the isotopic composition and molar mass of a silicon crystal material (“Si28”) highly enriched in the

High-precision isotopic analysis of Cu in blood serum via multi-collector ICP-mass spectrometry for clinical investigation: steps towards improved robustness and higher sample throughput

2017 ◽  
Vol 32 (3) ◽  
pp. 597-608 ◽  
Author(s):  
Sara Lauwens ◽  
Marta Costas-Rodríguez ◽  
Hans Van Vlierberghe ◽  
Frank Vanhaecke
Keyword(s):  
Mass Spectrometry ◽  
Isotopic Composition ◽  
Blood Serum ◽  
Diurnal Variation ◽  
Clinical Investigation ◽  
Isotopic Analysis ◽  
Clinical Context ◽  
Sample Throughput ◽  
Icp Ms ◽  
Icp Mass Spectrometry

A procedure for Cu isolation from serum prior to MC-ICP-MS measurements was developed and applied in a clinical context. The serum Cu isotopic composition does not show diurnal variation.

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