A critical review of the analysis of dried blood spots for characterizing human exposure to inorganic targets using methods based on analytical atomic spectrometry

2020 ◽  
Vol 35 (10) ◽  
pp. 2092-2112 ◽  
Author(s):  
Patrick J. Parsons ◽  
Aubrey L. Galusha ◽  
Yuxia Cui ◽  
Elaine M. Faustman ◽  
Jill C. Falman ◽  
...  
Keyword(s):  
Critical Review ◽  
Human Exposure ◽  
Dried Blood Spots ◽  
Atomic Spectrometry ◽  
Blood Spots ◽  
Analytical Atomic Spectrometry

Several researchers have reported using dried blood spots to measure inorganic targets but with varying degrees of success.

scholarly journals Bridging the gap between sample collection and laboratory analysis: using dried blood spots to identify human exposure to chemical agents

2016 ◽  
Author(s):  
Elizabeth I. Hamelin ◽  
Thomas A. Blake ◽  
Jonas W. Perez ◽  
Brian S. Crow ◽  
Rebecca L. Shaner ◽  
...  
Keyword(s):  
Human Exposure ◽  
Dried Blood Spots ◽  
Laboratory Analysis ◽  
Sample Collection ◽  
Blood Spots ◽  
Chemical Agents

Therapeutic drug monitoring (TDM) of the recent antipsychotic ziprasidone in dried blood spots (DBS) and plasma

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
L Mercolini ◽  
G Fulgenzi ◽  
M Melis ◽  
G Boncompagni ◽  
LJ Albers ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Dried Blood Spots ◽  
Therapeutic Drug ◽  
Blood Spots

scholarly journals Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Niclas Roxhed ◽  
Annika Bendes ◽  
Matilda Dale ◽  
Cecilia Mattsson ◽  
Leo Hanke ◽  
...  
Keyword(s):  
Immune Response ◽  
Dried Blood Spots ◽  
Serological Testing ◽  
S Protein ◽  
Individual Level ◽  
Blood Spots

AbstractSerological testing is essential to curb the consequences of the COVID-19 pandemic. However, most assays are still limited to single analytes and samples collected within healthcare. Thus, we establish a multianalyte and multiplexed approach to reliably profile IgG and IgM levels against several versions of SARS-CoV-2 proteins (S, RBD, N) in home-sampled dried blood spots (DBS). We analyse DBS collected during spring of 2020 from 878 random and undiagnosed individuals from the population in Stockholm, Sweden, and use classification approaches to estimate an accumulated seroprevalence of 12.5% (95% CI: 10.3%–14.7%). This includes 5.4% of the samples being IgG+IgM+ against several SARS-CoV-2 proteins, as well as 2.1% being IgG−IgM+ and 5.0% being IgG+IgM− for the virus’ S protein. Subjects classified as IgG+ for several SARS-CoV-2 proteins report influenza-like symptoms more frequently than those being IgG+ for only the S protein (OR = 6.1; p < 0.001). Among all seropositive cases, 30% are asymptomatic. Our strategy enables an accurate individual-level and multiplexed assessment of antibodies in home-sampled blood, assisting our understanding about the undiagnosed seroprevalence and diversity of the immune response against the coronavirus.

Nontargeted Mass Spectrometry of Dried Blood Spots for Interrogation of the Human Circulating Metabolome

2021 ◽  
Author(s):  
Casey Ward ◽  
Shriram Nallamshetty ◽  
Jeramie D. Watrous ◽  
Eowyn Acres ◽  
Tao Long ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Dried Blood Spots ◽  
Blood Spots
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