scholarly journals Anredera cordifolia extract enhances learning and memory in senescence-accelerated mouse-prone 8 (SAMP8) mice

2021 ◽  
Author(s):  
Eri Sumiyoshi ◽  
Michio Hashimoto ◽  
Shahdat Hossain ◽  
Kentaro Matsuzaki ◽  
Rafiad Islam ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse

Anredera cordifolia extract increased learning and memory by enhancing levels of hippocampal BDNF, PSD95, NR2A, and p-CREB in SAMP8 mice.

scholarly journals Icaritin Improves Memory and Learning Ability by Decreasing BACE-1 Expression and the Bax/Bcl-2 Ratio in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Yuan-Yuan Li ◽  
Nan-Qu Huang ◽  
Fei Feng ◽  
Ying Li ◽  
Xiu-Mei Luo ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Chinese Herb ◽  
Treated Group ◽  
Learning Ability ◽  
Control Group ◽  
Spatial Learning And Memory ◽  
Therapeutic Benefits ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse ◽  
Bace 1

Icaritin (ICT) is the main component in the traditional Chinese herb Epimedium, and it has been shown to have anti-Alzheimer’s disease (AD) effects, but its neuroprotective effects and the pharmacological mechanisms are unclear. In the present study, senescence-accelerated mouse prone 8 (SAMP8) mice were randomly divided into a model group and an ICT-treated group. Learning and memory abilities were detected by the Morris water maze assay, and the expression of amyloid beta protein (Aβ) and β-site APP cleavage enzyme 1 (BACE1) was determined by Western blotting and polymerase chain reaction (PCR). Histological changes in CA1 and CA3 were detected by hematoxylin-eosin staining (H&E staining), and the immunohistochemical analysis was used to detect the expression and localization of Bax and Bcl-2. The results showed that compared with the SAMP8 mice, the ICT-treated SAMP8 mice showed improvements in spatial learning and memory retention. In addition, the number of necrotic cells and the morphological changes in CA1 and CA3 areas were significantly alleviated in the group of ICT-treated SAMP8 mice, and the expression of BACE1, Aβ1-42 levels, and the Bax/Bcl-2 ratio in the hippocampus was obviously decreased in the ICT-treated group compared with the control group. The results demonstrated that ICT reduced BACE-1 levels, the contents of Aβ1-42, and the Bax/Bcl-2 ratio, suggesting that ICT might have potential therapeutic benefits by delaying or modifying the progression of AD.

scholarly journals Microalgae Aurantiochytrium Sp. Increases Neurogenesis and Improves Spatial Learning and Memory in Senescence-Accelerated Mouse-Prone 8 Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Kazunori Sasaki ◽  
Noelia Geribaldi-Doldán ◽  
Qingqing Wu ◽  
Julie Davies ◽  
Francis G. Szele ◽  
...  
Keyword(s):  
Stem Cells ◽  
Learning And Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Amyloid Β ◽  
Spatial Learning And Memory ◽  
And Function ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse

Much attention has recently been focused on nutraceuticals, with minimal adverse effects, developed for preventing or treating neurological diseases such as Alzheimer's disease (AD). The present study was conducted to investigate the potential effect on neural development and function of the microalgae Aurantiochytrium sp. as a nutraceutical. To test neuroprotection by the ethanol extract of Aurantiochytrium (EEA) and a derivative, the n-Hexane layer of EEA (HEEA), amyloid-β-stimulated SH-SY5Y cells, was used as an in vitro AD model. We then assessed the potential enhancement of neurogenesis by EEA and HEEA using murine ex vivo neurospheres. We also administered EEA or HEEA to senescence-accelerated mouse-prone 8 (SAMP8) mice, a non-transgenic strain with accelerated aging and AD-like memory loss for evaluation of spatial learning and memory using the Morris water maze test. Finally, we performed immunohistochemical analysis for assessment of neurogenesis in mice administered EEA. Pretreatment of SH-SY5Y cells with EEA or the squalene-rich fraction of EEA, HEEA, ameliorated amyloid-β-induced cytotoxicity. Interestingly, only EEA-treated cells showed a significant increase in cell metabolism and intracellular adenosine triphosphate production. Moreover, EEA treatment significantly increased the number of neurospheres, whereas HEEA treatment significantly increased the number of β-III-tubulin+ young neurons and GFAP+ astrocytes. SAMP8 mice were given 50 mg/kg EEA or HEEA orally for 30 days. EEA and HEEA decreased escape latency in the Morris water maze in SAMP8 mice, indicating improved memory. To detect stem cells and newborn neurons, we administered BrdU for 9 days and measured BrdU+ cells in the dentate gyrus, a neurogenic stem cell niche of the hippocampus. In SAMP8 mice, EEA rapidly and significantly increased the number of BrdU+GFAP+ stem cells and their progeny, BrdU+NeuN+ mature neurons. In conclusion, our data in aggregate indicate that EEA and its constituents could be developed into a nutraceutical for promoting brain health and function against several age-related diseases, particularly AD.

scholarly journals Mechanism of anti-dementia effects of mangiferin in a senescence accelerated mouse (SAMP8) model

2019 ◽  
Vol 39 (9) ◽  
Author(s):  
Zhengcai Du ◽  
Fangcao Fanshi ◽  
Yu-Heng Lai ◽  
Jung-Ren Chen ◽  
Erwei Hao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Learning And Memory ◽  
Hippocampal Neurons ◽  
Amyloid Β ◽  
Memory Retention ◽  
Samp8 Mouse ◽  
Mango Leaves ◽  
Samp8 Mice ◽  
The Brain ◽  
Senescence Accelerated Mouse

Abstract Mangiferin (2-β-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one), a xanthanoid, is one of the major compounds isolated from mango leaves and bark fruit. Previous studies have identified several properties of mangiferin, such as preventing microbial growth, reducing oxidative stress and helping reduce risk of diabetes. The aim of the present study is to explore the potential anti-dementia effects of Mangiferin in a senescence-accelerated mouse prone 8 (SAMP8) mouse model. Morris water maze (MWM) test showed that mangiferin significantly improved the learning and memory retention in SAMP8 mice. In addition, mangiferin reduced the damage in hippocampal neurons and mitochondria, and decreased the expression of amyloid-β (Aβ1-40 and Aβ1-42); however, no influence on the expression of amyloid precursor protein (APP) within the brain of SAMP8 mice. Moreover, Mangiferin inhibited lipid peroxidation (LPO). In conclusion, we provided evidences to show that mangiferin significantly restored the learning and memory impairment in the SAMP8 mouse model, and reduced the pathological injury in hippocampal by modulating lipid oxidation and amyloid-β deposition in the brain.

scholarly journals Pathological and non-pathological aging, SAMP8 and SAMR1. What do hippocampal neuronal populations tell us?

2019 ◽  
Author(s):  
MJ Lagartos-Donate ◽  
J Gonzáles-Fuentes ◽  
P Marcos-Rabal ◽  
R Insausti ◽  
MM Arroyo-Jiménez
Keyword(s):  
Learning And Memory ◽  
Hippocampal Formation ◽  
Neurological Diseases ◽  
Accelerated Aging ◽  
Neural Population ◽  
Neuronal Populations ◽  
Pathological Aging ◽  
Local Circuitry ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse

ABSTRACTAlterations of cognitive processes and memory are one of the most important manifestations related to aging. However, not all memory types are affected in the same way. Learning and spatial memory are susceptible to these changes. The hippocampus represents the anatomical substrate of this type of memory, affected by structural and functional alterations along the normal aging and neurological diseases such as Alzheimer’s disease, Parkinson’s, schizophrenia and epilepsy. Some of the alterations related to aging are associated with alterations in the hippocampal interneuron populations and with an increase in excitability in the hippocampal circuit.In order to understand better the underlying processes in normal and pathological aging mechanisms, a murine model (Senescence-Accelerated Mouse Prone, SAMP8) and its respective controls (Senescence-Accelerated Mouse Resistant, SAMR1) have been used. While SAMP8 is a naturally occurring mouse line that displays a phenotype of accelerated aging with learning and memory impairment and these changes of learning and memory might be linked to some alterations in neuronal populations of the hippocampus. Thus, we analyzed the distribution and density of PV, CR and STT interneurons in the hippocampus of young and old mice as well as possible morphological and cholinergic changes in hippocampal formation. Comparing SAMR1 and SAMP8 we did not find any neural population that was specifically affected by aging in both groups. Interestingly, CR immunoreactivity and STT immunoreactivity showed changes in SAMP8 mice when they were compared to their controls. In SAMP8 CR+ and STT+ neurons decreased significantly along aging which suggests that CR and STT interneurons play a more important role than PV neurons in the pathological aging of the brain. In the case of SAMP8 mice the neural changes might be related to changes of the cholinergic system that might be affecting the wiring into the hippocampus formation through the perforant pathway. Further studies of this local circuitry will help to comprehend better how different inputs into these neural populations of the hippocampus could be affecting the development of neurodegerative diseases.

scholarly journals Erinacine A-Enriched Hericium erinaceus Mycelium Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3659
Author(s):  
Li-Ya Lee ◽  
Wayne Chou ◽  
Wan-Ping Chen ◽  
Ming-Fu Wang ◽  
Ying-Ju Chen ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Active Avoidance ◽  
Brain Aging ◽  
Cognitive Disability ◽  
Neuroprotective Effects ◽  
Hericium Erinaceus ◽  
Age Related ◽  
Erinacine A ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse

There have been many reports on the neuroprotective effects of Hericium erinaceus mycelium, in which the most well-known active compounds found are diterpenoids, such as erinacine A. Previously, erinacine A-enriched Hericeum erinaceus mycelium (EAHEM) was shown to decrease amyloid plaque aggregation and improve cognitive disability in Alzheimer’s disease model APP/PS1 mice. However, its effects on brain aging have not yet been touched upon. Here, we used senescence accelerated mouse prone 8 (SAMP8) mice as a model to elucidate the mechanism by which EAHEM delays the aging of the brain. Three-month-old SAMP8 mice were divided into three EAHEM dosage groups, administered at 108, 215 and 431 mg/kg/BW/day, respectively. During the 12th week of EAHEM feeding, learning and memory of the mice were evaluated by single-trial passive avoidance and active avoidance test. After sacrifice, the amyloid plaques, induced nitric oxidase synthase (iNOS) activity, thiobarbituric acid-reactive substances (TBARS) and 8-OHdG levels were analyzed. We found that the lowest dose of 108 mg/kg/BW EAHEM was sufficient to significantly improve learning and memory in the passive and active avoidance tests. In all three EAHEM dose groups, iNOS, TBARS and 8-OHdG levels all decreased significantly and showed a dose-dependent response. The results indicate that EAHEM improved learning and memory and delayed degenerative aging in mice brains.

The Antioxidant Resveratrol from Polygonum Cuspidatum Reverses Memory Impairment and Brain Oxidative Stress in SAMP8 Mice

2011 ◽  
Vol 422 ◽  
pp. 470-473
Author(s):  
Gui Shan Liu ◽  
Ze Sheng Zhang ◽  
Bo Yang ◽  
Wei He
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Open Field ◽  
Field Test ◽  
Memory Impairment ◽  
Open Field Test ◽  
Pharmacological Action ◽  
Age Related ◽  
Brain Oxidative Stress ◽  
Samp8 Mice

Resveratrol (RVT) is a phytoalexin polyphenolic compound found in various plants, including grapes, berries and peanuts. Recently, studies have documented various health benefits of resveratrol including cardiovascular and cancer-chemopreventive properties. The aim of the present study was to demonstrate the effects of resveratrol on the learning and memory impairment. The senescence-accelerated mice (SAM) were introgastric gavage administrated resveratrol (25,100mg/(kg•bw)) for 60 days. The learning and memory behavior was assessed using open-field test while the parameters of oxidative stress assessed were malondialdehyde (MDA) and superoxide dismutases (SOD).The results showed that resveratrol significantly improved the learning and memory ability in open-field test. Further investigation showed that resveratrol restored SOD levels, but decreased MDA level in the mouce brain. These results indicated that the pharmacological action of RVT may offer a novel therapeutic strategy for the treatment of age-related conditions.

scholarly journals Longitudinal Performance of Senescence Accelerated Mouse Prone-Strain 8 (SAMP8) Mice in an Olfactory-Visual Water Maze Challenge

2018 ◽  
Vol 12 ◽  
Author(s):  
Virginie Lam ◽  
Ryusuke Takechi ◽  
Matthew A. Albrecht ◽  
Zachary John D'Alonzo ◽  
Liam Graneri ◽  
...  
Keyword(s):  
Water Maze ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse
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