Neuroprotective effects of forsythiaside on learning and memory deficits in senescence-accelerated mouse prone (SAMP8) mice

2013 ◽  
Vol 105 ◽  
pp. 134-141 ◽  
Author(s):  
Hong-Mei Wang ◽  
Li-Wei Wang ◽  
Xin-Min Liu ◽  
Chang-Lu Li ◽  
Shu-Ping Xu ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Memory Deficits ◽  
Neuroprotective Effects ◽  
Learning And Memory Deficits ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse

Genetic study of learning and memory deficits in SAMP8 mice

2004 ◽  
Vol 1260 ◽  
pp. 353-356 ◽  
Author(s):  
Koji Tomobe ◽  
Masaharu Isobe ◽  
Masanobu Sawada ◽  
Yasunobu Okuma ◽  
Yasuyuki Nomura
Keyword(s):  
Learning And Memory ◽  
Genetic Study ◽  
Memory Deficits ◽  
Learning And Memory Deficits ◽  
Samp8 Mice

scholarly journals Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sheng Wang ◽  
Wei Jiang ◽  
Ting Ouyang ◽  
Xiu-Yin Shen ◽  
Fen Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Transgenic Mice ◽  
Learning And Memory ◽  
Inflammatory Responses ◽  
Memory Deficits ◽  
Public Health Issue ◽  
High Dose ◽  
Neuroprotective Effects ◽  
Gut Dysbiosis ◽  
Learning And Memory Deficits

AbstractAlzheimer’s disease (AD) is a complex disorder influenced by both genetic and environmental components and has become a major public health issue throughout the world. Oxidative stress and inflammation play important roles in the evolution of those major pathological symptoms. Jatrorrhizine (JAT), a main component of a traditional Chinese herbal, coptidis rhizome, has been shown to have neuroprotective effects and we previously showed that it is also able to clear oxygen free radicals and reduce inflammatory responses. In this study, we demonstrated that JAT administration could alleviate the learning and memory deficits in AD. Furthermore, we also found that JAT treatment reduced the levels of Aβ plaques in the cortex and hippocampus of APP/PS1 double-transgenic mice. Other studies suggest that there are gut microbiome alterations in AD. In order to explore the underlying mechanisms between gut microbiota and AD, DNA sequencing for 16s rDNA V3-V4 was performed in fecal samples from APP/PS1 transgenic mice and C57BL/6 wild-type (WT) mice. Our results indicated that APP/PS1 mice showed less Operational Taxonomic Units (OTUs) abundance in gut microbiota than WT mice and with different composition. Furthermore, JAT treatment enriched OTUs abundance and alpha diversity in APP/PS1 mice compared to WT mice. High dose of JAT treatment altered the abundance of some specific gut microbiota such as the most predominant phylum Firmicutes and Bacteroidetes in APP/PS1 mice. In conclusion, APP/PS1 mice display gut dysbiosis, and JAT treatment not only improved the memory deficits, but also regulated the abundance of the microbiota. This may provide a therapeutic way to balance the gut dysbiosis in AD patients.

Dihydroartemisinin Induces O-GlcNAcylation and Improves Cognitive Function in a Mouse Model of Tauopathy

2021 ◽  
pp. 1-10
Author(s):  
Lei Xia ◽  
Yayan Pang ◽  
Junjie Li ◽  
Bin Wu ◽  
Yehong Du ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Mouse Model ◽  
Learning And Memory ◽  
Protein Misfolding ◽  
Memory Deficits ◽  
Long Term Potentiation ◽  
Electrophysiological Recording ◽  
Tau Pathology ◽  
Neuroprotective Effects ◽  
Learning And Memory Deficits

Background: Tauopathies are a group of neurodegenerative disorders, including Alzheimer’s disease (AD) and frontotemporal lobar degeneration with tau pathology. Hyperphosphorylation modification promotes tau protein misfolding and aggregation into neurofibrillary tangles, leading to impairments of synaptic plasticity and learning and memory. However, very limited therapeutic strategies are available. Objective: In the present study, we wanted to investigate the potential effects of Dihydroartemisinin (DHA) on tauopathies. Methods: We constructed adeno-associated virus carrying hTau cDNA (AAVhTau) to establish a mouse model of tauopathy through intrahippocampal microinjection. Using a combination of behavioral test, electrophysiological recording, and western blotting assay, we examined the neuroprotective effects of DHA on learning and memory deficits in mice with tauopathy. Results: DHA improved learning and memory and increased hippocampal CA1 long-term potentiation (LTP) in mice overexpressed human tau (hTau) in the hippocampus. More importantly, further study revealed that DHA could induce protein O-GlcNAcylation modification and reduce protein phosphorylation. O-GlcNAc transferase inhibitor alloxan could suppress DHA-induced protein O-GlcNAcylation, and subsequently prevent therapeutic effect of DHA on the deficits of learning and memory as well as synaptic plasticity in hTau mice. Conclusion: These results indicate that DHA may exert neuroprotective role in tauopathy through a crosstalk between O-GlcNAcylation and phosphorylation, suggesting a potential therapeutic for learning and memory deficits associated with tau pathology.

Genetic analysis of learning and memory deficits in senescence-accelerated mouse (SAM)

2005 ◽  
Vol 84 (4) ◽  
pp. 505-510 ◽  
Author(s):  
K TOMOBE ◽  
M ISOBE ◽  
Y OKUMA ◽  
K KITAMURA ◽  
Y OKETANI ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Learning And Memory ◽  
Memory Deficits ◽  
Learning And Memory Deficits ◽  
Senescence Accelerated Mouse

scholarly journals Erinacine A-Enriched Hericium erinaceus Mycelium Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3659
Author(s):  
Li-Ya Lee ◽  
Wayne Chou ◽  
Wan-Ping Chen ◽  
Ming-Fu Wang ◽  
Ying-Ju Chen ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Active Avoidance ◽  
Brain Aging ◽  
Cognitive Disability ◽  
Neuroprotective Effects ◽  
Hericium Erinaceus ◽  
Age Related ◽  
Erinacine A ◽  
Samp8 Mice ◽  
Senescence Accelerated Mouse

There have been many reports on the neuroprotective effects of Hericium erinaceus mycelium, in which the most well-known active compounds found are diterpenoids, such as erinacine A. Previously, erinacine A-enriched Hericeum erinaceus mycelium (EAHEM) was shown to decrease amyloid plaque aggregation and improve cognitive disability in Alzheimer’s disease model APP/PS1 mice. However, its effects on brain aging have not yet been touched upon. Here, we used senescence accelerated mouse prone 8 (SAMP8) mice as a model to elucidate the mechanism by which EAHEM delays the aging of the brain. Three-month-old SAMP8 mice were divided into three EAHEM dosage groups, administered at 108, 215 and 431 mg/kg/BW/day, respectively. During the 12th week of EAHEM feeding, learning and memory of the mice were evaluated by single-trial passive avoidance and active avoidance test. After sacrifice, the amyloid plaques, induced nitric oxidase synthase (iNOS) activity, thiobarbituric acid-reactive substances (TBARS) and 8-OHdG levels were analyzed. We found that the lowest dose of 108 mg/kg/BW EAHEM was sufficient to significantly improve learning and memory in the passive and active avoidance tests. In all three EAHEM dose groups, iNOS, TBARS and 8-OHdG levels all decreased significantly and showed a dose-dependent response. The results indicate that EAHEM improved learning and memory and delayed degenerative aging in mice brains.

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