Biogenic Selenium nanoparticles by Lactobacillus casei ATCC 393 alleviate the intestinal permeability, mitochondrial dysfunction and mitophagy induced by oxidative stress

2021 ◽  
Author(s):  
Shuqi Yan ◽  
Lei Qiao ◽  
Xina Dou ◽  
Xiao fan Song ◽  
Yue Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Mitochondrial Dysfunction ◽  
Trace Element ◽  
Lactobacillus Casei ◽  
Biological Properties ◽  
Essential Trace Element ◽  
Low Toxicity ◽  
High Bioavailability ◽  
Biogenic Selenium Nanoparticles

Selenium (Se) is an essential trace element. Nano-selenium obtained attractive attention due to its various biological properties especially strong antioxidant activity, high bioavailability, and low toxicity. Our previous studies demonstrated...

scholarly journals BIOGENIC SELENIUM NANOPARTICLES FOR THEIR THERAPEUTIC APPLICATION

2019 ◽  
pp. 4-9
Author(s):  
AWANISH KUMAR ◽  
KUMAR SURANJIT PRASAD
Keyword(s):  
Trace Element ◽  
Environmental Remediation ◽  
Pharmaceutical Research ◽  
Selenium Nanoparticles ◽  
Elemental Selenium ◽  
Essential Trace Element ◽  
Natural Ecosystems ◽  
Anticancer Efficacy ◽  
Living Organisms ◽  
Biogenic Selenium Nanoparticles

Biosynthesis is an eloquent, safe, biocompatible, eco-friendly, and recyclable way of preparing selenium nanoparticles (SeNPs). Selenium occurs in multiple oxidation states, for example, +6, +4, 0, or −2. Selenium (Se) is an essential trace element with a very narrow margin between the lowest acceptable levels of intake and toxicity. Selenium is an essential trace element required for all living organisms. Despite its essentiality, selenium is a potentially toxic element to natural ecosystems due to its bioaccumulation potential that is why it is biologically available in the environment. Selenium is a trace element commonly found in materials of the earth’s crust, and it is essential for humans, animals, and plants. Oxyanions of selenium, that is selenite and selenate, are biologically available. Selenium in the form of selenate ion (SeO42−) is more toxic to most organisms than selenite (SeO32−). Contrarily, elemental selenium (Se0) is inOsoluble and less toxic in comparison to other forms of selenium. Nanoselenium (Se0) in the range of 100–500 nm has similar bioavailability to other forms of selenium into plants, animals, humans, and microorganisms. Biologically synthesized SeNP has many biological applications in the field of medical and pharmaceutical research to combat threats to human health. Biogenic SeNPs have anticancer (cytotoxic) activity, antioxidant activity, and antimicrobial activity. Researches are going on with special interest of SeNPs. Conjugation of antibiotics with SeNPs enhances their anticancer efficacy. SeNPs have also applications in nanobiosensors and environmental remediation.

Antioxidant Activity of Coated Probiotic Lactobacillus casei on Chromium(VI) Induced Oxidative Stress in Rats

2013 ◽  
Vol 84 (2) ◽  
pp. 305-310 ◽  
Author(s):  
R. Balakrishnan ◽  
C. S. V. Satish Kumar ◽  
K. Kondal Reddy ◽  
M. Usha Rani ◽  
M. K. Srikanth ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Lactobacillus Casei ◽  
Chromium Vi ◽  
Probiotic Lactobacillus

Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 alleviate diquat-induced intestinal barrier dysfunction in C57BL/6 mice through their antioxidant activity

2020 ◽  
Vol 11 (4) ◽  
pp. 3020-3031 ◽  
Author(s):  
Lei Qiao ◽  
Xina Dou ◽  
Shuqi Yan ◽  
Baohua Zhang ◽  
Chunlan Xu
Keyword(s):  
Antioxidant Activity ◽  
Oxidative Damage ◽  
Signaling Pathway ◽  
Lactobacillus Casei ◽  
Intestinal Barrier ◽  
Selenium Nanoparticles ◽  
Barrier Dysfunction ◽  
Intestinal Barrier Dysfunction ◽  
Nrf2 Signaling Pathway ◽  
Biogenic Selenium Nanoparticles

Biogenic SeNPs synthesized by Lactobacillus casei ATCC 393 reversed diquat-induced oxidative damage to the epithelium by activating the Nrf2 signaling pathway.

scholarly journals Se@SiO2 nanocomposites suppress microglia-mediated reactive oxygen species during spinal cord injury in rats

RSC Advances ◽  
2018 ◽  
Vol 8 (29) ◽  
pp. 16126-16138
Author(s):  
Weiheng Wang ◽  
Xiaodong Huang ◽  
Yongxing Zhang ◽  
Guoying Deng ◽  
Xijian Liu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Antioxidant Activity ◽  
Trace Element ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Essential Trace Element ◽  
Cord Injury ◽  
Sio2 Nanocomposites

Selenium (Se) is an essential trace element with strong antioxidant activity, showing a great prospect in the treatment of spinal cord injury (SCI).

scholarly journals L-Carnitine Reduces Oxidative Stress and Promotes Cells Differentiation and Bone Matrix Proteins Expression in Human Osteoblast-Like Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Ileana Terruzzi ◽  
Anna Montesano ◽  
Pamela Senesi ◽  
Isabella Villa ◽  
Anita Ferraretto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Mitochondrial Dysfunction ◽  
Bone Matrix ◽  
Antioxidant Property ◽  
Osteoblastic Differentiation ◽  
Bone Fragility ◽  
Mitochondrial Activity ◽  
Ros Production ◽  
Gene And Protein Expression

Bone fragility and associated fracture risk are major problems in aging. Oxidative stress and mitochondrial dysfunction play a key role in the development of bone fragility. Mitochondrial dysfunction is closely associated with excessive production of reactive oxygen species (ROS). L-Carnitine (L-C), a fundamental cofactor in lipid metabolism, has an important antioxidant property. Several studies have shown how L-C enhances osteoblastic proliferation and activity. In the current study, we investigated the potential effects of L-C on mitochondrial activity, ROS production, and gene expression involved in osteoblastic differentiation using osteoblast-like cells (hOBs) derived from elderly patients. The effect of 5mM L-C treatment on mitochondrial activity and L-C antioxidant activity was studied by ROS production evaluation and cell-based antioxidant activity assay. The possible effects of L-C on hOBs differentiation were assessed by analyzing gene and protein expression by Real Time PCR and western blotting, respectively. L-C enhanced mitochondrial activity and improved antioxidant defense of hOBs. Furthermore, L-C increased the phosphorylation of Ca2+/calmodulin-dependent protein kinase II. Additionally, L-C induced the phosphorylation of ERK1/2 and AKT and the main kinases involved in osteoblastic differentiation and upregulated the expression of osteogenic related genes, RUNX2, osterix (OSX), bone sialoprotein (BSP), and osteopontin (OPN) as well as OPN protein synthesis, suggesting that L-C exerts a positive modulation of key osteogenic factors. In conclusion, L-C supplementation could represent a possible adjuvant in the treatment of bone fragility, counteracting oxidative phenomena and promoting bone quality maintenance.

scholarly journals Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Takako Yokozawa ◽  
Jeong Sook Noh ◽  
Chan Hum Park
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Green Tea ◽  
Renal Damage ◽  
Large Fraction ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Tea Polyphenol ◽  
Green Tea Polyphenol ◽  
Low Toxicity

Green tea, prepared from the leaves ofCamellia sinensisL., is a beverage that is popular worldwide. Polyphenols in green tea have been receiving much attention as potential compounds for the maintenance of human health due to their varied biological activity and low toxicity. In particular, the contribution of antioxidant activity to the prevention of diseases caused by oxidative stress has been focused upon. Therefore, in this study, we investigated the effects of (−)-epigallocatechin 3-O-gallate and (−)-epigallocatechin 3-O-gallate, which account for a large fraction of the components of green tea polyphenol, on oxidative stress-related renal disease. Our observations suggest that green tea polyphenols have a beneficial effect on pathological states related to oxidative stress of the kidney.

Antioxidant Activity and Protective Effect against Oxidative Stress on Hippocampal HT22 Cells of Tea Seed Oil

2018 ◽  
Vol 24 (1) ◽  
pp. 53-59
Author(s):  
Jong Min Kim ◽  
Seon Kyeong Park ◽  
Jin Yong Kang ◽  
Seong-kyeong Bae ◽  
Ga-Hee Jeong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Protective Effect ◽  
Seed Oil ◽  
Ht22 Cells ◽  
Tea Seed Oil

UJI AKTIVITAS ANTIOKSIDAN FRAKSI N-HEKSAN DAUN AFRIKA (Vernonia amygdalina Del.) DENGAN METODE DPPH

2020 ◽  
Vol 5 (2) ◽  
pp. 250-257
Author(s):  
Nurul Fatimah ◽  
◽  
Reksi Sundu
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Free Radicals ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Hexane Fraction ◽  
Phytochemical Screening ◽  
Vernonia Amygdalina ◽  
Tropical Africa ◽  
Ic50 Value

Free radicals and reactive species are widely believed to contribute to the development of several diseases by causing oxidative stress and eventually oxidative. Vernonia amygdalina (Astereacea) is a small shrub or tree between 1 and 5m high growing throughout tropical Africa. Plants are generally known as bitter leaves is well cultivated and is a general market for merchandise in several countries. The purpose of this study was to determine the antioxidant activity of hexane fraction from ethanol extract od Frican leaves (Vernonia amygdalina Del.). The method used in this study was the DPPH (1,1-Diphenil-2-Picrylhydrazyl) method. The result of phytochemical screening showed that ethanolic extract of African leaves contained a composition of secondary metabolites of alkaloids, flavonoids, tannins, steroids/triterpenoids and saponins. The antioxidant activity of the extract of n-hexane fraction was classified as very weak with an IC50 value of 317.98 ppm.

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