scholarly journals Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Takako Yokozawa ◽  
Jeong Sook Noh ◽  
Chan Hum Park

Green tea, prepared from the leaves ofCamellia sinensisL., is a beverage that is popular worldwide. Polyphenols in green tea have been receiving much attention as potential compounds for the maintenance of human health due to their varied biological activity and low toxicity. In particular, the contribution of antioxidant activity to the prevention of diseases caused by oxidative stress has been focused upon. Therefore, in this study, we investigated the effects of (−)-epigallocatechin 3-O-gallate and (−)-epigallocatechin 3-O-gallate, which account for a large fraction of the components of green tea polyphenol, on oxidative stress-related renal disease. Our observations suggest that green tea polyphenols have a beneficial effect on pathological states related to oxidative stress of the kidney.

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2533
Author(s):  
Rackhyun Park ◽  
Minsu Jang ◽  
Yea-In Park ◽  
Yeonjeong Park ◽  
Woochul Jung ◽  
...  

The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, inhibit coronavirus enzymes as well as coronavirus replication in vitro. Herein, we examined the inhibitory effect of green tea polyphenols on coronavirus replication in a mouse model. We used epigallocatechin gallate (EGCG) and green tea polyphenols containing more than 60% catechin (GTP60) and human coronavirus OC43 (HCoV-OC43) as a surrogate for SARS-CoV-2. Scanning electron microscopy analysis results showed that HCoV-OC43 infection resulted in virion particle production in infected cells. EGCG and GTP60 treatment reduced coronavirus protein and virus production in the cells. Finally, EGCG- and GTP60-fed mice exhibited reduced levels of coronavirus RNA in mouse lungs. These results demonstrate that green tea polyphenol treatment is effective in decreasing the level of coronavirus in vivo.


2020 ◽  
Vol 11 (1) ◽  
pp. 534-543 ◽  
Author(s):  
Jianping Wang ◽  
Ru Jia ◽  
Pietro Celi ◽  
Xuemei Ding ◽  
Shiping Bai ◽  
...  

Dietary supplementation with EGCG led to an increase in egg antioxidant activity and antioxidant chemical substances, tryptophan and carotenoid. This may be associated with its increasing effect on the oxidative stress related regulators expression (P38MAPK, Nrf2 and HO-1).


2005 ◽  
Vol 27 (9) ◽  
pp. 655-660 ◽  
Author(s):  
Dong-Wook Han ◽  
Hak Hee Kim ◽  
Mi Hee Lee ◽  
Hyun Sook Baek ◽  
Kwon-Yong Lee ◽  
...  

Carbon ◽  
2012 ◽  
Vol 50 (8) ◽  
pp. 3015-3025 ◽  
Author(s):  
O. Akhavan ◽  
M. Kalaee ◽  
Z.S. Alavi ◽  
S.M.A. Ghiasi ◽  
A. Esfandiar

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