Dietary niacin affects intestinal morphology and functions via modulating cell proliferation in weaned piglets

2021 ◽  
Author(s):  
Huansheng Yang ◽  
Zhenfeng Yi ◽  
Xian Tan ◽  
Qiye Wang ◽  
Pengfei Huang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Intestinal Morphology ◽  
Intestinal Health ◽  
Weaned Piglets ◽  
Mucous Membranes ◽  
Niacin Deficiency

Niacin deficiency leads to inflammation of mucous membranes and diarrhoea.There are few reports on the effects of niacin on the intestinal health of weaned piglets. The present study was conducted...

scholarly journals Application of FOS and CPP in intestinal health of Weaned Piglets

2019 ◽  
Vol 131 ◽  
pp. 01077
Author(s):  
Feng Zhao ◽  
Zhongsheng Xia
Keyword(s):  
Ph Value ◽  
Intestinal Flora ◽  
Intestinal Morphology ◽  
Control Group ◽  
Female Group ◽  
Intestinal Health ◽  
Weaned Piglets ◽  
Jejunal Segment ◽  
Significant Difference ◽  
Antibiotic Group

The present experiment was conducted to study the effects of different levels of oligosaccharide(FOS) and complex CPP preparation(CPP) in diets on growth performance and serum biochemical parameters for weaned piglets. 240 crossbred DLY( Duroc× Landrace× Yorkshire) 21-day-old weaning piglets, about 7.2 kg in initial body weight were selected and randomly divided into 6 groups, with 2 repeats for each group, 20 each repeat(half male and half female.). Group 1, as the control group, fed base diet(BD) , group 2 fed BD adding 0.10% aureomycin, group 3, 4, 5, 6, respectively, fed BD adding 0.05% CPP, 0.05% FOS, 0.20% FOS and 0.10% FOS + 0.05% of CPP. Feeding trial was conducted for 35 days.Results: (1) Intestinal pH: Compared with the control group, the pH values of jejunum, ileum, cecum and colon in the 3, 4, 5 and 6 groups were significantly lower (P < 0.05), while there was no significant difference between the antibiotic group and the control group (P > 0.05).(2) Small intestinal villus morphology: Duodenal segment, villus length of 6 groups was significantly increased compared with the control group (P < 0.05), villus height to recess depth ratio (V/C) was significantly increased (P < 0.05). There was no significant difference in villus length between groups in jejunal segment (P > 0.05). Groups five V/C was significantly higher than that in the control group (P < 0.05). Compared with the control group and the antibiotic group, the ileal segment in the six groups significantly increased V/C (P < 0.05).(3) Intestinal flora Adding FOS, CPP and their combination could reduce the number of E. coli and Salmonella in different intestinal segments, and increase the number of Lactobacillus and Bifidobacteria. Among them, the effect of joint addition is the most obvious. Conclusion: Adding FOS and C PP to the diet of weaned piglets could effectively reduce the intestinal pH value of piglets, increase the length of intestinal villi and V/C, reduce the number of harmful bacteria and increase the number of beneficial bacteria. It is beneficial to maintain the balance of intestinal morphology and microflora and improve the intestinal health of piglets. Among them, the combination of 0.10% FOS and 0.05% CPP is the best, followed by 0.20% FOS.

scholarly journals Dietary supplementation with Bacillus mixture promotes the gut health of weaned piglets

2019 ◽  
Author(s):  
Xiaodan Wang ◽  
Zhilong Tian ◽  
Yue Zhao ◽  
Wenming Zhang ◽  
Zhanbin Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Dietary Supplementation ◽  
Intestinal Morphology ◽  
Control Group ◽  
Gut Health ◽  
Intestinal Health ◽  
Weaned Piglets ◽  
Villus Height ◽  
Crypt Depth ◽  
Relative Abundances

Abstract This study was conducted to investigate the effects of dietary supplementation with a mixture of Bacillus on the intestinal health of weaned piglets. We randomly assigned 120 piglets to three groups; a control group (basal diet), a probiotics group (supplemented with 4 × 109 CFU/g Bacillus licheniformis-B. subtilis mixture; BLS mix), and an antibiotics group (supplemented with 0.04 kg/t virginiamycin, 0.2 kg/t colistin, and 3000 mg/kg zinc oxide). All groups had five replicates with eight piglets per replicate. On days 7, 21, and 42 of the trial, intestine and digesta samples were collected to determine the intestinal morphology, gut microbiota and metabolites, and the expression of genes related to gut health. The results showed that the BLS mix decreased the jejunum crypt depth, increased the ileum villus height, and increased the jejunum and ileum villus height to crypt depth ratio. The BLS mix also increased the expression levels of E-cadherin and Occludin in the colon and pro-inflammatory cytokines and TLR4 in ileum and colon. The BLS mix also increased Simpson’s diversity index in the gut microbiota and the relative abundances of o_Bacteroidetes and f_Ruminococcaceae, but it decreased the relative abundances of Blautia, and Clostridium. Collectively, these findings suggested that dietary BLS mix supplementation efficaciously promotes intestinal health through the modulation of gut microbiota in weaned piglets.

scholarly journals Wheat bran fermented by mixed fungal strains improves the digestibility of crude fiber and may benefit the gut health without impacting the growth performance in weaned pigs

2021 ◽  
Vol 12 (7) ◽  
pp. 2962-2971
Author(s):  
Yuheng Luo ◽  
Jun He ◽  
Hua Li ◽  
Cong Lan ◽  
Jingyi Cai ◽  
...  
Keyword(s):  
Growth Performance ◽  
Wheat Bran ◽  
Nutrient Digestibility ◽  
Crude Fiber ◽  
Gut Health ◽  
Intestinal Health ◽  
Weaned Piglets ◽  
Weaned Pigs ◽  
Fungal Strains

This study was conducted to compare the effect of raw (WB) or mixed fungi-fermented wheat bran (FWB) on the growth, nutrient digestibility and intestinal health in weaned piglets.

Effects of graded levels of xylo-oligosaccharides on growth performance, serum parameters, intestinal morphology and intestinal barrier function in weaned piglets

2021 ◽  
Author(s):  
Yuxia Chen ◽  
Yining Xie ◽  
Ruqing Zhong ◽  
Hui Han ◽  
Lei Liu ◽  
...  
Keyword(s):  
Growth Performance ◽  
Intestinal Barrier ◽  
Intestinal Morphology ◽  
Intestinal Barrier Function ◽  
Weaned Piglets ◽  
Villus Height ◽  
Expression Levels ◽  
Small Intestinal ◽  
Dietary Treatments ◽  
Mrna Expression Levels

Abstract The objective of this study was to investigate the effects of xylo-oligosaccharides (XOS) supplementation on growth performance, serum parameters, small intestinal morphology, intestinal mucosal integrity, and immune function in weaned piglets. A total of 240 weaned piglets with an average body weight (BW) of 8.82 ± 0.05 kg (28 d of age) were assigned randomly to 4 dietary treatments in a 28-d trial, including a control diet (CON), 3 diets with XOS supplementation at the concentration of 100, 500 and 1000 mg/kg (XOS100, XOS500, and XOS1000). There were 4 replicates per treatment with 15 pigs per pen. From d 1 to 14, there were no differences (P &gt; 0.05) in average daily gain (ADG), average daily feed intake (ADFI), and gain to feed ratio (G:F) during the different treatments. The different doses of XOS showed a quadratic effect on BW on d 28, ADG and G:F d 1-28 of piglets (P &lt; 0.05). From d 15 to 28, ADG of pigs fed the XOS500 diet was higher (P &lt; 0.05) than pigs fed the CON diet. During the overall period (d 1 to 28), pigs fed the XOS500 diet had a higher BW, ADG and G:F than pigs fed the CON diet (P &lt; 0.05). In addition, compared with the CON group, the XOS500 group had significantly higher serum total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD) and catalase (CAT) levels and lower malondialdehyde (MDA) levels on d 14 and 28 (P &lt; 0.05). The serum immunoglobulin G (IgG) concentration in the XOS500 group was also significantly higher compared with the CON group on d 14 and 28 (P &lt;0.05). However, serum immunoglobulin A (IgA) and immunoglobulin M (IgM) were not affected by the dietary treatments. Supplementation of XOS500 to the feed significantly increased the villus height (VH) and villus height to crypt depth ratio (VH:CD) in the jejunum and ileum in comparison with the CON and XOS1000 group. Moreover, the XOS500 group significantly elevated the expression levels of Occludin and zonula occludens protein-1 (ZO-1) in the ileum compared to the CON group. The ileal interleukin (IL)-1β, IL-8 and interferon (IFN)-γ mRNA expression levels in the XOS100 and XOS500 group were markedly lower than in the CON group. In contrast, the ileal IL-10 mRNA expression levels were remarkably higher in the XOS500 than CON group. In conclusion, xylo-oligosaccharides have a beneficial effect on growth performance by improving serum antioxidant defense system, serum IgG, small intestinal structure and intestinal barrier function in weaned piglets.

Dietary xylo-oligosaccharide improves intestinal functions in weaned piglets

2019 ◽  
Vol 10 (5) ◽  
pp. 2701-2709 ◽  
Author(s):  
Jie Yin ◽  
Fengna Li ◽  
Xiangfeng Kong ◽  
Chaoyue Wen ◽  
Qiuping Guo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Tight Junctions ◽  
Intestinal Morphology ◽  
Weaned Piglets ◽  
Intestinal Functions

This study aimed at investigating the effects of dietary xylo-oligosaccharide (XOS) on intestinal functions (i.e., intestinal morphology, tight junctions, gut microbiota and metabolism) and growth performance in weaned piglets.

scholarly journals Dietary Supplementation with Trihexanoin Enhances Intestinal Function of Weaned Piglets

2018 ◽  
Vol 19 (10) ◽  
pp. 3277
Author(s):  
Tao Wu ◽  
Kang Li ◽  
Dan Yi ◽  
Lei Wang ◽  
Di Zhao ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Fat Metabolism ◽  
Dietary Supplementation ◽  
Basal Diet ◽  
Intestinal Morphology ◽  
Mucosal Barrier ◽  
Mrna Levels ◽  
Intestinal Function ◽  
Weaned Piglets ◽  
And Function

Trihexanoin is a short-chain triglyceride (SCT). Many studies have reported that SCTs play important roles in the maintenance of intestinal epithelial structure and function. The present work was to investigate the effects of trihexanoin on growth performance, carbohydrate and fat metabolism, as well as intestinal morphology and function in weaned piglets. Twenty weaned piglets (21 ± 2 d) were randomly allocated to one of two treatment groups: The control group (basal diet supplemented with 0.5% soya oil); the TH group (basal diet supplemented with 0.5% trihexanoin). Dietary trihexanoin supplementation significantly reduced diarrhea rate; increased the concentrations of LDL, HDL and total protein in plasma; decreased cholesterol concentrations and glutamyl transpeptidase activity in plasma; improved intestinal morphologic structure; altered the mRNA levels and abundances of proteins related to glycogen and fat metabolism, mucosal barrier function, antioxidant capacity and water transport capacity; and altered the community of intestinal microflora. These results indicate that dietary trihexanoin supplementation could reduce diarrhea, regulate carbohydrate and fat metabolism, exert beneficial effects on the intestinal mucosal barrier, protect the intestinal mucosa from injuries, improve intestinal transport and absorption, and enhance antioxidant capacity. In conclusion, dietary supplementation with 0.5% trihexanoin improves the intestinal function and health of weaned piglets.

scholarly journals PSVIII-18 Dietary supplementation with trihexanoin enhances intestinal function of weaned piglets

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 302-303
Author(s):  
Tao Wu
Keyword(s):  
Fat Metabolism ◽  
Dietary Supplementation ◽  
Basal Diet ◽  
Intestinal Morphology ◽  
Mucosal Barrier ◽  
Mrna Levels ◽  
Intestinal Function ◽  
Weaned Piglets ◽  
Villus Height ◽  
And Function

Abstract Trihexanoin is a short-chain triglyceride (SCT). Many studies have reported that SCTs play important roles in the maintenance of intestinal epithelial structure and function. The present work was to investigate the effects of trihexanoin on growth performance, carbohydrate and fat metabolism, as well as intestinal morphology and function in weaned piglets. Twenty weaned piglets (21 ± 2 d) were randomly allocated to one of two treatment groups: the control group (basal diet supplemented with 0.5% soya oil); the TH group (basal diet supplemented with 0.5% trihexanoin). Dietary trihexanoin supplementation significantly reduced diarrhea rate (P &lt; 0.05); increased the concentrations of LDL, HDL and total protein, decreased cholesterol concentrations (CHOL) and glutamyl transpeptidase (GGT) activity in plasma (P &lt; 0.05); increased villus height, surface area, and the ratio of villus height to crypt depth (P &lt; 0.05); altered the mRNA levels and abundances of proteins related to glycogen and fat metabolism (gene LIPE, LPL, PPARG, ACACA, FASN, SLC27A2, INSR, PCK1 and ASS1), mucosal barrier function (protein claudin-1, and occludin), antioxidant capacity (protein HSP70 and gene Nrf2, NOX2 and GSTO2) and water transport capacity (protein AQP3 and gene AQP8 and AQP10) (P &lt; 0.05); altered the gene abundance of intestinal bacteria (Enterobacteriaceae, Enterococcus, Clostridium, Lactobacillus and Bifidobacterium) (P &lt; 0.05). In conclusion, dietary supplementation of trihexanoin improved the intestinal function and health of weaned piglets by regulating nutrient metabolism, improving intestinal function of mucosal barrier, transport, absorption and antioxidant, and altering the community of microbiota.

Sign in / Sign up

Export Citation Format

Share Document