Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid

2021 ◽  
Author(s):  
Yuanyuan Di ◽  
Zhongqi Li ◽  
Jin Li ◽  
Qiangqiang Cheng ◽  
Qi Zheng ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Folic Acid ◽  
Rat Model ◽  
Folic Acid Supplementation ◽  
Autism Spectrum ◽  
Vitamin Supplementation ◽  
Maternal Vitamin ◽  
High Prevalence ◽  
Autistic Behaviors

Maternal vitamin supplementation has been demonstrated to reduce risks of a number of neurodevelopmental diseases in children. Autism spectrum disorder (ASD) is a group of neurodevelopment defects with high prevalence...

Neurobiological substrates underlying corpus callosum hypoconnectivity and brain metabolic patterns in the valproic acid rat model of autism spectrum disorder

2021 ◽  
Author(s):  
Nonthué Alejandra Uccelli ◽  
Martín Gabriel Codagnone ◽  
Marianela Evelyn Traetta ◽  
Nadia Levanovich ◽  
María Victoria Rosato Siri ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Corpus Callosum ◽  
Rat Model ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Neurobiological Substrates

Cariprazine Alleviates Core Behavioral Deficits in the Prenatal Valproic Acid Exposure Rat Model of Autism Spectrum Disorder

2020 ◽  
Vol 87 (9) ◽  
pp. S148-S149
Author(s):  
Nika Adham ◽  
Andrew Foley ◽  
Lynsey Hanratty ◽  
Béla Kiss ◽  
Bence Farkas ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Rat Model ◽  
Autism Spectrum ◽  
Acid Exposure ◽  
Spectrum Disorder ◽  
Behavioral Deficits

scholarly journals Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder

2017 ◽  
Vol 11 (1) ◽  
pp. 69-80 ◽  
Author(s):  
Amanda J. Goodrich ◽  
Heather E. Volk ◽  
Daniel J. Tancredi ◽  
Rob McConnell ◽  
Fred W. Lurmann ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Autism Spectrum ◽  
Air Pollutant ◽  
Spectrum Disorder ◽  
Acid Supplementation ◽  
Joint Effects

scholarly journals Preliminary Results Regarding Sleep in a Zebrafish Model of Autism Spectrum Disorder

2021 ◽  
Vol 11 (5) ◽  
pp. 556
Author(s):  
Madalina Andreea Robea ◽  
Alin Ciobica ◽  
Alexandrina-Stefania Curpan ◽  
Gabriel Plavan ◽  
Stefan Strungaru ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Social Behavior ◽  
Antiepileptic Drug ◽  
Alternative Model ◽  
Neurological Diseases ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Zebrafish Model ◽  
Developmental Defects

Autism spectrum disorder (ASD) is one of the most salient developmental neurological diseases and remarkable similarities have been found between humans and model animals of ASD. A common method of inducing ASD in zebrafish is by administrating valproic acid (VPA), which is an antiepileptic drug that is strongly linked with developmental defects in children. In the present study we replicated and extended the findings of VPA on social behavior in zebrafish by adding several sleep observations. Juvenile zebrafish manifested hyperactivity and an increase in ASD-like social behaviors but, interestingly, only exhibited minimal alterations in sleep. Our study confirmed that VPA can generate specific ASD symptoms, indicating that the zebrafish is an alternative model in this field of research.

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