Flavonoid-rich extracts from okra flowers exert antitumor activity in colorectal cancer through induction of mitochondrial dysfunction-associated apoptosis, senescence and autophagy

2020 ◽  
Vol 11 (12) ◽  
pp. 10448-10466
Author(s):  
Yuanle Deng ◽  
Sha Li ◽  
Meng Wang ◽  
Xiaotong Chen ◽  
Li Tian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Mitochondrial Dysfunction

AFE activates p53, acting on apoptosis, autophagy, senescence, and metastasis, and induces mitochondrial dysfunction.

scholarly journals Colorectal Cancer Apoptosis Induced by Dietary δ-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3

2021 ◽  
Vol 22 (15) ◽  
pp. 8117
Author(s):  
Nunzia D’Onofrio ◽  
Elisa Martino ◽  
Luigi Mele ◽  
Antonino Colloca ◽  
Martina Maione ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Current Knowledge ◽  
Apoptotic Cell ◽  
Critical Role ◽  
Dependent Manner ◽  
Colon Cancer Cells ◽  
Protein Levels

Understanding the mechanisms of colorectal cancer progression is crucial in the setting of strategies for its prevention. δ-Valerobetaine (δVB) is an emerging dietary metabolite showing cytotoxic activity in colon cancer cells via autophagy and apoptosis. Here, we aimed to deepen current knowledge on the mechanism of δVB-induced colon cancer cell death by investigating the apoptotic cascade in colorectal adenocarcinoma SW480 and SW620 cells and evaluating the molecular players of mitochondrial dysfunction. Results indicated that δVB reduced cell viability in a time-dependent manner, reaching IC50 after 72 h of incubation with δVB 1.5 mM, and caused a G2/M cell cycle arrest with upregulation of cyclin A and cyclin B protein levels. The increased apoptotic cell rate occurred via caspase-3 activation with a concomitant loss in mitochondrial membrane potential and SIRT3 downregulation. Functional studies indicated that δVB activated mitochondrial apoptosis through PINK1/Parkin pathways, as upregulation of PINK1, Parkin, and LC3B protein levels was observed (p < 0.0001). Together, these findings support a critical role of PINK1/Parkin-mediated mitophagy in mitochondrial dysfunction and apoptosis induced by δVB in SW480 and SW620 colon cancer cells.

Antitumor activity in colorectal cancer induced by hinokiflavone

2019 ◽  
Vol 34 (9) ◽  
pp. 1571-1580
Author(s):  
Jing Zhou ◽  
Rongce Zhao ◽  
Tinghong Ye ◽  
Shuping Yang ◽  
Yali Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity

scholarly journals Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Peter J. Klauck ◽  
Stacey M. Bagby ◽  
Anna Capasso ◽  
Erica L. Bradshaw-Pierce ◽  
Heather M. Selby ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Kinase Inhibitor ◽  
Preclinical Models

scholarly journals Radix Tetrastigma hemsleyani flavone exhibits antitumor activity in colorectal cancer via Wnt/β-catenin signaling pathway

2018 ◽  
Vol Volume 11 ◽  
pp. 6437-6446 ◽  
Author(s):  
Xiaowei Wu ◽  
Na Yu ◽  
Yuping Zhang ◽  
Yuanning Ye ◽  
Wenrong Sun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Signaling Pathway ◽  
Beta Catenin

FS222, a CD137/PD-L1 Tetravalent Bispecific Antibody, Exhibits Low Toxicity and Antitumor Activity in Colorectal Cancer Models

2020 ◽  
Vol 26 (15) ◽  
pp. 4154-4167 ◽  
Author(s):  
Matthew A. Lakins ◽  
Alexander Koers ◽  
Raffaella Giambalvo ◽  
Jose Munoz-Olaya ◽  
Robert Hughes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Bispecific Antibody ◽  
Cancer Models ◽  
Low Toxicity
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