Dietary riboflavin deficiency induces genomic instability of esophageal squamous cells that is associated with gut microbiota dysbiosis in rats

2020 ◽  
Vol 11 (11) ◽  
pp. 10070-10083 ◽  
Author(s):  
Feng Pan ◽  
Xin Xu ◽  
Ling-Li Zhang ◽  
Hong-Jun Luo ◽  
Ye Chen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Genomic Instability ◽  
Riboflavin Deficiency ◽  
Squamous Cells ◽  
Gut Microbiota Dysbiosis ◽  
Xenobiotic Biodegradation

Dietary riboflavin deficiency promotes carcinogen NMBA-induced esophageal tumorigenesis and is associated with gut microbiota dysbiosis in rats. Reduction of xenobiotic biodegradation and genomic instability may be the involved potential mechanisms.

scholarly journals Correction: Dietary riboflavin deficiency induces genomic instability of esophageal squamous cells that is associated with gut microbiota dysbiosis in rats

2020 ◽  
Vol 11 (12) ◽  
pp. 10979-10979
Author(s):  
Feng Pan ◽  
Xin Xu ◽  
Ling-Li Zhang ◽  
Hong-Jun Luo ◽  
Ye Chen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Genomic Instability ◽  
Riboflavin Deficiency ◽  
Squamous Cells ◽  
Gut Microbiota Dysbiosis

Correction for ‘Dietary riboflavin deficiency induces genomic instability of esophageal squamous cells that is associated with gut microbiota dysbiosis in rats’ by Feng Pan et al., Food Funct., 2020, DOI: 10.1039/d0fo01944e.

scholarly journals Dietary switch to Western diet induces hypothalamic adaptation associated with gut microbiota dysbiosis in rats

2021 ◽  
Author(s):  
Mélanie Fouesnard ◽  
Johanna Zoppi ◽  
Mélanie Petera ◽  
Léa Le Gleau ◽  
Carole Migné ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Western Diet ◽  
Dietary Switch ◽  
Gut Microbiota Dysbiosis

scholarly journals Constipation induced gut microbiota dysbiosis exacerbates experimental autoimmune encephalomyelitis in C57BL/6 mice

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiuli Lin ◽  
Yingying Liu ◽  
Lili Ma ◽  
Xiaomeng Ma ◽  
Liping Shen ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Gut Microbiota ◽  
Blood Brain Barrier ◽  
Intestinal Barrier ◽  
Brain Barrier ◽  
Autoimmune Encephalomyelitis ◽  
Gm Csf ◽  
Blood Brain ◽  
Gut Microbiota Dysbiosis ◽  
Experimental Autoimmune

Abstract Background Constipation is a common gastrointestinal dysfunction which has a potential impact on people's immune state and their quality of life. Here we investigated the effects of constipation on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Methods Constipation was induced by loperamide in female C57BL/6 mice. The alternations of gut microbiota, permeability of intestinal barrier and blood–brain barrier, and histopathology of colon were assessed after constipation induction. EAE was induced in the constipation mice. Fecal microbiota transplantation (FMT) was performed from constipation mice into microbiota-depleted mice. Clinical scores, histopathology of inflammation and demyelination, Treg/Th17 and Treg17/Teff17 imbalance both in the peripheral lymphatic organs and central nervous system, cytokines include TGF-β, GM-CSF, IL-10, IL-17A, IL-17F, IL-21, IL-22, and IL-23 in serum were assessed in different groups. Results Compared with the vehicle group, the constipation mice showed gut microbiota dysbiosis, colon inflammation and injury, and increased permeability of intestinal barrier and blood–brain barrier. We found that the clinical and pathological scores of the constipation EAE mice were severer than that of the EAE mice. Compared with the EAE mice, the constipation EAE mice showed reduced percentage of Treg and Treg17 cells, increased percentage of Th17 and Teff17 cells, and decreased ratio of Treg/Th17 and Treg17/Teff17 in the spleen, inguinal lymph nodes, brain, and spinal cord. Moreover, the serum levels of TGF-β, IL-10, and IL-21 were decreased while the GM-CSF, IL-17A, IL-17F, IL-22, and IL-23 were increased in the constipation EAE mice. In addition, these pathological processes could be transferred via their gut microbiota. Conclusions Our results verified that constipation induced gut microbiota dysbiosis exacerbated EAE via aggravating Treg/Th17 and Treg17/Teff17 imbalance and cytokines disturbance in C57BL/6 mice.

Evidence from comparative genomic analyses indicating that Lactobacillus-mediated irritable bowel syndrome alleviation is mediated by the conjugated linoleic acid synthesis

2021 ◽  
Author(s):  
Yang Liu ◽  
Wei Xiao ◽  
Leilei Yu ◽  
Fengwei Tian ◽  
Gang Wang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Linoleic Acid ◽  
Gut Microbiota ◽  
Acid Synthesis ◽  
Comparative Genomic ◽  
Low Grade ◽  
Genomic Analyses ◽  
Irritable Bowel ◽  
Low Grade Inflammation ◽  
Gut Microbiota Dysbiosis

Irritable bowel syndrome (IBS) is a chronic intestinal disorder accompanied by low-grade inflammation, visceral hypersensitivity, and gut microbiota dysbiosis. Several studies have indicated that Lactobacillus supplementation can help to alleviate...

Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice

BioFactors ◽  
2018 ◽  
Vol 45 (2) ◽  
pp. 187-199 ◽  
Author(s):  
Zheng Xu ◽  
Can Wang ◽  
Xiaoguang Dong ◽  
Tao Hu ◽  
Lingling Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Alcohol Exposure ◽  
Chronic Alcohol ◽  
Chronic Alcohol Exposure ◽  
Gut Microbiota Dysbiosis

scholarly journals Iron deficiency anemia-related gut microbiota dysbiosis in infants and young children: A pilot study

2018 ◽  
Vol 65 (4) ◽  
pp. 551-564 ◽  
Author(s):  
Audrone Muleviciene ◽  
Federica D’Amico ◽  
Silvia Turroni ◽  
Marco Candela ◽  
Augustina Jankauskiene
Keyword(s):  
Pilot Study ◽  
Iron Deficiency ◽  
Young Children ◽  
Gut Microbiota ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Gut Microbiota Dysbiosis ◽  
Infants And Young Children
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