Sacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats

2020 ◽  
Vol 11 (7) ◽  
pp. 5827-5841
Author(s):  
Pan Li ◽  
Jianzhao Huang ◽  
Nan Xiao ◽  
Xin Cai ◽  
Yunyun Yang ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Lipid ◽  
Sacha Inchi Oil ◽  
Sacha Inchi ◽  
Gut Microbiota Dysbiosis

We report that sacha inchi oil with plant-derived ω-3 PUFAs alleviates gut microbiota dysbiosis, prevents bile acid dysmetabolism, and ameliorates hepatic lipid dysmetabolism of glycerolipids, glycerophospholipids, and sphingolipids in HFD rats.

Grifola frondosapolysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats

2019 ◽  
Vol 10 (5) ◽  
pp. 2560-2572 ◽  
Author(s):  
Lu Li ◽  
Wei-Ling Guo ◽  
Wen Zhang ◽  
Jia-Xin Xu ◽  
Min Qian ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Cholesterol Metabolism ◽  
High Fat ◽  
Hepatic Lipid ◽  
Expression Of Genes ◽  
Gut Microbiota Dysbiosis

G. frondosapolysaccharides have the potential to ameliorate lipid metabolic disorders in part through modulating gut microbiota and mRNA expression of genes involved in hepatic lipid and cholesterol metabolism.

Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet

2021 ◽  
Author(s):  
Yilin Liu ◽  
Chunyan Xie ◽  
Zhenya Zhai ◽  
Ze-yuan Deng ◽  
Hugo R. De Jonge ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Fat Accumulation ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Gut Microbiota Composition

This study aimed to investigate the effect of uridine on obesity, fat accumulation in liver, and gut microbiota composition in high-fat diet-fed mice.

Yeast β-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models

2021 ◽  
Author(s):  
Sik Yu So ◽  
Qinglong Wu ◽  
Kin Sum Leung ◽  
Zuzanna Maria Kundi ◽  
Tor C Savidge ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Health ◽  
Metabolic Phenotype ◽  
Bile Acid Metabolism ◽  
Microbiota Composition ◽  
High Fat ◽  
Mrna Accumulation ◽  
Gut Microbiota Composition

Emerging evidence links dietary fiber with altered gut microbiota composition and bile acid signaling in maintaining metabolic health. Yeast β-glucan (Y-BG) is a dietary supplement known for its immunomodulatory effect, yet its impact on the gut microbiota and bile acid composition remains unclear. This study investigated whether dietary forms of Y-BG modulate these gut-derived signals. We performed 4-week dietary supplementation in healthy mice to evaluate effects of different fiber composition (soluble vs particulate Y-BG) and dose (0.1 vs. 2%). We found that 2% particulate Y-BG induced robust gut microbiota community shifts with elevated liver Cyp7a1 mRNA abundance and bile acid synthesis. These diet-induced responses were notably different when compared to the prebiotic inulin, and included a marked reduction in fecal Bilophila abundance which we demonstrated as translatable to obesity in population-scale American Gut and TwinsUK clinical cohorts. This prompted us to test whether 2% Y-BG maintained metabolic health in mice fed 60% HFD over 13 weeks. Y-BG consistently altered the gut microbiota composition and reduced Bilophila abundance, with trends observed in improvement of metabolic phenotype. Notably, Y-BG improved insulin sensitization and this was associated with enhanced ileal Glpr1r mRNA accumulation and reduced Bilophila abundance. Collectively, our results demonstrate that Y-BG modulates gut microbiota community composition and bile acid signaling, but the dietary regime needs to be optimized to facilitate clinical improvement in metabolic phenotype in an aggressive high-fat diet animal model.

scholarly journals Steatosis and gut microbiota dysbiosis induced by high-fat diet are reversed by 1-week chow diet administration

2019 ◽  
Vol 71 ◽  
pp. 72-88 ◽  
Author(s):  
Zahra Safari ◽  
Magali Monnoye ◽  
Peter M. Abuja ◽  
Mahendra Mariadassou ◽  
Karl Kashofer ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Chow Diet ◽  
High Fat ◽  
Gut Microbiota Dysbiosis

Effects of high-fat diet-induced gut microbiota dysbiosis: far beyond the gut

Gut ◽  
2020 ◽  
Vol 69 (12) ◽  
pp. 2259.1-2259 ◽  
Author(s):  
Tianyu Liu ◽  
Bangmao Wang ◽  
Hailong Cao
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
High Fat ◽  
Gut Microbiota Dysbiosis

A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviates gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice

2018 ◽  
Vol 9 (10) ◽  
pp. 5371-5380 ◽  
Author(s):  
Shan Li ◽  
Junhui Li ◽  
Guizhu Mao ◽  
Tiantian Wu ◽  
Yaqin Hu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Sea Cucumber ◽  
Major Contributor ◽  
High Fat ◽  
Repeated Structure ◽  
Gut Microbiota Dysbiosis ◽  
Metabolic Syndromes

A high-fat diet (HFD) has been a major contributor to increasing morbidity caused by metabolic syndromes.

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