Grifola frondosapolysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats

2019 ◽  
Vol 10 (5) ◽  
pp. 2560-2572 ◽  
Author(s):  
Lu Li ◽  
Wei-Ling Guo ◽  
Wen Zhang ◽  
Jia-Xin Xu ◽  
Min Qian ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Cholesterol Metabolism ◽  
High Fat ◽  
Hepatic Lipid ◽  
Expression Of Genes ◽  
Gut Microbiota Dysbiosis

G. frondosapolysaccharides have the potential to ameliorate lipid metabolic disorders in part through modulating gut microbiota and mRNA expression of genes involved in hepatic lipid and cholesterol metabolism.

Monascus yellow, red and orange pigments from red yeast rice ameliorate lipid metabolic disorders and gut microbiota dysbiosis in Wistar rats fed on a high-fat diet

2019 ◽  
Vol 10 (2) ◽  
pp. 1073-1084 ◽  
Author(s):  
Wenbin Zhou ◽  
Rui Guo ◽  
Weiling Guo ◽  
Jiali Hong ◽  
Lu Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Metabolic Disorders ◽  
Cholesterol Metabolism ◽  
Red Yeast Rice ◽  
High Fat ◽  
Red Yeast ◽  
Gut Microbiota Dysbiosis

Monascus yellow, red and orange pigments modulate specific gut microbial phylotypes and regulating mRNA expression involved in glucose, lipid and cholesterol metabolism.

Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats

2018 ◽  
Vol 9 (6) ◽  
pp. 3419-3431 ◽  
Author(s):  
Wei-Ling Guo ◽  
Yu-Yang Pan ◽  
Lu Li ◽  
Tian-Tian Li ◽  
Bin Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Ganoderma Lucidum ◽  
Metabolic Disorders ◽  
Ethanol Extract ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition ◽  
Mrna Expression Levels

Ethanol extract from Ganoderma lucidum (GL95), enriched with triterpenoids, has the potential to ameliorate lipid metabolic disorders, in part through modulating specific gut microbiota and regulating the mRNA expression levels of the genes involved in lipid and cholesterol.

Sarcodon aspratus polysaccharides ameliorated obesity-induced metabolic disorders and modulated gut microbiota dysbiosis in mice fed a high-fat diet

2020 ◽  
Vol 11 (3) ◽  
pp. 2588-2602 ◽  
Author(s):  
Juan Chen ◽  
Jiaojiao Liu ◽  
Chenchen Yan ◽  
Chan Zhang ◽  
Wenjuan Pan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Fruit Body ◽  
High Fat ◽  
Potential Health ◽  
Gut Microbiota Dysbiosis

The polysaccharides isolated from the fruit body of S. aspratus (SATPs) might be a potential health supplement or prebiotic in the prevention of obesity and associated metabolic disorders.

Sacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats

2020 ◽  
Vol 11 (7) ◽  
pp. 5827-5841
Author(s):  
Pan Li ◽  
Jianzhao Huang ◽  
Nan Xiao ◽  
Xin Cai ◽  
Yunyun Yang ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Lipid ◽  
Sacha Inchi Oil ◽  
Sacha Inchi ◽  
Gut Microbiota Dysbiosis

We report that sacha inchi oil with plant-derived ω-3 PUFAs alleviates gut microbiota dysbiosis, prevents bile acid dysmetabolism, and ameliorates hepatic lipid dysmetabolism of glycerolipids, glycerophospholipids, and sphingolipids in HFD rats.

Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet

2021 ◽  
Author(s):  
Yilin Liu ◽  
Chunyan Xie ◽  
Zhenya Zhai ◽  
Ze-yuan Deng ◽  
Hugo R. De Jonge ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Fat Accumulation ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Gut Microbiota Composition

This study aimed to investigate the effect of uridine on obesity, fat accumulation in liver, and gut microbiota composition in high-fat diet-fed mice.

DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance on SD rats with a high-fat diet

2021 ◽  
Author(s):  
Xiaodan Lu ◽  
Rongbin Zhong ◽  
Ling Hu ◽  
Luyao Huang ◽  
Lijiao Chen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
High Fat Diet ◽  
Nutritional Value ◽  
Metabolic Disorders ◽  
Large Yellow Croaker ◽  
High Fat ◽  
Sd Rats

Abstract Large yellow croaker roe phospholipids (LYCRPLs) has great nutritional value because of containing rich docosahexaenoic acid (DHA), which is a kind of n-3 polyunsaturated fatty acids (n-3 PUFAs). In...

scholarly journals Steatosis and gut microbiota dysbiosis induced by high-fat diet are reversed by 1-week chow diet administration

2019 ◽  
Vol 71 ◽  
pp. 72-88 ◽  
Author(s):  
Zahra Safari ◽  
Magali Monnoye ◽  
Peter M. Abuja ◽  
Mahendra Mariadassou ◽  
Karl Kashofer ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Chow Diet ◽  
High Fat ◽  
Gut Microbiota Dysbiosis

Dietary wood pulp-derived sterols modulation of cholesterol metabolism and gut microbiota in high-fat-diet-fed hamsters

2019 ◽  
Vol 10 (2) ◽  
pp. 775-785 ◽  
Author(s):  
Xiang Li ◽  
Huali Wang ◽  
Tianxin Wang ◽  
Fuping Zheng ◽  
Hao Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorder ◽  
Cholesterol Metabolism ◽  
Wood Pulp ◽  
Microbiota Composition ◽  
High Fat ◽  
Fecal Sterols ◽  
Gut Microbiota Composition

Wood pulp-derived sterols (WS) supplementation ameliorated HFD-associated metabolic disorder; WS supplementation increased the amounts of fecal sterols excretion and SCFAs content; WS supplementation modulated gut microbiota composition.

scholarly journals Effects of gut microbiota on leptin expression and body weight are lessened by high-fat diet in mice

2020 ◽  
Vol 124 (4) ◽  
pp. 396-406 ◽  
Author(s):  
Hongyang Yao ◽  
Chaonan Fan ◽  
Xiuqin Fan ◽  
Yuanyuan Lu ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Body Weight ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
High Fat ◽  
Hepatic Expression ◽  
Reduced Body ◽  
Expression Of Genes ◽  
Underlying Mechanisms ◽  
Leptin Expression

AbstractAberration in leptin expression is one of the most frequent features in the onset and progression of obesity, but the underlying mechanisms are still unclear and need to be clarified. This study investigated the effects of the absence of gut microbiota on body weight and the expression and promoter methylation of the leptin. Male C57 BL/6 J germ-free (GF) and conventional (CV) mice (aged 4–5 weeks) were fed either a normal-fat diet (NFD) or a high-fat diet (HFD) for 16 weeks. Six to eight mice from each group, at 15 weeks, were administered exogenous leptin for 7 d. Leptin expression and body weight gain in GF mice were increased by NFD with more CpG sites hypermethylated at the leptin promoter, whereas there was no change with HFD, compared with CV mice. Adipose or hepatic expression of genes associated with fat synthesis (Acc1, Fas and Srebp-1c), hydrolysis and oxidation (Atgl, Cpt1a, Cpt1c, Ppar-α and Pgc-1α) was lower, and hypothalamus expression of Pomc and Socs3 was higher in GF mice than levels in CV mice, particularly with NFD feeding. Exogenous leptin reduced body weight in both types of mice, with a greater effect on CV mice with NFD. Adipose Lep-R expression was up-regulated, and hepatic Fas and hypothalamic Socs3 were down-regulated in both types of mice. Expression of fat hydrolysis and oxidative genes (Atgl, Hsl, Cpt1a, Cpt1c, Ppar-α and Pgc-1α) was up-regulated in CV mice. Therefore, the effects of gut microbiota on the leptin expression and body weight were affected by dietary fat intake.

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