Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties

2020 ◽  
Vol 11 (7) ◽  
pp. 6608-6621
Author(s):  
Esmaeil Amraie ◽  
Iran Pouraboli ◽  
Ziba Rajaei
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Antioxidant Properties ◽  
Spatial Learning And Memory ◽  
Neuroprotective Effects ◽  
Memory Impairments ◽  
Anti Inflammatory

Levisticum officinale (Apiaceae) has been identified as a medicinal plant in traditional medicine, with the anti-inflammatory, antioxidant, and anticholinesterase activities.

The effects of soy on scopolamine-induced spatial learning and memory impairments are comparable to the effects of estradiol

2019 ◽  
Vol 39 (3) ◽  
Author(s):  
Narges Marefati ◽  
Amin Mokhtari-Zaer ◽  
Farimah Beheshti ◽  
Sareh Karimi ◽  
Zahra Mahdian ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Serum Levels ◽  
Ovariectomized Rats ◽  
Control Group ◽  
Spatial Learning And Memory ◽  
Protective Effects ◽  
Memory Impairments ◽  
The Central Nervous System ◽  
Higher Doses

Abstract Background Modulatory effects of soy extract and estradiol on the central nervous system (CNS) have been reported. The effect of soy on scopolamine-induced spatial learning and memory in comparison to the effect of estradiol was investigated. Materials and methods Ovariectomized rats were divided into the following groups: (1) control, (2) scopolamine (Sco), (3) scopolamine-soy 20 (Sco-S 20), (4) scopolamine-soy 60 (Sco-S 60), (5) scopolamine-estradiol 20 (Sco-E 20) and (6) scopolamine-estradiol 60 (Sco-E 60). Soy extract, estradiol and vehicle were administered daily for 6 weeks before training in the Morris water maze (MWM) test. Scopolamine (2 mg/kg) was injected 30 min before training in the MWM test. Results In the MWM, the escape latency and traveled path to find the platform in the Sco group was prolonged compared to the control group (p < 0.001). Treatment by higher doses of soy improved performances of the rats in the MWM (p < 0.05 – p < 0.001). However, treatment with both doses of estradiol (20 and 60 μg/kg) resulted in a statistically significant improvement in the MWM (p < 0.01 – p < 0.001). Cortical, hippocampal and serum levels of malondialdehyde (MDA), as an index of lipid peroxidation, were increased which was prevented by soy extract and estradiol (p < 0.001). Cortical, hippocampal as well as serum levels of the total thiol, superoxide dismutase (SOD) and catalase (CAT) in Sco group were lower than the control group (p < 0.001) while they were enhanced when the animals were treated by soy extract and estradiol (p < 0.01 – p < 0.001). Conclusions It was observed that both soy extract and estradiol prevented learning and memory impairments induced by scopolamine in ovariectomized rats. These effects can be attributed to their protective effects on oxidative damage of the brain tissue.

scholarly journals Neonatal inhibition of Na + -K + -2Cl − -cotransporter prevents ketamine induced spatial learning and memory impairments

2017 ◽  
Vol 60 ◽  
pp. 82-86 ◽  
Author(s):  
Ryan A. Stevens ◽  
Brandon D. Butler ◽  
Saurabh S. Kokane ◽  
Andrew W. Womack ◽  
Qing Lin
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory ◽  
Memory Impairments

Evaluating the effects of single and combined chelators therapies on spatial learning and memory impairments in chronic manganese poisoning

Toxin Reviews ◽  
2016 ◽  
Vol 35 (1-2) ◽  
pp. 38-46
Author(s):  
Tayyebeh Zandevakili ◽  
S. Jamilalddin Fatemi ◽  
Mohammad Shabani ◽  
Khadije Esmaeilpour ◽  
Vahid Sheibani
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory ◽  
Memory Impairments ◽  
Manganese Poisoning
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