Evaluation of the relationship between the peptide profiles and the lipid-lowering properties of olive seed hydrolysates as a tool for tuning hypocholesterolemic functionality

2020 ◽  
Vol 11 (6) ◽  
pp. 4973-4981
Author(s):  
Isabel M. Prados ◽  
Merichel Plaza ◽  
M. Luisa Marina ◽  
M. Concepción García
Keyword(s):  
High Protein ◽  
Lipid Lowering ◽  
Olive Seed ◽  
Peptide Profiles ◽  
The Relationship

Olive processing generates large amounts of stones with high protein contents.

Abstract 6277: Predictive Value of Estimated Glomerular Filtration Rate for Cardiovascular Events: The Treating to New Targets Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
James Shepherd ◽  
Chuan-Chuan Wun ◽  
Daniel J Wilson ◽  
Andrea L Zuckerman
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cardiovascular Events ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Lipid Lowering ◽  
Final Visit ◽  
The Relationship ◽  
Dose Dependent

We previously demonstrated a dose-dependent improvement in renal function and reduction in cardiovascular risk in TNT with intensive lipid lowering with atorvastatin (ATV) 80 mg vs 10 mg. This post hoc analysis examines the relationship between the observed improvement in estimated glomerular filtration rate (eGFR) and reduction of major cardiovascular events (MCVE). After 8 weeks open-label therapy with ATV 10 mg, 10,001 patients with CHD were randomized to double-blind therapy with either ATV 10 or 80 mg. Patients were followed for a median of 4.9 years for the occurrence of MCVEs (CHD death, nonfatal MI, and stroke). The relationship between change from baseline eGFR (using the MDRD equation) at the final visit prior to a MCVE and the risk of MCVE was assessed using a Cox proportional hazards model adjusting for baseline eGFR and other baseline characteristics. Of 9656 patients with complete renal data, 156 had a MCVE before follow-up eGFR assessment and were excluded. In the remaining 9500 patients, mean baseline eGFR was 65.3 mL/min/1.73 m 2 and mean change from baseline was 4.3 mL/min/1.73 m 2 . This represented a reduction in the risk of MCVE of 2.7% per mL increase in eGFR (HR 0.973, 95% CI 0.967– 0.980, P <0.0001). This association remained significant in patients with eGFR <60 and those with eGFR ≥60 mL/min/1.73 m 2 at baseline, with no significant interaction between eGFR change and baseline renal status ( P =0.98). A 5 mL/min on-treatment improvement in eGFR was associated with a 12.6% reduction in MCVE, while a 5 mL/min reduction was associated with a 14.4% increase in MCVE. Mean change from baseline eGFR was 3.5 mL/min/1.73 m 2 with ATV 10 mg and 5.2 mL/min/1.73 m 2 with ATV 80 mg, representing significant 9.3% and 12.4% reductions in risk, respectively. Analysis of interaction between treatment and eGFR change for prediction of MCVE demonstrated a stronger association between eGFR change and MCVE in the ATV 80 mg treatment group ( P =0.011). Improvement in eGFR was highly associated with a reduction in MCVE, irrespective of baseline renal function. This relationship was dose dependent. Improvement in eGFR may be a biomarker for the response to atorvastatin, and for the stabilization of atherosclerotic cardiovascular disease.

Abstract 5108: Microalbuminuria is Associated with Progression of Coronary Atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Andrew P DeFilippis ◽  
Holly J Kramer ◽  
Ronit Katz ◽  
Nathan Wong ◽  
Alain Bertoni ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
Albumin Creatinine Ratio ◽  
Ethnic Study ◽  
Median Increase ◽  
Increased Risk ◽  
History Of ◽  
Relationship Of ◽  
The Relationship ◽  
Progression Of Atherosclerosis

Background: Microalbuminuria (MA) is associated with an increased risk of cardiovascular disease (CVD) but the mechanism by which microalbuminuria imparts this increased risk is not known. In this study we assessed the relationship between MA and the development and progression of atherosclerosis by measuring the incidence of new CAC and the progression of existing CAC in individuals free of clinical CVD. Methods : The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study of 6,814 participants free of clinical CVD at entry who underwent assessment of coronary artery calcification (CAC) by computerized tomography at baseline. Overall, 6,775 individuals had data available on urinary albumin creatinine ratio (UACR); 1,109 individuals were excluded for missing data or macroalbuminuria (UACR≥300 mg/g). Incident CAC was defined as detectable CAC at follow-up among those with CAC=0 at baseline, and absolute CAC score change among those with CAC>0 at baseline. Relative risk (RR) regression adjusted for covariates; and multivariable adjusted median regression was employed to assess the independent relationship of MA with CAC incidence and progression. Results : Of the 5,666 subjects (mean age 62±10 years, 48% males), baseline MA was seen in 424 (7%) participants, who were more likely to have CAC compared to those with normal UACR (62% vs. 48%, p<0.0001). During a mean follow-up of 2.4±0.8 years, those with MA were more likely to develop CAC (28% vs. 15%, p<0.0001) and they had a higher absolute median increase in CAC (47 vs. 29 Agatston Units, p<0.0001). After adjustment for age, gender, ethnicity, site, follow-up duration, diabetes, hypertension, smoking, family history of heart attack, total cholesterol, lipid lowering medications and body mass index; MA was associated with incident CAC (RR 1.65; 95%CI 1.41–2.48) among those with CAC=0 at baseline. Among those with CAC>0 at baseline, MA was associated with a median increase in CAC of 7.93 (95%CI 0.38 –15.47) Agatston Units in multivariable adjusted analyses (variables noted above). Conclusion : MA is independently associated with development of incident CAC and progression of CAC in an asymptomatic multi-ethnic population, and may in part explain its associated increased risk of CVD.

INFLUENCE OF STRAIN AND SEX ON THE RELATIONSHIP OF PROTEIN TO ENERGY IN THE RATIONS OF GROWING AND FINISHING BACON PIGS

1959 ◽  
Vol 39 (1) ◽  
pp. 102-114 ◽  
Author(s):  
J. P. Bowland ◽  
R. T. Berg
Keyword(s):  
Feed Efficiency ◽  
Carcass Characteristics ◽  
Strain Differences ◽  
High Energy ◽  
Low Energy ◽  
High Protein ◽  
Growing Period ◽  
Strain Interaction ◽  
Relationship Of ◽  
The Relationship

Rations varying in energy (65 to 79 per cent TDN or 69 to 88 per cent apparent digestible energy) and protein (13 to 21 per cent) were studied in two experiments with 120 pigs of four strains. Rate of liveweight gain tended to be fastest in pigs fed high energy-high protein rations throughout. Males gained more rapidly than females, with strain differences being evident. Strain × sex interactions in rate of gain were present in both the growing and finishing period, with a ration × strain interaction present in the growing period. There was an indication that in the growing period pigs on high energy, particularly high energy-high protein rations ate more than pigs fed low energy rations. In the finishing period low energy rations were consumed at a higher rate than high energy rations with protein level having no influence on feed intake. In the growing period to 110 pounds, high protein rations resulted in improved feed efficiency as compared to medium protein rations, while in the finishing period to market weight high energy rations were more efficient than low energy rations. There was evidence that high protein alone or in combination with high energy rations also improved efficiency of feed utilization in the finishing period. Female pigs required less feed per pound gain than male pigs in the finishing period. High energy rations resulted in increased dressing percentage and generally inferior carcasses. There was an indication that high protein rations resulted in leaner carcasses. Carcass length was not influenced by ration. Carcasses from female pigs excelled those from male pigs in all factors measured except carcass length. Strain differences in carcass characteristics existed but no appreciable strain × ration interactions were noted.

scholarly journals Gender Dictates the Relationship between Serum Lipids and Leukocyte Counts in the National Health and Nutrition Examination Survey 1999–2004

2019 ◽  
Vol 8 (3) ◽  
pp. 365 ◽  
Author(s):  
Catherine Andersen ◽  
Terrence Vance
Keyword(s):  
Total Cholesterol ◽  
National Health ◽  
Blood Lymphocyte ◽  
Serum Lipids ◽  
Lipid Lowering ◽  
Nutrition Examination Survey ◽  
Men And Women ◽  
Health And Nutrition ◽  
Leukocyte Counts ◽  
The Relationship

Dyslipidemias and leukocytosis are associated with cardiovascular disease and immune disorders. Mechanistic studies have shown lipoprotein metabolism to play a significant role in the regulation of atherosclerosis development and leukocyte activation, whereas lipid-lowering treatments have been shown to exert beneficial anti-inflammatory and immunomodulatory effects in clinical trials. However, the relationship between clinical markers of lipid metabolism and leukocyte counts has not been extensively evaluated at the population level. We aimed to determine whether clinical blood lipid measures are associated with leukocyte counts in the general U.S. population represented in the National Health and Nutrition Examination Survey (NHANES) 1999–2004, and whether differences exist between men and women (n = 5647). We observed a strong positive linear trend between serum triglycerides vs. blood lymphocyte and basophil counts in both men and women, whereas a positive trend between monocytes vs. triglycerides and lymphocytes vs. total cholesterol and LDL-cholesterol (LDL-C) was only detected in women. Conversely, HDL-C was inversely associated with a greater number of leukocyte subsets in men, whereas inverse trends between HDL-C vs. lymphocytes were observed in both men and women. In multiple regression models, a 10% increase in total cholesterol, LDL-C, and triglycerides was associated with a predicted 1.6%, 0.6%, and 1.4% increase in blood lymphocyte counts in women, respectively, whereas no relationship was observed in men. In both men and women, a 10% increase in triglycerides was additionally associated with higher lymphocyte, neutrophil, and basophil counts, whereas 10% increases in HDL-cholesterol were associated with significantly lower lymphocyte, neutrophil, eosinophil, and basophil counts in men, in addition to lower lymphocyte and monocyte counts in women. These findings suggest that clinical lipid markers may be used to predict blood leukocyte distributions, and that a gender-specific relationship exists between distinct classes of serum lipids and immune cell subsets.

scholarly journals Salivary AMY1 Copy Number Variation Modifies Age-Related Type 2 Diabetes Risk

2020 ◽  
Vol 66 (5) ◽  
pp. 718-726
Author(s):  
Yuwei Liu ◽  
Caren E Smith ◽  
Laurence D Parnell ◽  
Yu-Chi Lee ◽  
Ping An ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Copy Number Variation ◽  
Metabolic Pathway ◽  
Copy Number ◽  
Lipid Lowering ◽  
Pathway Enrichment Analysis ◽  
Copy Numbers ◽  
Number Variation ◽  
The Relationship

Abstract Background Copy number variation (CNV) in the salivary amylase gene (AMY1) modulates salivary α-amylase levels and is associated with postprandial glycemic traits. Whether AMY1-CNV plays a role in age-mediated change in insulin resistance (IR) is uncertain. Methods We measured AMY1-CNV using duplex quantitative real-time polymerase chain reaction in two studies, the Boston Puerto Rican Health Study (BPRHS, n = 749) and the Genetics of Lipid-Lowering Drug and Diet Network study (GOLDN, n = 980), and plasma metabolomic profiles in the BPRHS. We examined the interaction between AMY1-CNV and age by assessing the relationship between age with glycemic traits and type 2 diabetes (T2D) according to high or low copy numbers of the AMY1 gene. Furthermore, we investigated associations between metabolites and interacting effects of AMY1-CNV and age on T2D risk. Results We found positive associations of IR with age among subjects with low AMY1-copy-numbers in both studies. T2D was marginally correlated with age in participants with low AMY1-copy-numbers but not with high AMY1-copy-numbers in the BPRHS. Metabolic pathway enrichment analysis identified the pentose metabolic pathway based on metabolites that were associated with both IR and the interactions between AMY1-CNV and age. Moreover, in older participants, high AMY1-copy-numbers tended to be associated with lower levels of ribonic acid, erythronic acid, and arabinonic acid, all of which were positively associated with IR. Conclusions We found evidence supporting a role of AMY1-CNV in modifying the relationship between age and IR. Individuals with low AMY1-copy-numbers tend to have increased IR with advancing age.

scholarly journals Relationships among oil content, protein content and seed size in soybeans

2001 ◽  
Vol 44 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Mario Marega Filho ◽  
Deonisio Destro ◽  
Lilian Azevedo Miranda ◽  
Wilma Aparecida Spinosa ◽  
Mercedes Concórdia Carrão-Panizzi ◽  
...  
Keyword(s):  
Protein Content ◽  
Seed Size ◽  
Oil Content ◽  
High Protein ◽  
Human Consumption ◽  
State University ◽  
Environmental Correlations ◽  
High Protein Content ◽  
Soybean Genotypes ◽  
The Relationship

During 1995/96 and 1996/97, experiments were carried out at Londrina State University, aiming at quantifying the oil and protein contents in two groups of soybean genotypes; estimating the phenotypic, genotypic and environmental correlations existent among oil, protein content and seed size, and identifying genotypes for direct human consumption with high protein content. The evaluated characters were Weight of a Hundred Seeds (WHS), expressed in grams/100 seeds, Oil Content (OC) and Protein Content (PC), expressed in %. In the experiment carried out in the field, OC ranged from 12 to 20.37 % and PC from 35.66 to 41.75% while in the experiment carried out in the greenhouse OC ranged from 12.26 to 21.79 % and PC from 32.95 to 41.56 % . The correlations between oil and protein were negative and significant. The relationship among WHS with OC and PC was low and higly affected by the time effect. Due to their high protein content and stability to oil and protein contents, there were distinction among the treatments carried out in the field (GA23 and GA20), and those carried out in the greenhouse (PI408251, Waseda, B6F4 (L-3 less), PI423909 and Tambagura).

The effect of plane of nutrition on the body composition of two breeds of wearier sheep fed a high protein diet

1982 ◽  
Vol 98 (2) ◽  
pp. 241-245 ◽  
Author(s):  
T. W. Searle ◽  
N. McC. Graham ◽  
J. B. Donnelly
Keyword(s):  
Body Weight ◽  
Live Weight ◽  
High Protein Diet ◽  
The Body ◽  
High Protein ◽  
The Other ◽  
Protein Diet ◽  
Castrate Male ◽  
Body Component ◽  
The Relationship

SUMMARYCorriedale and Dorset Horn castrate male (wether) lambs reared at pasture were weaned at 19 kg live weight (LW), brought indoors and fed a high protein diet such that half of each group grew at ca. 200 g/day and the other half at ca. 100 g/day. Animals were slaughtered at 25 and 30 kg LW and chemical composition (protein, fat, energy, water and ash) of the body determined. The relationship between each body component and shorn empty-body weight was examined by regression analysis.Within levels of feeding the results were similar in the two breeds. When comparisons were made between feeding levels, the slower-growing animals contained more fat, energy and ash than the faster-growing group, less water, but similar amounts of protein at any given empty-body weight.

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