Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet

2020 ◽  
Vol 11 (8) ◽  
pp. 6818-6833
Author(s):  
Wei-Ling Guo ◽  
Jian-Bin Guo ◽  
Bin-Yu Liu ◽  
Jin-Qiang Lu ◽  
Min Chen ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Ganoderma Lucidum ◽  
Metabolite Profile ◽  
Microbiota Composition ◽  
High Fat ◽  
Ganoderic Acid ◽  
Gut Microbiota Composition

Ganoderic acid A from Ganoderma lucidum has the potential to prevent hyperlipidemia, modulates the composition of gut microbiota in hyperlipidemic mice, and significantly attenuates the liver metabolite profile in hyperlipidemic mice.

Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats

2018 ◽  
Vol 9 (6) ◽  
pp. 3419-3431 ◽  
Author(s):  
Wei-Ling Guo ◽  
Yu-Yang Pan ◽  
Lu Li ◽  
Tian-Tian Li ◽  
Bin Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Ganoderma Lucidum ◽  
Metabolic Disorders ◽  
Ethanol Extract ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition ◽  
Mrna Expression Levels

Ethanol extract from Ganoderma lucidum (GL95), enriched with triterpenoids, has the potential to ameliorate lipid metabolic disorders, in part through modulating specific gut microbiota and regulating the mRNA expression levels of the genes involved in lipid and cholesterol.

Effect of Grifola frondosa 95% ethanol extract on lipid metabolism and gut microbiota composition in high-fat diet-fed rats

2018 ◽  
Vol 9 (12) ◽  
pp. 6268-6278 ◽  
Author(s):  
Yu-Yang Pan ◽  
Feng Zeng ◽  
Wei-Ling Guo ◽  
Tian-Tian Li ◽  
Rui-Bo Jia ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
Grifola Frondosa ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition

This study aimed to investigate the effects of 95% ethanol extract of G. frondosa (GF95) on lipid metabolism and gut microbiota composition in high-fat diet (HFD) fed rats.

scholarly journals Whole Grain Qingke Attenuates High-Fat Diet-Induced Obesity in Mice With Alterations in Gut Microbiota and Metabolite Profile

2021 ◽  
Vol 8 ◽  
Author(s):  
Xipu Li ◽  
Jingqi Suo ◽  
Xinguo Huang ◽  
Huifen Dai ◽  
Hongwu Bian ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Unsaturated Fatty Acids ◽  
Metabolite Profile ◽  
Lipid Lowering ◽  
Microbiota Composition ◽  
Whole Grain ◽  
High Fat ◽  
Gut Microbiota Composition

Whole grain Qingke (WGQK) displays anti-obesity and lipid-lowering properties; however, the underlying mechanism remains elusive. This study investigated the alteration of gut microbiota composition and metabolite profile induced by WGQK intervention in mice through the integration of 16S ribosomal RNA (rRNA) sequencing and an untargeted metabolomics study. C57BL/6J male mice were fed a normal control diet (NC), high-fat diet (HFD), and HFD plus 30% WGQK (HFD+QK) for 16 weeks. The WGQK intervention decreased body weight gain, glucose tolerance, and serum lipid levels, and alleviated liver function damage induced by HFD. Moreover, WGQK changed gut microbiota composition and enriched specific genera such as Akkermansia, Bifidobacterium, and Lactobacillus. Fecal metabolomics analysis indicated that WGQK enhanced the abundance of tryptophan metabolism-related metabolites (indole, 3-indoleacetic acid, indole acetic acid (IAA), 5-hydroxyindole-3-acetic acid), histidine metabolism-related metabolites (histamine), and some unsaturated fatty acids (oleic acid, 9,10-dihydroxy-12Z-octadecenoic acid, and alpha-linolenic acid). Spearman correlation analysis revealed that these metabolites were negatively correlated with obesity-related parameters and positively correlated with the gut genera enriched by WGQK. Moreover, WGQK promoted the expression of Cholesterol 7α-hydroxylase (CYP7A1) responsible for primary bile acids production, accompanied by a decline in intestinal FXR-FGF15 expression levels. The transcript levels of two genes associated with lipogenesis, such as lipid fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) were also decreased in the HFD+QK group. Overall, our results suggest interactions between gut microbial shifts and host amino acid/lipid metabolism, and shed light on the mechanisms underlying the anti-obesity effect of WGQK.

Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet

2021 ◽  
Author(s):  
Yilin Liu ◽  
Chunyan Xie ◽  
Zhenya Zhai ◽  
Ze-yuan Deng ◽  
Hugo R. De Jonge ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Fat Accumulation ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Gut Microbiota Composition

This study aimed to investigate the effect of uridine on obesity, fat accumulation in liver, and gut microbiota composition in high-fat diet-fed mice.

Yeast β-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models

2021 ◽  
Author(s):  
Sik Yu So ◽  
Qinglong Wu ◽  
Kin Sum Leung ◽  
Zuzanna Maria Kundi ◽  
Tor C Savidge ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Health ◽  
Metabolic Phenotype ◽  
Bile Acid Metabolism ◽  
Microbiota Composition ◽  
High Fat ◽  
Mrna Accumulation ◽  
Gut Microbiota Composition

Emerging evidence links dietary fiber with altered gut microbiota composition and bile acid signaling in maintaining metabolic health. Yeast β-glucan (Y-BG) is a dietary supplement known for its immunomodulatory effect, yet its impact on the gut microbiota and bile acid composition remains unclear. This study investigated whether dietary forms of Y-BG modulate these gut-derived signals. We performed 4-week dietary supplementation in healthy mice to evaluate effects of different fiber composition (soluble vs particulate Y-BG) and dose (0.1 vs. 2%). We found that 2% particulate Y-BG induced robust gut microbiota community shifts with elevated liver Cyp7a1 mRNA abundance and bile acid synthesis. These diet-induced responses were notably different when compared to the prebiotic inulin, and included a marked reduction in fecal Bilophila abundance which we demonstrated as translatable to obesity in population-scale American Gut and TwinsUK clinical cohorts. This prompted us to test whether 2% Y-BG maintained metabolic health in mice fed 60% HFD over 13 weeks. Y-BG consistently altered the gut microbiota composition and reduced Bilophila abundance, with trends observed in improvement of metabolic phenotype. Notably, Y-BG improved insulin sensitization and this was associated with enhanced ileal Glpr1r mRNA accumulation and reduced Bilophila abundance. Collectively, our results demonstrate that Y-BG modulates gut microbiota community composition and bile acid signaling, but the dietary regime needs to be optimized to facilitate clinical improvement in metabolic phenotype in an aggressive high-fat diet animal model.

Dietary wood pulp-derived sterols modulation of cholesterol metabolism and gut microbiota in high-fat-diet-fed hamsters

2019 ◽  
Vol 10 (2) ◽  
pp. 775-785 ◽  
Author(s):  
Xiang Li ◽  
Huali Wang ◽  
Tianxin Wang ◽  
Fuping Zheng ◽  
Hao Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorder ◽  
Cholesterol Metabolism ◽  
Wood Pulp ◽  
Microbiota Composition ◽  
High Fat ◽  
Fecal Sterols ◽  
Gut Microbiota Composition

Wood pulp-derived sterols (WS) supplementation ameliorated HFD-associated metabolic disorder; WS supplementation increased the amounts of fecal sterols excretion and SCFAs content; WS supplementation modulated gut microbiota composition.

scholarly journals Effect of A Polyphenol-Rich Canarium album Extract on the Composition of the Gut Microbiota of Mice Fed a High-Fat Diet

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2188 ◽  
Author(s):  
Ning-Ning Zhang ◽  
Wen-Hui Guo ◽  
Han Hu ◽  
A-Rong Zhou ◽  
Qing-Pei Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
High Throughput Sequencing ◽  
Chow Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Canarium Album ◽  
Normal Chow ◽  
Gut Microbiota Composition ◽  
Medium Dose

This study investigated the influence of Canarium album extract (CAext) on intestinal microbiota composition of mice fed a high-fat diet (HFD). Kun Ming (KM) mice were fed either a normal chow diet or a HFD for six weeks. At the seventh week, HFD-fed mice were gavaged daily with saline, or a different dose of CAext for four weeks, respectively. Then, the composition of the gut microbiota was analyzed by high-throughput sequencing technology. Analysis of fecal microbial populations, grouped by phyla, showed significant increases of Firmicutes and Verrucomicrobia, but a decrease of Bacteroidetes in all CAext-fed mice. Particularly, CAext gavage in a low dose or a medium dose caused a significant increase in the proportion of Akkermansia. These findings suggested that CAext can alter the gut microbiota composition of HFD-fed mice, and had a potential prebiotic effects on Akkermansia.

Anti-obesity effects of α-amylase inhibitor enriched-extract from white common beans (Phaseolus vulgaris L.) associated with the modulation of gut microbiota composition in high-fat diet-induced obese rats

2020 ◽  
Vol 11 (2) ◽  
pp. 1624-1634 ◽  
Author(s):  
Zhenxing Shi ◽  
Yingying Zhu ◽  
Cong Teng ◽  
Yang Yao ◽  
Guixing Ren ◽  
...  
Keyword(s):  
Phaseolus Vulgaris ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
Common Beans ◽  
Phaseolus Vulgaris L ◽  
High Fat ◽  
Obese Rats ◽  
Amylase Inhibitors ◽  
Gut Microbiota Composition

α-Amylase inhibitors (α-AI) have great potential to treat obesity.

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