Anti-obesity effects of α-amylase inhibitor enriched-extract from white common beans (Phaseolus vulgaris L.) associated with the modulation of gut microbiota composition in high-fat diet-induced obese rats

2020 ◽  
Vol 11 (2) ◽  
pp. 1624-1634 ◽  
Author(s):  
Zhenxing Shi ◽  
Yingying Zhu ◽  
Cong Teng ◽  
Yang Yao ◽  
Guixing Ren ◽  
...  
Keyword(s):  
Phaseolus Vulgaris ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
Common Beans ◽  
Phaseolus Vulgaris L ◽  
High Fat ◽  
Obese Rats ◽  
Amylase Inhibitors ◽  
Gut Microbiota Composition

α-Amylase inhibitors (α-AI) have great potential to treat obesity.

Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet

2021 ◽  
Author(s):  
Yilin Liu ◽  
Chunyan Xie ◽  
Zhenya Zhai ◽  
Ze-yuan Deng ◽  
Hugo R. De Jonge ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Fat Accumulation ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Gut Microbiota Composition

This study aimed to investigate the effect of uridine on obesity, fat accumulation in liver, and gut microbiota composition in high-fat diet-fed mice.

Yeast β-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models

2021 ◽  
Author(s):  
Sik Yu So ◽  
Qinglong Wu ◽  
Kin Sum Leung ◽  
Zuzanna Maria Kundi ◽  
Tor C Savidge ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Health ◽  
Metabolic Phenotype ◽  
Bile Acid Metabolism ◽  
Microbiota Composition ◽  
High Fat ◽  
Mrna Accumulation ◽  
Gut Microbiota Composition

Emerging evidence links dietary fiber with altered gut microbiota composition and bile acid signaling in maintaining metabolic health. Yeast β-glucan (Y-BG) is a dietary supplement known for its immunomodulatory effect, yet its impact on the gut microbiota and bile acid composition remains unclear. This study investigated whether dietary forms of Y-BG modulate these gut-derived signals. We performed 4-week dietary supplementation in healthy mice to evaluate effects of different fiber composition (soluble vs particulate Y-BG) and dose (0.1 vs. 2%). We found that 2% particulate Y-BG induced robust gut microbiota community shifts with elevated liver Cyp7a1 mRNA abundance and bile acid synthesis. These diet-induced responses were notably different when compared to the prebiotic inulin, and included a marked reduction in fecal Bilophila abundance which we demonstrated as translatable to obesity in population-scale American Gut and TwinsUK clinical cohorts. This prompted us to test whether 2% Y-BG maintained metabolic health in mice fed 60% HFD over 13 weeks. Y-BG consistently altered the gut microbiota composition and reduced Bilophila abundance, with trends observed in improvement of metabolic phenotype. Notably, Y-BG improved insulin sensitization and this was associated with enhanced ileal Glpr1r mRNA accumulation and reduced Bilophila abundance. Collectively, our results demonstrate that Y-BG modulates gut microbiota community composition and bile acid signaling, but the dietary regime needs to be optimized to facilitate clinical improvement in metabolic phenotype in an aggressive high-fat diet animal model.

Dietary wood pulp-derived sterols modulation of cholesterol metabolism and gut microbiota in high-fat-diet-fed hamsters

2019 ◽  
Vol 10 (2) ◽  
pp. 775-785 ◽  
Author(s):  
Xiang Li ◽  
Huali Wang ◽  
Tianxin Wang ◽  
Fuping Zheng ◽  
Hao Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorder ◽  
Cholesterol Metabolism ◽  
Wood Pulp ◽  
Microbiota Composition ◽  
High Fat ◽  
Fecal Sterols ◽  
Gut Microbiota Composition

Wood pulp-derived sterols (WS) supplementation ameliorated HFD-associated metabolic disorder; WS supplementation increased the amounts of fecal sterols excretion and SCFAs content; WS supplementation modulated gut microbiota composition.

scholarly journals Effect of A Polyphenol-Rich Canarium album Extract on the Composition of the Gut Microbiota of Mice Fed a High-Fat Diet

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2188 ◽  
Author(s):  
Ning-Ning Zhang ◽  
Wen-Hui Guo ◽  
Han Hu ◽  
A-Rong Zhou ◽  
Qing-Pei Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
High Throughput Sequencing ◽  
Chow Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Canarium Album ◽  
Normal Chow ◽  
Gut Microbiota Composition ◽  
Medium Dose

This study investigated the influence of Canarium album extract (CAext) on intestinal microbiota composition of mice fed a high-fat diet (HFD). Kun Ming (KM) mice were fed either a normal chow diet or a HFD for six weeks. At the seventh week, HFD-fed mice were gavaged daily with saline, or a different dose of CAext for four weeks, respectively. Then, the composition of the gut microbiota was analyzed by high-throughput sequencing technology. Analysis of fecal microbial populations, grouped by phyla, showed significant increases of Firmicutes and Verrucomicrobia, but a decrease of Bacteroidetes in all CAext-fed mice. Particularly, CAext gavage in a low dose or a medium dose caused a significant increase in the proportion of Akkermansia. These findings suggested that CAext can alter the gut microbiota composition of HFD-fed mice, and had a potential prebiotic effects on Akkermansia.

scholarly journals The impact of exercise training and resveratrol supplementation on gut microbiota composition in high-fat diet fed mice

2018 ◽  
Vol 6 (20) ◽  
pp. e13881 ◽  
Author(s):  
Nina Brandt ◽  
Dorota Kotowska ◽  
Caroline M. Kristensen ◽  
Jesper Olesen ◽  
Ditte O. Lützhøft ◽  
...  
Keyword(s):  
Exercise Training ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
The Impact ◽  
Gut Microbiota Composition

Garcinol Reduces Obesity in High‐Fat‐Diet‐Fed Mice by Modulating Gut Microbiota Composition

2018 ◽  
Vol 63 (2) ◽  
pp. 1800390 ◽  
Author(s):  
Pei‐Sheng Lee ◽  
Chia‐Yi Teng ◽  
Nagabhushanam Kalyanam ◽  
Chi‐Tang Ho ◽  
Min‐Hsiung Pan
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition

Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet

2020 ◽  
Vol 11 (8) ◽  
pp. 6818-6833
Author(s):  
Wei-Ling Guo ◽  
Jian-Bin Guo ◽  
Bin-Yu Liu ◽  
Jin-Qiang Lu ◽  
Min Chen ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Ganoderma Lucidum ◽  
Metabolite Profile ◽  
Microbiota Composition ◽  
High Fat ◽  
Ganoderic Acid ◽  
Gut Microbiota Composition

Ganoderic acid A from Ganoderma lucidum has the potential to prevent hyperlipidemia, modulates the composition of gut microbiota in hyperlipidemic mice, and significantly attenuates the liver metabolite profile in hyperlipidemic mice.

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