Jiaogulan tea (Gpostemma pentaphyllum) potentiates the antidiabetic effect of white tea via the AMPK and PI3K pathways in C57BL/6 mice

2020 ◽  
Vol 11 (5) ◽  
pp. 4339-4355 ◽  
Author(s):  
Xiaoyan Xia ◽  
Jing Xu ◽  
Xude Wang ◽  
Hua Wang ◽  
Zhenchuan Lin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Antidiabetic Effect ◽  
White Tea ◽  
Onset Of Diabetes

The use of plant-based beverages to interfere with the onset of diabetes may be a promising approach towards type 2 diabetes mellitus (T2DM).

Exercise Pressor Reflex in UC Davis Type‐2 Diabetes Mellitus (UCD‐T2DM) Rats Prior to the Onset of Diabetes

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Yu Huo ◽  
Ann-Katrin Grotle ◽  
Junghoon Lee ◽  
Kai M. Ybarbo ◽  
James Graham ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Exercise Pressor Reflex ◽  
Onset Of Diabetes ◽  
Pressor Reflex

scholarly journals Beneficial Effects of Vitamin K Status on Glycemic Regulation and Diabetes Mellitus: A Mini-Review

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2485
Author(s):  
Hsin-Jung Ho ◽  
Michio Komai ◽  
Hitoshi Shirakawa
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Vitamin K ◽  
Glycemic Status ◽  
Beneficial Effects ◽  
Onset Of Diabetes ◽  
Glycemic Regulation

Type 2 diabetes mellitus is a chronic disease that is characterized by hyperglycemia, insulin resistance, and dysfunctional insulin secretion. Glycemic control remains a crucial contributor to the progression of type 2 diabetes mellitus as well as the prevention or delay in the onset of diabetes-related complications. Vitamin K is a fat-soluble vitamin that plays an important role in the regulation of the glycemic status. Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity. This mini-review summarizes the recent insights into the beneficial effects of vitamin K and its possible mechanism of action on insulin sensitivity and glycemic status, thereby suppressing the progression of diabetes mellitus.

scholarly journals Prevalence of diabetic retinopathy in type 2 diabetes mellitus patients attending medicine out-patient department of a tertiary care hospital in Alappuzha, Kerala, India

2017 ◽  
Vol 5 (4) ◽  
pp. 1532 ◽  
Author(s):  
Koushiki Mani ◽  
Rose Davy C.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Age At Onset ◽  
Proliferative Retinopathy ◽  
Duration Of Diabetes ◽  
Onset Of Diabetes ◽  
Patient Department

Background: Diabetic retinopathy is a microvascular complication affecting the eyes of both Type 1 and Type 2 diabetes mellitus due to long-term hyperglycaemia. Diabetic retinopathy is the leading cause of blindness among working aged adults around the world. There are various factors leading to the development of diabetic retinopathy namely duration of diabetes, glycaemic control, age at onset of diabetes, uncontrolled hypertension. This is a hospital based cross-sectional study which aimed to study the prevalence of diabetic retinopathy in type 2 diabetes mellitus patients attending Medicine out-patient department of Government T. D. Medical College, Alappuzha, Kerala, India. The factors contributing to the development of retinopathy was also studied.Methods: 200 already diagnosed type 2 diabetic subjects were included in the study. Subjects were explained about the study and once the consent was received, data regarding age, gender, age at onset of diabetes, duration of diabetes, history of smoking, alcohol intake, and socio-economic status was documented. Height and weight was measured. Blood pressure was recorded with mercury sphygmomanometer. Then the subjects were evaluated for diabetic retinopathy by fundus examination after dilating the eyes. Findings were noted and subjects were categorized as no retinopathy, nonproliferative and proliferative diabetic retinopathy using the ETDRS classification.Results: In present study, out of 200 subjects, 63 subjects (31.5%) were affected with diabetic retinopathy (non-proliferative retinopathy=22.5%, proliferative retinopathy=9%). Prevalence of mild, moderate and severe non-proliferative retinopathy was 7.5% each. Significant association was found between diabetic retinopathy and duration of diabetes.Conclusions: Therefore, periodic screening of diabetic patients should be carried out for early detection and prevention of loss of vision.

scholarly journals Progress in Metabonomics of Type 2 Diabetes Mellitus

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1834 ◽  
Author(s):  
Quantao Ma ◽  
Yaqi Li ◽  
Min Wang ◽  
Ziyan Tang ◽  
Ting Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Pathways ◽  
Theoretical Basis ◽  
Living Standards ◽  
Effective Prevention ◽  
Before And After ◽  
Onset Of Diabetes

With the improvement of living standards and a change in lifestyle, the incidence of type 2 diabetes mellitus (T2DM) is increasing. Its etiology is too complex to be completely understand yet. Metabonomics techniques are used to study the changes of metabolites and metabolic pathways before and after the onset of diabetes and make it more possible to further understand the pathogenesis of T2DM and improve its prediction, early diagnosis, and treatment. In this review, we summarized the metabonomics study of T2DM in recent years and provided a theoretical basis for the study of pathogenesis and the effective prevention and treatment of T2DM.

scholarly journals Moringa Isothiocyanate-rich Seed Extract Delays the Onset of Diabetes in UC Davis Type-2 Diabetes Mellitus Rats

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Carrie Waterman ◽  
James L. Graham ◽  
Charles D. Arnold ◽  
Kimber L. Stanhope ◽  
Jason H. Tong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Seed Extract ◽  
Onset Of Diabetes ◽  
Moringa Isothiocyanate

scholarly journals Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Ceren Eyileten ◽  
Agnieszka Kaplon-Cieslicka ◽  
Dagmara Mirowska-Guzel ◽  
Lukasz Malek ◽  
Marek Postula
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Neurotrophic Factor ◽  
Platelet Reactivity ◽  
Brain Derived Neurotrophic Factor ◽  
Diabetic Patients ◽  
Antidiabetic Effect ◽  
Coronary Syndrome

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF. We also reviewed the evidences of the antidiabetic effect of BDNF and the association with circulating inflammatory cytokines in T2DM.

Antidiabetic Effect of Karanja Seed Powder in Type-2 Diabetes Mellitus(DM)

2012 ◽  
Vol 2 (7) ◽  
pp. 268-269
Author(s):  
Dr. Poonam Sharma ◽  
◽  
Dr. Ajay Kr Sharma ◽  
K. N. Dwivedi K. N. Dwivedi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Antidiabetic Effect

scholarly journals Correlation Between Onset of Diabetes Mellitus and Nitric Oxide Levels in Patient with Type 2 Diabetes Mellitus

2018 ◽  
Vol 4 (1) ◽  
pp. 8
Author(s):  
Theosobia Grace Orno ◽  
Mansyur Arif ◽  
Irfan Idris
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cross Sectional ◽  
Type 2 Dm ◽  
Increased Risk ◽  
Significant Difference ◽  
Onset Of Diabetes

Type 2 diabetes mellitus (DM) is associated with increased risk of endothelial dysfunction if it lasts a long time without control. This study aims to connect the Onset of Diabetes Mellitus (DM) with Nitric Oxide levels in patients of type 2 diabetes mellitus. The study used cross-sectional study method. The samples were 86 subjects, consisting of 38 subjects of Type 2 DM controlled and 48 subjects of Type 2 DM uncontrolled. The results of the Kruskal-Wallis statistical test showed no significant difference between the Onset of DM and Nitric Oxide levels in the categories of 4-6 years (19.4 ± 10.1), 7-9 years (17.3 ± 9.3) and 10-12 years (13.3 ± 8.5) (p=0.06). Furthermore, the Spearman correlation test revealed a negative correlation between the Onset of DM and Nitric Oxide level in patients with Type 2 DM with and without control (r =-0.217). The level of Nitric Oxide (NO) can consider as a predictor of long-term complication in patients with type 2 DM.

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