Water-soluble cyclometalated Ir(iii) complexes as carrier-free and pure nanoparticle photosensitizers for photodynamic therapy and cell imaging

2020 ◽  
Vol 49 (33) ◽  
pp. 11493-11497
Author(s):  
Xiaofan Tong ◽  
Liping Zhang ◽  
Lijuan Li ◽  
Yite Li ◽  
Zhiyu Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Imaging ◽  
Water Soluble ◽  
Carrier Free ◽  
First Time

A facile strategy to obtain water-soluble cyclometalated Ir(iii) complexes as carrier-free and pure nanoparticle photosensitizers for PDT and cell imaging is provided for the first time.

Water-Soluble Conjugated Polymers for Simultaneous Two-Photon Cell Imaging and Two-Photon Photodynamic Therapy

2013 ◽  
Vol 1 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Xiaoqin Shen ◽  
Lin Li ◽  
Agnes Chow Min Chan ◽  
Nengyue Gao ◽  
Shao Q. Yao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Cell Imaging ◽  
Water Soluble ◽  
Two Photon

A zwitterionic red-emitting water-soluble conjugated polymer with high resistance to nonspecific binding for two-photon cell imaging and good singlet oxygen production capability

2021 ◽  
Author(s):  
Yan-Qin Huang ◽  
Shan-Shan Jiang ◽  
Li-Xiang Pan ◽  
Rui Zhang ◽  
Kun-Lin Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
High Resistance ◽  
Conjugated Polymer ◽  
Cell Imaging ◽  
Water Soluble ◽  
Oxygen Production ◽  
Nonspecific Binding ◽  
Two Photon

Water-soluble conjugated polymers (WSCPs) with dual capability of two-photon imaging and singlet oxygen (1O2) production have become one type of the most promising agents in noninvasive imaging guided photodynamic therapy...

Water-Soluble, Zwitterionic Poly-photosensitizers as Carrier-Free, Photosensitizer-Self-Delivery System for in Vivo Photodynamic Therapy

2019 ◽  
Vol 11 (47) ◽  
pp. 44007-44017 ◽  
Author(s):  
Nan Zheng ◽  
Dan Xie ◽  
Chunsen Wang ◽  
Zhiyi Zhang ◽  
Yubin Zheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Delivery System ◽  
Water Soluble ◽  
Carrier Free

Synthesis of new water soluble silicon phthalocyanine substituted by linker sulfur atom and photophysicochemical studies for photodynamic therapy

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1398-1405 ◽  
Author(s):  
Göknur Yaşa Atmaca ◽  
Ali Erdoğmuş
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Sulfur Atom ◽  
Solvent Effects ◽  
Water Soluble ◽  
Quantum Yields ◽  
Good Solubility ◽  
Silicon Phthalocyanines ◽  
First Time ◽  
Soluble Silicon

In this work, 5-(trifluoromethyl)-2-thiopyridine substituted SiPc (1) and its quaternized derivative (2) were synthesized, and the effect of the linker sulfur atom on silicon phthalocyanines has been investigated for the first time in the literature. Both of the complexes have been characterized by standard spectroscopy methods. The complexes have good solubility in organic solvents and showed monomeric tendencies in all studied solvents. Only complex 2 had some aggregation in water because of solvent effects, as expected. In order to determine the therapeutic effect for cancer treatment, photophysicochemical properties were investigated in DMSO, DMF, toluene and water (for complex 2). The synthesized complexes were found to have about 3.5 times higher singlet oxygen quantum yields than the yields of unsubstituted SiPcCl2 ([Formula: see text] = 0.15 (in DMSO), 0.12 (in DMF), 0.10 (in toluene)) because of the effects of bulky axial groups.

Natrophosphate from the Ilímaussaq alkaline complex, South Greenland

2001 ◽  
pp. 139-141
Author(s):  
Ole V. Petersen ◽  
Alexander P. Khomyakov ◽  
Henning Sørensen
Keyword(s):  
Refractive Index ◽  
Kola Peninsula ◽  
Unit Cell Parameter ◽  
Cell Parameter ◽  
Water Soluble ◽  
Type Locality ◽  
Drill Core ◽  
Alkaline Complex ◽  
First Time ◽  
Alkaline Complexes

NOTE: This article was published in a former series of GEUS Bulletin. Please use the original series name when citing this article, for example: Petersen, O. V., Khomyakov, A. P., & Henning. (2001). Natrophosphate from the Ilímaussaq alkaline complex, South Greenland. Geology of Greenland Survey Bulletin, 190, 139-141. https://doi.org/10.34194/ggub.v190.5184 _______________ The rare mineral natrophosphate has been identified for the first time in the Ilímaussaq alkaline complex in a drill core from the Kvanefjeld area. It occurs sparsely in zoned veinlets with cores of natrophosphate and borders of fibrous trona. The natrophosphate is more or less smoky, transparent and unaltered. The refractive index n = 1.448 ± 0.005 is low compared to that given for the material from the type locality, Khibina alkaline complex, Kola Peninsula; the unit cell parameter a = 27.76 ± 0.05 Å is in excellent agreement with that given for the material from the type locality. The veins occur in hyper-agpaitic naujakasite lujavrite; villiaumite is an associated mineral. Only a few water-soluble minerals have so far been found in the Ilímaussaq alkaline complex compared to the wealth of such minerals in the Khibina and Lovozero alkaline complexes. This is possibly at least partly due to lack of necessary precautions during sampling.

Nitrogen and Sulfur Co-doped Fluorescent Carbon Dots for the Detection of Morin and Cell Imaging

2018 ◽  
Vol 15 (1) ◽  
pp. 47-55
Author(s):  
Xuebing Li ◽  
Haifen Yang ◽  
Ning Wang ◽  
Tijian Sun ◽  
Wei Bian ◽  
...  
Keyword(s):  
Microwave Heating ◽  
Fluorescent Probe ◽  
Fluorescence Intensity ◽  
Carbon Dots ◽  
Cell Imaging ◽  
Water Soluble ◽  
Heating Process ◽  
X Ray ◽  
Doped Carbon Dots ◽  
Co Doped

Background: Morin has many pharmacological functions including antioxidant, anticancer, anti-inflammatory, and antibacterial effects. It is commonly used in the treatment of antiviral infection, gastropathy, coronary heart disease and hepatitis B in clinic. However, researches have shown that morin is likely to show prooxidative effects on the cells when the amount of treatment is at high dose, leading to the decrease of intracellular ATP levels and the increase of necrosis process. Therefore, it is necessary to determine the concentration of morin in biologic samples. Method: Novel water-soluble and green nitrogen and sulfur co-doped carbon dots (NSCDs) were prepared by a microwave heating process with citric acid and L-cysteine. The fluorescence spectra were collected at an excitation wavelength of 350 nm when solutions of NSCDs were mixed with various concentrations of morin. Results: The as-prepared NSCDs were characterized by transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. The fluorescence intensity of NSCDs decreased significantly with the increase of morin concentration. The fluorescence intensity of NSCDs displayed a linear response to morin in the concentration 0.10-30 μM with a low detection limit of 56 nM. The proposed fluorescent probe was applied to analysis of morin in human body fluids with recoveries of 98.0-102%. Conclusion: NSCDs were prepared by a microwave heating process. The present analytical method is sensitive to morin. The quenching process between NSCDs and morin is attributed to the static quenching. In addition, the cellular toxicity on HeLa cells indicated that the as-prepared NSCDs fluorescent probe does not show obvious cytotoxicity in cell imaging. Our proposed method possibly opens up a rapid and nontoxic way for preparing heteroatom doped carbon dots with a broad application prospect.

scholarly journals Precisely Engineering a Carrier-free Hybrid Nanoassembly for Multimodal DNA Damage-augmented Photodynamic Therapy

2021 ◽  
pp. 130838
Author(s):  
Shumeng Li ◽  
Fujun Yang ◽  
Xinxin Sun ◽  
Yuequan Wang ◽  
Xuanbo Zhang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Photodynamic Therapy ◽  
Carrier Free

Water-Soluble Fluorescent Probes Based on Dendronized Polyfluorenes for Cell Imaging

2013 ◽  
Vol 34 (6) ◽  
pp. 539-547 ◽  
Author(s):  
Libin Bai ◽  
Wei Li ◽  
Jingtian Chen ◽  
Fuli Bo ◽  
Baoxiang Gao ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Cell Imaging ◽  
Water Soluble

A water-soluble hybrid[4]arene: synthesis, host–guest complexation and application in the construction of a supra-amphiphile

2016 ◽  
Vol 40 (5) ◽  
pp. 4756-4760 ◽  
Author(s):  
Bin Hua ◽  
Li Shao ◽  
Jiong Zhou ◽  
Guocan Yu
Keyword(s):  
Water Soluble ◽  
Ph Responsive ◽  
New Host ◽  
Recognition Motif ◽  
First Time

A water-soluble hybrid[4]arene was synthesized for the first time and its pH-responsive host–guest complexation with paraquat in water was investigated. This new host–guest recognition motif was further applied in the construction of a supra-amphiphile.

scholarly journals Live-Cell Imaging of Caspase Activation for High-Content Screening

2009 ◽  
Vol 14 (8) ◽  
pp. 956-969 ◽  
Author(s):  
Christophe Antczak ◽  
Toshimitsu Takagi ◽  
Christina N. Ramirez ◽  
Constantin Radu ◽  
Hakim Djaballah
Keyword(s):  
Cell Death ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Exposure Period ◽  
Live Cells ◽  
Assay Method ◽  
Caspase Activation ◽  
Fluorogenic Substrate ◽  
Automated Imaging ◽  
First Time

Caspases are central to the execution of programmed cell death, and their activation constitutes the biochemical hallmark of apoptosis. In this article, the authors report the successful adaptation of a high-content assay method using the DEVDNucView488™ fluorogenic substrate, and for the first time, they show caspase activation in live cells induced by either drugs or siRNA. The fluorogenic substrate was found to be nontoxic over an exposure period of several days, during which the authors demonstrate automated imaging and quantification of caspase activation of the same cell population as a function of time. Overexpression of the antiapoptotic protein Bcl-XL, alone or in combination with the inhibitor Z-VAD-FMK, attenuated caspase activation in HeLa cells exposed to doxorubicin, etoposide, or cell death siRNA. This method was further validated against 2 well-characterized NSCLC cell lines reported to be sensitive (H3255) or refractory (H2030) to erlotinib, where the authors show a differential time-dependent activation was observed for H3255 and no significant changes in H2030, consistent with their respective chemosensitivity profile. In summary, the results demonstrate the feasibility of using this newly adapted and validated high-content assay to screen chemical or RNAi libraries for the identification of previously uncovered enhancers and suppressors of the apoptotic machinery in live cells. ( Journal of Biomolecular Screening 2009:956-969)

Sign in / Sign up

Export Citation Format

Share Document