Water-Soluble, Zwitterionic Poly-photosensitizers as Carrier-Free, Photosensitizer-Self-Delivery System for in Vivo Photodynamic Therapy

2019 ◽  
Vol 11 (47) ◽  
pp. 44007-44017 ◽  
Author(s):  
Nan Zheng ◽  
Dan Xie ◽  
Chunsen Wang ◽  
Zhiyi Zhang ◽  
Yubin Zheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Delivery System ◽  
Water Soluble ◽  
Carrier Free

Water-soluble hypocrellin A nanoparticles as a photodynamic therapy delivery system

2009 ◽  
Vol 82 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Lin Zhou ◽  
Jia-Hong Zhou ◽  
Chao Dong ◽  
Fei Ma ◽  
Shao-Hua Wei ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Delivery System ◽  
Water Soluble ◽  
Hypocrellin A ◽  
Therapy Delivery

Water-soluble cyclometalated Ir(iii) complexes as carrier-free and pure nanoparticle photosensitizers for photodynamic therapy and cell imaging

2020 ◽  
Vol 49 (33) ◽  
pp. 11493-11497
Author(s):  
Xiaofan Tong ◽  
Liping Zhang ◽  
Lijuan Li ◽  
Yite Li ◽  
Zhiyu Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Imaging ◽  
Water Soluble ◽  
Carrier Free ◽  
First Time

A facile strategy to obtain water-soluble cyclometalated Ir(iii) complexes as carrier-free and pure nanoparticle photosensitizers for PDT and cell imaging is provided for the first time.

scholarly journals Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization

2013 ◽  
Vol 63 (2) ◽  
pp. 241-251 ◽  
Author(s):  
Ramesh Jakki ◽  
Muzammil Afzal Syed ◽  
Prabhakar Kandadi ◽  
Kishan Veerabrahma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Ternary Phase Diagram ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Size Analysis

The main objective of this work was to prepare a self-micro emulsifying drug delivery system (SMEDDS) for enhancement of oral bioavailability of domperidone, a poorly water soluble drug. The solubility of the drug was determined in various vehicles. A pseudo ternary phase diagram was constructed to identify the self-micro emulsification region. The in vitro self-micro emulsification properties and droplet size analysis of SMEDDS were studied following their addition to water under mild agitation. Further, the resultant formulations were investigated for clarity, phase separation, globule size, effect of pH and dilutions (1:100, 1:500, 1:1000) and freeze-thaw stability. The optimized formulation, SMEDDS-B used for in vitro dissolution and bioavailability assessment, contained oil (Labrafac CC, 25 %, m/m), surfactant (Tween 80, 55 %, m/m), and co-surfactant (Transcutol®, 20 %, m/m). The preliminary oral bioavailability of domperidone from SMEDDS was 1.92-fold higher compared to that of domperidone suspension in rats. The AUC0-24 and cmax values were 3.38 ± 0.81 μg h mL-1 and 0.44 ± 0.03 μg mL-1 for SMEDDS-B formulation in comparison with 1.74 ± 0.18 μg h mL-1 and 0.24 ± 0.02 μg mL-1 for domperidone suspension, suggesting a significant increase (p < 0.05) in oral bioavailability of domperidone from SMEDDSS.

DEVELOPMENT OF A PHOTOSENSITIZER DELIVERY SYSTEM FOR THERAPY AND DIAGNOSTICS IN ONCOLOGY

2020 ◽  
pp. 124-125
Author(s):  
A.Semkina Semkina ◽  
M.Abakumov Abakumov ◽  
P.Ostroverkhov Ostroverkhov ◽  
M. Grin
Keyword(s):  
Photodynamic Therapy ◽  
Physicochemical Properties ◽  
Tumor Cells ◽  
Therapeutic Effect ◽  
Delivery System ◽  
Biological Studies ◽  
Kinetics Of ◽  
Ct26 Tumor

In this work, the MNP-HSA-PEG-PS@4 complex was obtained and its physicochemical properties were studied. Biological studies have also been conducted. Namely, the ability of the drug to accumulate in CT26 tumor cells in vitro and the kinetics of drug accumulation in the tumor in vivo were studied. Then, the effectiveness of photodynamic therapy was studied under different conditions. The maximum therapeutic effect was achieved with irradiation at 1 hour after injection of the drug.

Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental Observations and Molecular Mechanics

2020 ◽  
Vol 17 ◽  
Author(s):  
Manmeet Singh ◽  
Dilpreet Singh ◽  
Sundar Mahajan ◽  
Bilal Ahmed Sheikh ◽  
Neena Bedi
Keyword(s):  
Delivery System ◽  
Food Effect ◽  
Hydroxypropyl Methylcellulose ◽  
Hiv Treatment ◽  
Water Soluble ◽  
In Silico Docking ◽  
Precipitation Inhibitor ◽  
In Vivo Pharmacokinetics

Background: Supersaturable SMEDDS, a versatile dosage form, was investigated for improving the biopharmaceutical attributes and eradicating the food effect of poorly water soluble drug efavirenz. Objective: The present research pursues development of efavirenz loaded supersaturable self-microemulsifying drug delivery system (SS SMEDDS) for improving biopharmaceutical performance. Methods: Preformulation studies were carried out to determine the optimized range of lipid excipients to develop stable supersaturated SMEDDS (ST SMEDDS). The SS SMEDD formulation was prepared by adding hydroxypropyl methylcellulose as a polymeric precipitation inhibitor. The developed SS SMEDDS were evaluated for supersaturation behavior by performing in vitro supersaturation studies and molecular simulations by in silico docking. Dissolution was performed in biorelevant media to simulate fed/fasted conditions in gastrointestinal regions. Absorption behavior was determined through in vivo pharmacokinetics approach. Results: The optimized ST SMEDDS formulation containing Maisine® CC, Tween 80 and Transcutol-P exhibited thermodynamic stability with quick rate of emulsification. The optimized SS SMEDDS containing suitable polymeric precipitation inhibitor exhibited enhanced efavirenz concentration in in vitro supersaturation test. The theoretical simulations by molecular docking revealed strong intermolecular interactions with a docking score of -3.004 KJ/mol. The dissolution performance of marketed product in biorelevant dissolution media inferred the existence of food effect in the dissolution of efavirenz. However, in SS SMEDDS, no significant differences in drug release behavior under different fasted/fed conditions signify that the food effect was neutralized. In vivo pharmacokinetics revealed a significant increase in the absorption profile of efavirenz from SS SMEDDS than that of ST SMEDDS and marketed product. Conclusion: The designed delivery system indicated promising results in developing an effectual EFV formulation for HIV treatment.

A folic acid conjugated polyethylenimine-modified PEGylated nanographene loaded photosensitizer: photodynamic therapy and toxicity studies in vitro and in vivo

2016 ◽  
Vol 4 (12) ◽  
pp. 2190-2198 ◽  
Author(s):  
Yi-Ping Zeng ◽  
Sheng-Lin Luo ◽  
Zhang-You Yang ◽  
Jia-Wei Huang ◽  
Hong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Delivery System ◽  
Tumor Targeting ◽  
Therapy Efficacy ◽  
Toxicity Studies ◽  
Targeting Delivery

A novel nanographene-based tumor-targeting delivery system has high photodynamic therapy efficacy with no obvious toxicity and could potentially be utilized in biomedicine.

Polymer Brush-Stabilized Polyplex for a siRNA Carrier with Long Blood Circulatory Half-Life

2008 ◽  
Vol 47-50 ◽  
pp. 762-764 ◽  
Author(s):  
Arihiro Kano ◽  
Takeshi Yamano ◽  
Sun Won Choi ◽  
Atsushi Maruyama
Keyword(s):  
Delivery System ◽  
Half Life ◽  
Blood Circulation ◽  
Sirna Delivery ◽  
Polymer Brush ◽  
Water Soluble ◽  
Side Chains ◽  
Grafting Ratio ◽  
Interfering Rna

Small interfering RNA (siRNA) holds potential as a therapeutic approach to silence targeted gene of disease, but siRNA has limited stability in vivo. Therefore, delivery system of siRNA is the key to siRNA therapeutic application. We attempted to develop a delivery system, which enables siRNA to demonstrate high stability and long blood circulation. We synthesized a series of bottlebrush-type copolymers (BBCs) possessing polycationic backbone (less than 30 wt%) and abundant water-soluble side chains (more than 70 wt%) as siRNA carrier. A siRNA complexed with the BBC was resistant to nuclease and stable in plasma. Especially, the BBC (10 wt% PLL and 90 wt% PEG) having higher grafting ratio (≈ 90 wt%) of water-soluble side chains showed 100-times enhanced stability of siRNA in mouse bloodstream in vivo. Surprisingly, even when the BBC and siRNA separately injected into mouse at 20 min interval, the BBC increased blood half life of the siRNA. These results suggest that the BBC has higher selectivity in its ionic interaction to siRNA than other anionic substance in blood components. To our knowledge, this is the first report of siRNA delivery carrier which prolonged blood circulation of siRNA without resource-consuming preparation process.

A delivery system to avoid self-aggregation and to improve in vitro and in vivo skin delivery of a phthalocyanine derivative used in the photodynamic therapy

2011 ◽  
Vol 155 (3) ◽  
pp. 400-408 ◽  
Author(s):  
Fábia Cristina Rossetti ◽  
Luciana Biagini Lopes ◽  
Aline Regina H. Carollo ◽  
José A. Thomazini ◽  
Antônio Cláudio Tedesco ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Delivery System ◽  
Skin Delivery ◽  
Phthalocyanine Derivative ◽  
Self Aggregation

Self-assembly nanoparticles based on supramolecular-organic frameworks and temoporfin for an enhanced photodynamic therapy in vitro and in vivo

2022 ◽  
Author(s):  
Ziyue Xu ◽  
Weipeng Mao ◽  
Zizhen Zhao ◽  
Zekun Wang ◽  
Yue-Yang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Three Dimensional ◽  
Water Soluble ◽  
Generation Efficiency ◽  
Quenching Effect

Water-soluble three-dimensional supramolecular-organic frameworks (SOFs) and temoporfin (mTHPC) are discovered to form uniform self-assembly nanoparticles. These nanoparticles demonstrate an improved 1O2 generation efficiency due to a reduced aggregation-caused quenching effect....

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