scholarly journals Quinoline-triazole half-sandwich iridium(iii) complexes: synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies

2020 ◽  
Vol 49 (33) ◽  
pp. 11543-11555
Author(s):  
Diana R. Melis ◽  
Christopher B. Barnett ◽  
Lubbe Wiesner ◽  
Ebbe Nordlander ◽  
Gregory S. Smith
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Transfer Hydrogenation ◽  
Antiplasmodial Activity ◽  
Sandwich Complexes ◽  
Inhibitory Activities ◽  
Hybrid Ligands ◽  
Half Sandwich

Iridium(iii) half-sandwich complexes containing 7-chloroquinoline-1,2,3-triazole hybrid ligands were synthesised and their inhibitory activities evaluated against the Plasmodium falciparum malaria parasite.

N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD+

2019 ◽  
Vol 48 (35) ◽  
pp. 13143-13148 ◽  
Author(s):  
Tameryn Stringer ◽  
Diana R. Melis ◽  
Gregory S. Smith
Keyword(s):  
Plasmodium Falciparum ◽  
Transfer Hydrogenation ◽  
Antiplasmodial Activity ◽  
Preliminary Evaluation ◽  
Iridium Complexes ◽  
Drug Resistant ◽  
Hydrogenation Catalysts ◽  
Half Sandwich

Two Rh(iii) and Ir(iii) half-sandwich quinoline-based complexes were evaluated for theirin vitroantiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the parasite,Plasmodium falciparum.

scholarly journals Mutations in pfmdr1 Modulate the Sensitivity of Plasmodium falciparum to the Intrinsic Antiplasmodial Activity of Verapamil

2005 ◽  
Vol 49 (2) ◽  
pp. 840-842 ◽  
Author(s):  
Rhys Hayward ◽  
Kevin J. Saliba ◽  
Kiaran Kirk
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Antiplasmodial Activity ◽  
Chloroquine Resistance ◽  
Toxic Effects ◽  
Human Malaria Parasite ◽  
Human Malaria

ABSTRACT As well as having the ability to reverse chloroquine resistance in the human malaria parasite Plasmodium falciparum, verapamil has itself an innate antiplasmodial activity. We show here that mutations in Pgh1, the product of the malaria parasite's pfmdr1 gene, influence the parasite's susceptibility to the toxic effects of verapamil.

scholarly journals 16-Electron pentadienyl- and cyclopentadienyl-ruthenium half-sandwich complexes with bis(imidazol-2-imine) ligands and their use in catalytic transfer hydrogenation

2015 ◽  
Vol 44 (26) ◽  
pp. 11717-11724 ◽  
Author(s):  
Thomas Glöge ◽  
Kristof Jess ◽  
Thomas Bannenberg ◽  
Peter G. Jones ◽  
Nadine Langenscheidt-Dabringhausen ◽  
...  
Keyword(s):  
Ligand Exchange ◽  
Transfer Hydrogenation ◽  
Catalytic Transfer Hydrogenation ◽  
Sandwich Complexes ◽  
Hydrogenation Catalysts ◽  
Catalytic Transfer ◽  
Imine Ligands ◽  
Half Sandwich ◽  
Efficient Transfer

Ligand exchange from “protonated open ruthenocene” afforded 16-electron ruthenium half-sandwich complexes as efficient transfer hydrogenation catalysts.

Half-Sandwich Complexes of Osmium(II) withl-α-Amino Carboxylate Ligands as Asymmetric Transfer Hydrogenation Catalysts. On the Origin of the Enantioselectivity

2012 ◽  
Vol 31 (8) ◽  
pp. 3333-3345 ◽  
Author(s):  
Daniel Carmona ◽  
Fernando J. Lahoz ◽  
Pilar García-Orduña ◽  
Luis A. Oro ◽  
M. Pilar Lamata ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Sandwich Complexes ◽  
Carboxylate Ligands ◽  
Hydrogenation Catalysts ◽  
Half Sandwich
Sign in / Sign up

Export Citation Format

Share Document