Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production

2020 ◽  
Vol 49 (14) ◽  
pp. 4615-4636 ◽  
Author(s):  
Yoo-Sung Ko ◽  
Je Woong Kim ◽  
Jong An Lee ◽  
Taehee Han ◽  
Gi Bae Kim ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Microbial Cell ◽  
Chemical Production ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Systems Metabolic Engineering

This tutorial review covers tools, strategies, and procedures of systems metabolic engineering facilitating the development of microbial cell factories efficiently producing chemicals and materials.

Escherichia coli as a platform microbial host for systems metabolic engineering

2021 ◽  
Author(s):  
Dongsoo Yang ◽  
Cindy Pricilia Surya Prabowo ◽  
Hyunmin Eun ◽  
Seon Young Park ◽  
In Jin Cho ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Natural Products ◽  
Metabolic Engineering ◽  
Food Ingredients ◽  
E Coli ◽  
Renewable Biomass ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Systems Metabolic Engineering ◽  
Microbial Host

Abstract Bio-based production of industrially important chemicals and materials from non-edible and renewable biomass has become increasingly important to resolve the urgent worldwide issues including climate change. Also, bio-based production, instead of chemical synthesis, of food ingredients and natural products has gained ever increasing interest for health benefits. Systems metabolic engineering allows more efficient development of microbial cell factories capable of sustainable, green, and human-friendly production of diverse chemicals and materials. Escherichia coli is unarguably the most widely employed host strain for the bio-based production of chemicals and materials. In the present paper, we review the tools and strategies employed for systems metabolic engineering of E. coli. Next, representative examples and strategies for the production of chemicals including biofuels, bulk and specialty chemicals, and natural products are discussed, followed by discussion on materials including polyhydroxyalkanoates (PHAs), proteins, and nanomaterials. Lastly, future perspectives and challenges remaining for systems metabolic engineering of E. coli are discussed.

Metabolic engineering of ammonium release for nitrogen-fixing multispecies microbial cell-factories

2014 ◽  
Vol 23 ◽  
pp. 154-164 ◽  
Author(s):  
Juan Cesar Federico Ortiz-Marquez ◽  
Mauro Do Nascimento ◽  
Leonardo Curatti
Keyword(s):  
Metabolic Engineering ◽  
Microbial Cell ◽  
Nitrogen Fixing ◽  
Microbial Cell Factories ◽  
Cell Factories

scholarly journals Construction and optimization of microbial cell factories for sustainable production of bioactive dammarenediol-II glucosides

2019 ◽  
Vol 21 (12) ◽  
pp. 3286-3299 ◽  
Author(s):  
Zong-Feng Hu ◽  
An-Di Gu ◽  
Lan Liang ◽  
Yan Li ◽  
Ting Gong ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Industrial Production ◽  
Sustainable Production ◽  
Microbial Cell ◽  
Microbial Cell Factories ◽  
Cell Factories

A green and sustainable approach is established by metabolic engineering for industrial production of bioactive dammarenediol-II glucosides.

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