From industrial by‐products to value‐added compounds: the design of efficient microbial cell factories by coupling systems metabolic engineering and bioprocesses

2020 ◽  
Vol 14 (6) ◽  
pp. 1228-1238
Author(s):  
Albert E. T. Rangel ◽  
Jorge Mario Gómez Ramírez ◽  
Andrés Fernando González Barrios
Keyword(s):  
Metabolic Engineering ◽  
Value Added ◽  
Microbial Cell ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Systems Metabolic Engineering ◽  
By Products

Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production

2020 ◽  
Vol 49 (14) ◽  
pp. 4615-4636 ◽  
Author(s):  
Yoo-Sung Ko ◽  
Je Woong Kim ◽  
Jong An Lee ◽  
Taehee Han ◽  
Gi Bae Kim ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Microbial Cell ◽  
Chemical Production ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Systems Metabolic Engineering

This tutorial review covers tools, strategies, and procedures of systems metabolic engineering facilitating the development of microbial cell factories efficiently producing chemicals and materials.

Metabolic engineering of glycosylated polyketide biosynthesis

2018 ◽  
Vol 2 (3) ◽  
pp. 389-403 ◽  
Author(s):  
Ramesh Prasad Pandey ◽  
Prakash Parajuli ◽  
Jae Kyung Sohng
Keyword(s):  
Natural Products ◽  
Metabolic Engineering ◽  
Value Added ◽  
Chemical Diversity ◽  
Yeast Cells ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Modification Method ◽  
Post Modification ◽  
Microbial Biosynthesis

Microbial cell factories are extensively used for the biosynthesis of value-added chemicals, biopharmaceuticals, and biofuels. Microbial biosynthesis is also realistic for the production of heterologous molecules including complex natural products of plant and microbial origin. Glycosylation is a well-known post-modification method to engineer sugar-functionalized natural products. It is of particular interest to chemical biologists to increase chemical diversity of molecules. Employing the state-of-the-art systems and synthetic biology tools, a range of small to complex glycosylated natural products have been produced from microbes using a simple and sustainable fermentation approach. In this context, this review covers recent notable metabolic engineering approaches used for the biosynthesis of glycosylated plant and microbial polyketides in different microorganisms. This review article is broadly divided into two major parts. The first part is focused on the biosynthesis of glycosylated plant polyketides in prokaryotes and yeast cells, while the second part is focused on the generation of glycosylated microbial polyketides in actinomycetes.

Escherichia coli as a platform microbial host for systems metabolic engineering

2021 ◽  
Author(s):  
Dongsoo Yang ◽  
Cindy Pricilia Surya Prabowo ◽  
Hyunmin Eun ◽  
Seon Young Park ◽  
In Jin Cho ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Natural Products ◽  
Metabolic Engineering ◽  
Food Ingredients ◽  
E Coli ◽  
Renewable Biomass ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Systems Metabolic Engineering ◽  
Microbial Host

Abstract Bio-based production of industrially important chemicals and materials from non-edible and renewable biomass has become increasingly important to resolve the urgent worldwide issues including climate change. Also, bio-based production, instead of chemical synthesis, of food ingredients and natural products has gained ever increasing interest for health benefits. Systems metabolic engineering allows more efficient development of microbial cell factories capable of sustainable, green, and human-friendly production of diverse chemicals and materials. Escherichia coli is unarguably the most widely employed host strain for the bio-based production of chemicals and materials. In the present paper, we review the tools and strategies employed for systems metabolic engineering of E. coli. Next, representative examples and strategies for the production of chemicals including biofuels, bulk and specialty chemicals, and natural products are discussed, followed by discussion on materials including polyhydroxyalkanoates (PHAs), proteins, and nanomaterials. Lastly, future perspectives and challenges remaining for systems metabolic engineering of E. coli are discussed.

Metabolic engineering of ammonium release for nitrogen-fixing multispecies microbial cell-factories

2014 ◽  
Vol 23 ◽  
pp. 154-164 ◽  
Author(s):  
Juan Cesar Federico Ortiz-Marquez ◽  
Mauro Do Nascimento ◽  
Leonardo Curatti
Keyword(s):  
Metabolic Engineering ◽  
Microbial Cell ◽  
Nitrogen Fixing ◽  
Microbial Cell Factories ◽  
Cell Factories

scholarly journals Construction and optimization of microbial cell factories for sustainable production of bioactive dammarenediol-II glucosides

2019 ◽  
Vol 21 (12) ◽  
pp. 3286-3299 ◽  
Author(s):  
Zong-Feng Hu ◽  
An-Di Gu ◽  
Lan Liang ◽  
Yan Li ◽  
Ting Gong ◽  
...  
Keyword(s):  
Metabolic Engineering ◽  
Industrial Production ◽  
Sustainable Production ◽  
Microbial Cell ◽  
Microbial Cell Factories ◽  
Cell Factories

A green and sustainable approach is established by metabolic engineering for industrial production of bioactive dammarenediol-II glucosides.

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