Electric field-driven conformational changes in the elastin protein

2021 ◽  
Vol 23 (7) ◽  
pp. 4195-4204
Author(s):  
Debajyoti De ◽  
Nisha Pawar ◽  
Amar Nath Gupta
Keyword(s):  
Electric Field ◽  
Conformational Changes

Electric field masked the aggregation in elastin.

Improving the analysis of NMR spectra tracking pH-induced conformational changes: Removing artefacts of the electric field on the NMR chemical shift

2009 ◽  
Vol 78 (4) ◽  
pp. 971-984 ◽  
Author(s):  
Predrag Kukić ◽  
Damien Farrell ◽  
Chresten R. Søndergaard ◽  
Una Bjarnadottir ◽  
John Bradley ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Electric Field ◽  
Conformational Changes ◽  
Nmr Spectra ◽  
Nmr Chemical Shift

ELECTRIC-FIELD DEPENDENCE OF MOLECULAR CONFORMATIONS OBSERVED BY USING SCANNING TUNNELING MICROSCOPY

NANO ◽  
2008 ◽  
Vol 03 (02) ◽  
pp. 83-94
Author(s):  
XIAO JING MA ◽  
RUI ZHANG ◽  
YONG TAO SHEN ◽  
XIAO HUI QIU ◽  
YAN LIAN YANG ◽  
...  
Keyword(s):  
Electric Field ◽  
Scanning Tunneling Microscopy ◽  
Functional Groups ◽  
Field Dependence ◽  
Conformational Changes ◽  
Supramolecular Structures ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Molecular Conformations ◽  
Electric Field Dependence

We review the progress in observation of electrically induced conformational changes of a range of single molecules and molecular assemblies using scanning tunneling microscopy (STM). Recent results using species with optical active functional groups and supramolecular structures confirmed the previously observed effects that the cholesterol molecules with soft linkers have the conformational bistability when switching the bias polarity, while no discernable changes were observed for the mesogen molecules, containing rigid linking units. In addition, it was also observed that the linker units could have appreciable impacts on the assembling characteristics.

scholarly journals Receptor Binding Domain (RBD) Structural Susceptibility in the SARS-CoV-2 Virus Spike Protein Exposed to a Pulsed Electric Field

2021 ◽  
Vol 8 (2) ◽  
pp. 177-182
Author(s):  
D. Osorio-González ◽  
V. J. Muñiz-Orozco ◽  
C. P. González ◽  
M. Fuentes-Acosta ◽  
J. Mulia-Rodríguez ◽  
...  
Keyword(s):  
Electric Field ◽  
Receptor Binding ◽  
Conformational Changes ◽  
In Silico Analysis ◽  
Pulsed Electric Field ◽  
Binding Domain ◽  
Chemical Components ◽  
Receptor Binding Domain ◽  
Viral Inhibition ◽  
Starting Point

SARS-CoV-2 is responsible for causing the Coronavirus disease 2019 (COVID-19) pandemic, which has so far infected more than thirty million people and caused almost a million deaths. For this reason, it has been a priority to stop the transmission of the outbreak through preventive measures, such as surface disinfection, and to establish bases for the design of an effective disinfection technique without chemical components. In this study, we performed in silico analysis to identify the conformational alterations of the SARS-CoV-2 Spike Receptor Binding Domain (RBD) caused by the effect of a pulsed electric field at two different intensities. We found that both stimuli, especially the one with the highest angular frequency and amplitude, modified the electrical charge distribution in the RBD surface and the number of hydrogen bonds. Moreover, the secondary structure was significantly affected, with a decrease of the structured regions, particularly the regions with residues involved in recognizing and interacting with the receptor ACE2. Since many regions suffered conformational changes, we calculated RMSF and ΔRMSF to identify the regions and residues with larger fluctuations and higher flexibility. We found that regions conformed by 353-372, 453-464, and 470-490 amino acid residues fluctuate the most, where the first is considered a therapeutic target, and the last has alreadybeen characterized for its flexibility. Our results indicate that a pulsed electric field can cause loss of stability in the Spike-RBD, and we were able to identify the vulnerable sites to be used as a starting point for the development of viral inhibition or inactivation mechanisms.

Catalytic Mechanism of Human Ten-Eleven Translocation-2 (TET2) Enzyme: Effects of Conformational Changes, Electric Field, and Mutations

ACS Catalysis ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 3877-3890
Author(s):  
Sodiq O. Waheed ◽  
Shobhit S. Chaturvedi ◽  
Tatyana G. Karabencheva-Christova ◽  
Christo Z. Christov
Keyword(s):  
Electric Field ◽  
Conformational Changes ◽  
Catalytic Mechanism
Sign in / Sign up

Export Citation Format

Share Document