scholarly journals Amphiphilic ionic liquid induced fusion of phospholipid liposomes

2020 ◽  
Vol 22 (43) ◽  
pp. 25255-25263
Author(s):  
Sandeep Kumar ◽  
Navleen Kaur ◽  
Venus Singh Mithu
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Structural Integrity ◽  
Unilamellar Vesicles ◽  
Phospholipid Liposomes ◽  
Large Unilamellar Vesicles ◽  
The Impact

The impact of increasing concentration of imidazolium-based ionic liquids ([CnMIM]+[Br]−) on the structural integrity of large unilamellar vesicles (LUVs) made of pure phosphatidylcholine (PC) and phosphatidylglycerol (PG) lipids.

scholarly journals Amphiphilic Ionic Liquid Induced Fusion of Phospholipid Liposomes

2020 ◽  
Author(s):  
Sandeep Kumar ◽  
Navleen Kaur ◽  
Venus Singh Mithu
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Membrane Fusion ◽  
Solid State Nmr ◽  
Structural Integrity ◽  
Cellular Membrane ◽  
Phospholipid Membrane ◽  
Imidazolium Cations ◽  
Phospholipid Liposomes ◽  
Potential Applications

Membrane fusion is a key biological phenomenon with potential applications in biotechnology. In this work, we provide biophysical and structural evidence that liposomes composed of POPC/POPG phospholipids undergo fusion in the presence of ionic liquids containing 1-alkyl-3-methyl-imidazolium cations. The fusion phenomenon is confirmed using dynamic light scattering based size measurements, and Fluorescence based dye leakage and lipid mixing assays. <sup>1</sup>H-<sup>1</sup>H NOESY measurements using solid-state NMR spectroscopy were performed to obtain insights into fusion mechanism. It is found that ionic liquid induced splaying of phospholipid chains is crucial for overcoming the hydration barrier between the merging bilayers. Also, transiently lived fusion-holes are formed at the initial stages of bilayer mixing resulting in a leaky fusion phenomenon. <br><br>Although considered as “green” alternatives to conventional solvents, ionic liquids can exhibit cytotoxicity by altering the structural integrity of cellular membrane. Our study provides mechanistic details of the evolution of phospholipid membrane structure resulting in membrane fusion when subjected to increasing ionic liquid concentrations. We believe that findings of this study will further our understanding of ionic liquids induced cytotoxicity and non-protein assisted membrane fusion. <br><br>

Amphiphilic Ionic Liquid Induced Fusion of Phospholipid Liposomes

2020 ◽  
Author(s):  
Sandeep Kumar ◽  
Navleen Kaur ◽  
Venus Singh Mithu
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Membrane Fusion ◽  
Solid State Nmr ◽  
Structural Integrity ◽  
Cellular Membrane ◽  
Phospholipid Membrane ◽  
Imidazolium Cations ◽  
Phospholipid Liposomes ◽  
Potential Applications

Membrane fusion is a key biological phenomenon with potential applications in biotechnology. In this work, we provide biophysical and structural evidence that liposomes composed of POPC/POPG phospholipids undergo fusion in the presence of ionic liquids containing 1-alkyl-3-methyl-imidazolium cations. The fusion phenomenon is confirmed using dynamic light scattering based size measurements, and Fluorescence based dye leakage and lipid mixing assays. <sup>1</sup>H-<sup>1</sup>H NOESY measurements using solid-state NMR spectroscopy were performed to obtain insights into fusion mechanism. It is found that ionic liquid induced splaying of phospholipid chains is crucial for overcoming the hydration barrier between the merging bilayers. Also, transiently lived fusion-holes are formed at the initial stages of bilayer mixing resulting in a leaky fusion phenomenon. <br><br>Although considered as “green” alternatives to conventional solvents, ionic liquids can exhibit cytotoxicity by altering the structural integrity of cellular membrane. Our study provides mechanistic details of the evolution of phospholipid membrane structure resulting in membrane fusion when subjected to increasing ionic liquid concentrations. We believe that findings of this study will further our understanding of ionic liquids induced cytotoxicity and non-protein assisted membrane fusion. <br><br>

scholarly journals Controlled Nanostructuration of Cobalt Oxyhydroxide Electrode Material for Hybrid Supercapacitors

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2325
Author(s):  
Ronan Invernizzi ◽  
Liliane Guerlou-Demourgues ◽  
François Weill ◽  
Alexia Lemoine ◽  
Marie-Anne Dourges ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Energy Storage ◽  
Specific Surface ◽  
Electrode Materials ◽  
Specific Capacity ◽  
Hybrid Supercapacitors ◽  
Cobalt Oxyhydroxide ◽  
Precipitation Medium ◽  
The Impact

Nanostructuration is one of the most promising strategies to develop performant electrode materials for energy storage devices, such as hybrid supercapacitors. In this work, we studied the influence of precipitation medium and the use of a series of 1-alkyl-3-methylimidazolium bromide ionic liquids for the nanostructuration of β(III) cobalt oxyhydroxides. Then, the effect of the nanostructuration and the impact of the different ionic liquids used during synthesis were investigated in terms of energy storage performances. First, we demonstrated that forward precipitation, in a cobalt-rich medium, leads to smaller particles with higher specific surface areas (SSA) and an enhanced mesoporosity. Introduction of ionic liquids (ILs) in the precipitation medium further strongly increased the specific surface area and the mesoporosity to achieve well-nanostructured materials with a very high SSA of 265 m2/g and porosity of 0.43 cm3/g. Additionally, we showed that ILs used as surfactant and template also functionalize the nanomaterial surface, leading to a beneficial synergy between the highly ionic conductive IL and the cobalt oxyhydroxide, which lowers the resistance charge transfer and improves the specific capacity. The nature of the ionic liquid had an important influence on the final electrochemical properties and the best performances were reached with the ionic liquid containing the longest alkyl chain.

scholarly journals The impact of ionic liquid fluorinated moieties on their thermophysical properties and aqueous phase behaviour

2014 ◽  
Vol 16 (39) ◽  
pp. 21340-21348 ◽  
Author(s):  
Catarina M. S. S. Neves ◽  
Kiki A. Kurnia ◽  
Karina Shimizu ◽  
Isabel M. Marrucho ◽  
Luís Paulo N. Rebelo ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Aqueous Phase ◽  
Thermophysical Properties ◽  
Phase Behaviour ◽  
Alkyl Chains ◽  
The Impact

The presence of fluorinated alkyl chains in ionic liquids is quite relevant regarding their thermophysical properties and aqueous phase behaviour.

Role of Cation in Enhancing the Conversion of the Alzheimer’s Peptide into Amyloid Fibrils Using Protic Ionic Liquids

2012 ◽  
Vol 65 (11) ◽  
pp. 1502 ◽  
Author(s):  
Natalie Debeljuh ◽  
Swapna Varghese ◽  
Colin J. Barrow ◽  
Nolene Byrne
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Primary Amine ◽  
Amyloid Fibrils ◽  
Tertiary Amines ◽  
Protic Ionic Liquids ◽  
Protic Ionic Liquid ◽  
The Difference ◽  
The Impact

We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the Aβ 16–22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.

scholarly journals Computational solvation analysis of biomolecules in aqueous ionic liquid mixtures

2018 ◽  
Vol 10 (3) ◽  
pp. 825-840 ◽  
Author(s):  
Veronika Zeindlhofer ◽  
Christian Schröder
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Liquid Mixtures ◽  
High Viscosity ◽  
Full Potential ◽  
New Class ◽  
Fundamental Knowledge ◽  
Structure And Dynamics ◽  
Significant Interest ◽  
The Impact

Abstract Based on their tunable properties, ionic liquids attracted significant interest to replace conventional, organic solvents in biomolecular applications. Following a Gartner cycle, the expectations on this new class of solvents dropped after the initial hype due to the high viscosity, hydrolysis, and toxicity problems as well as their high cost. Since not all possible combinations of cations and anions can be tested experimentally, fundamental knowledge on the interaction of the ionic liquid ions with water and with biomolecules is mandatory to optimize the solvation behavior, the biodegradability, and the costs of the ionic liquid. Here, we report on current computational approaches to characterize the impact of the ionic liquid ions on the structure and dynamics of the biomolecule and its solvation layer to explore the full potential of ionic liquids.

scholarly journals Impact of ionic liquids on absorption behaviour of natural fibers/biopolyethylene biocomposites

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joanna Rakowska ◽  
Magdalena Węgrzyn ◽  
Ewa Rudnik
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Flame Retardants ◽  
Moisture Absorption ◽  
Raw Materials ◽  
Natural Fibers ◽  
Absorption Properties ◽  
Plant Fibers ◽  
Hemp Fibers ◽  
The Impact

AbstractFor many years, there has been a growing interest in technologies enabling the replacement of conventional polymer composites with new materials made from renewable raw materials. It is important to assess the behaviour of biocomposites in various environments, including humid conditions. Recently, ionic liquids have been studied as potential modificators of polymers properties, especially flame retardants. In previous study the impact of ionic liquids on thermal and mechanical properties of biocomposites was assessed. In this study the influence of ionic liquids on moisture absorption properties of biocomposites at different relative humidities (RH) was assessed. The biocomposites were built from polyethylene from renewable resources reinforced with flax or hemp fibers. The effect of the addition of 0.5, 1.0, 2.5 and 5 wt.% phosphonium ionic liquids on the moisture absorption properties of biopolyethylene biocomposite reinforced with natural fibers were tested. Mixtures of biopolyethylene, natural fibers and ionic liquid were calendered at 180 °C and then were compounded by injection moulding. The prepared samples were then characterized for their moisture uptake at 30%, 50% and 100% RH. Moisture absorption by biocomposites depended on the structure of the ionic liquid and the type of fiber. The saturation of moisture of about 0.054% was found for samples modified with tributylethylphosphonium diethyl phosphate and reinforced with flax and hemp fibers at RH 100%. The environmental resistance of the materials was found to be improved after the addition of trihexyltetradecylphosphonium bis (2,4,4-trimethylpentyl) phosphinate. Biocomposites with hemp fibers showed slightly less absorption than with flax fibers. It was also observed that ionic liquids: (bis (2,4,4-trimethylpentyl) phosphinate trihexyltetradecylphosphonate) and (bis (2-ethylhexyl) trihexyltetradecylphosphonium phosphate) protect PE biocomposites with plant fibers against mold in high humidity conditions (RH 100%).

scholarly journals Analysis of Sustainable Methods to Recover Neodymium

2021 ◽  
Vol 2 (3) ◽  
pp. 550-563
Author(s):  
Kalani Periyapperuma ◽  
Laura Sanchez-Cupido ◽  
Jennifer M. Pringle ◽  
Cristina Pozo-Gonzalo
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Permanent Magnets ◽  
Hard Disk Drives ◽  
Rechargeable Batteries ◽  
Green Energy ◽  
Special Focus ◽  
Nickel Metal ◽  
Nickel Metal Hydride ◽  
The Impact

Neodymium (Nd) is one of the most essential rare-earth metals due to its outstanding properties and crucial role in green energy technologies such as wind turbines and electric vehicles. Some of the key uses includes permanent magnets present in technological applications such as mobile phones and hard disk drives, and in nickel metal hydride batteries. Nd demand is continually growing, but reserves are severely limited, which has put its continued availability at risk. Nd recovery from end-of-life products is one of the most interesting ways to tackle the availability challenge. This perspective concentrates on the different methods to recover Nd from permanent magnets and rechargeable batteries, covering the most developed processes, hydrometallurgy and pyrometallurgy, and with a special focus on electrodeposition using highly electrochemical stable media (e.g., ionic liquids). Among all the ionic liquid chemistries, only phosphonium ionic liquids have been studied in-depth, exploring the impact of temperature, electrodeposition potential, salt concentration, additives (e.g., water) and solvation on the electrodeposition quality and quantity. Finally, the importance of investigating new ionic liquid chemistries, as well as the effect of other metal impurities in the ionic liquid on the deposit composition or the stability of the ionic liquids are discussed. This points to important directions for future work in the field to achieve the important goal of efficient and selective Nd recovery to overcome the increasingly critical supply problems.

scholarly journals Quaternary ammonium and phosphonium based ionic liquids: a comparison of common anions

2014 ◽  
Vol 16 (29) ◽  
pp. 15278-15288 ◽  
Author(s):  
Rebecca K. Blundell ◽  
Peter Licence
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Quaternary Ammonium ◽  
Electronic Environment ◽  
The Impact

The impact of changing the cationic core, from nitrogen to phosphorus upon the electronic environment of the ionic liquid is investigated with XPS.

Mapping the “Extra Solvent Power, ESP” of Ionic Liquids for Monomers, Polymers and Globular Nanoparticles

2017 ◽  
Author(s):  
Jose A. Pomposo
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Linear Polymers ◽  
Green Solvents ◽  
Ionic Polymers ◽  
First Time ◽  
Solvent Power

Understanding the miscibility behavior of ionic liquid (IL) / monomer, IL / polymer and IL / nanoparticle mixtures is critical for the use of ILs as green solvents in polymerization processes, and to rationalize recent observations concerning the superior solubility of some proteins in ILs when compared to standard solvents. In this work, the most relevant results obtained in terms of a three-component Flory-Huggins theory concerning the “Extra Solvent Power, ESP” of ILs when compared to traditional non-ionic solvents for monomeric solutes (case I), linear polymers (case II) and globular nanoparticles (case III) are presented. Moreover, useful ESP maps are drawn for the first time for IL mixtures corresponding to case I, II and III. Finally, a potential pathway to improve the miscibility of non-ionic polymers in ILs is also proposed.

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