Gold nanoplates with superb photothermal efficiency and peroxidase-like activity for rapid and synergistic antibacterial therapy

2021 ◽  
Author(s):  
Lu Yan ◽  
Jie Mu ◽  
Pengxin Ma ◽  
Qian Li ◽  
Pengxue Yin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Conversion Efficiency ◽  
Antibacterial Therapy ◽  
Infected Wound ◽  
Photothermal Conversion ◽  
Antibacterial Ability

Gold nanoplates exhibit 68.5% photothermal conversion efficiency and peroxidase-like activity, and AuNPTs (50 μg mL−1)/H2O2 (0.1 mM)/NIR (1 W cm−2, 3 min) show excellent synergistic antibacterial ability and promote MRSA-infected wound healing in vivo.

scholarly journals Complementary Effect of Non-Persistent Silver Nano-Architectures and Chlorhexidine on Infected Wound Healing

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1215
Author(s):  
Mykola Pernakov ◽  
Maria Laura Ermini ◽  
Oksana Sulaieva ◽  
Domenico Cassano ◽  
Marco Santucci ◽  
...  
Keyword(s):  
Wound Healing ◽  
Infected Wound ◽  
Bacterial Strains ◽  
Efficacy Evaluation ◽  
Complementary Effect ◽  
Macrophages Polarization ◽  
Bacteriological Profile ◽  
Purulent Wound ◽  
The Common

Surgical site infection (SSI) substantially contributes each year to patients’ morbidity and mortality, accounting for about 15% of all nosocomial infections. SSI drastically increases the rehab stint and expenses while jeopardizing health outcomes. Besides prevention, the treatment regime relies on an adequate antibiotic therapy. On the other hand, resistant bacterial strains have currently reached up to 34.3% of the total infections, and this percentage grows annually, reducing the efficacy of the common treatment schemes. Thus, new antibacterial strategies are urgently demanded. Here, we demonstrated in rats the effectiveness of non-persistent silver nano-architectures (AgNAs) in infected wound healing together with their synergistic action in combination with chlorhexidine. Besides the in vivo efficacy evaluation, we performed analysis of the bacteriological profile of purulent wound, histological evaluations, and macrophages polarization quantifications to further validate our findings and elucidate the possible mechanisms of AgNAs action on wound healing. These findings open the way for the composition of robust multifunctional nanoplatforms for the translation of safe and efficient topical treatments of SSI.

Simple synthesis of multifunctional photosensitizers for mitochondrial and bacterial imaging and photodynamic anticancer and antibacterial therapy

2020 ◽  
Vol 8 (39) ◽  
pp. 9035-9042
Author(s):  
Ming-Yu Wu ◽  
Li Liu ◽  
Qian Zou ◽  
Jong-Kai Leung ◽  
Jia-Li Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Therapy ◽  
Healing Process ◽  
Simple Synthesis ◽  
Wound Healing Process

An isoquinolinium-based photosensitizer was developed for mitochondrial and bacterial imaging, and used in photodynamic anticancer and antibacterial therapy in a wound healing process in vivo.

Multifunctional Cu–Ag2S nanoparticles with high photothermal conversion efficiency for photoacoustic imaging-guided photothermal therapy in vivo

Nanoscale ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 825-831 ◽  
Author(s):  
Lile Dong ◽  
Guanming Ji ◽  
Yu Liu ◽  
Xia Xu ◽  
Pengpeng Lei ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
The Novel ◽  
Photothermal Conversion ◽  
Ag2s Nanoparticles

The novel Cu–Ag2S/PVP NPs with high photothermal conversion efficiency could be employed as effective photoacoustic imaging guided photothermal therapy agents.

A cationic conjugated polymer with high 808 nm NIR-triggered photothermal conversion for antibacterial treatment

2021 ◽  
Author(s):  
Chen Zhang ◽  
Kaige Wang ◽  
Xueyuan Guo ◽  
Yanli Tang
Keyword(s):  
Conversion Efficiency ◽  
Conjugated Polymer ◽  
Antibacterial Treatment ◽  
Water Soluble ◽  
Photothermal Conversion ◽  
Antibacterial Ability

A cationic water-soluble conjugated polymer with a D–A structure demonstrated high photothermal conversion efficiency and effective antibacterial ability under 808 nm irradiation.

Interlayer expansion of 2D MoS2 nanosheets for highly improved photothermal therapy of tumors in vitro and in vivo

2018 ◽  
Vol 54 (99) ◽  
pp. 13989-13992 ◽  
Author(s):  
Changhui Fu ◽  
Longfei Tan ◽  
Xiangling Ren ◽  
Qiong Wu ◽  
Haibo Shao ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Mos2 Nanosheets ◽  
Photothermal Conversion ◽  
A Value

Interlayer-expanded MoS2 nanosheets with a value of 0.94 nm are demonstrated to show a high photothermal conversion efficiency of ∼62%.

Polymyxin B-functionalized phthalocyanine for chemo-photodynamic antibacterial therapy in enhanced wound healing

2021 ◽  
Author(s):  
Lin Mei ◽  
Zhenlong Xu ◽  
Zhiqiang Miao ◽  
Mengyao Yun ◽  
Yidan Luan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Therapy ◽  
Antimicrobial Therapy ◽  
Antibacterial Agent ◽  
Polymyxin B ◽  
Infected Wound ◽  
Rapid Healing ◽  
Photodynamic Antimicrobial Therapy

This paper proposes a synergistic photodynamic antimicrobial therapy and chemotherapy for enhanced wound healing by polymyxin B-functionalized phthalocyanine (Pc-PB) as a new photosensitive antibacterial agent. Rapid healing of bacteria-infected wound...

scholarly journals In Vivo Assessments of Minocycline combined Hyaluronic Acid-mediated Ultrasound Therapy of Infected Wound in Rats

2018 ◽  
Author(s):  
Hongbo Zhang ◽  
Deshu Zhuang
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Hyaluronic Acid ◽  
Visual Inspection ◽  
Control Group ◽  
Ultrasound Therapy ◽  
Infected Wound ◽  
Hematoxylin And Eosin ◽  
Skin Scar

AbstractObjectivesThe purpose of our research was to examine the effects of Minocycline combined hyaluronic acid (HA)-mediated Ultrasound therapy of infected wound in wister rats.Methods40 female wister rats were made wound on the two side of the backbone, then infected in Staphylococcus aureus at the comic for three times. then, they are divided into four groups: control group, minocycline combined HA alone, ultasound alone, minocycline combined HA-mediated ultasound group, respective. After 3 times of treatments, the rats were killed and made into specimens. Assessments consisted of visual inspection in the change of the skin, scar formation pathological morphology by hematoxylin and eosin(HE) stain with optical microscopy, IL-1B assaying and TNF-a were performed.ResultCompared with control group, minocycline combined HA alone, ultasound alone, minocycline combined HA-mediated ultasound group all have effect for wound healing, there was a obvious improvement in all parameters over the duration of the experiment(P<0.05). Compared with the control group, minocycline combined HA-mediated ultasound group indicated less inflammation cells (P<0.001) and the reduce of and IL-1B and TNF-a (P<0.001).ConclusionMinocycline combined HA-mediated ultrasound can accelerate tissue regrowth, which exert significant benefits in healing the wounds.

Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

2019 ◽  
Vol 7 (14) ◽  
pp. 2247-2251 ◽  
Author(s):  
Lu Li ◽  
Qingzhu Yang ◽  
Lei Shi ◽  
Nannan Zheng ◽  
Zeyu Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Photothermal Conversion ◽  
Phthalocyanine Molecule

Novel phthalocyanine molecule 4OCSPC with deep NIR absorbance showed excellent photothermal therapy property for cancer cells.

scholarly journals Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tian-Long Wang ◽  
Zi-Fei Zhou ◽  
Jun-Feng Liu ◽  
Xiao-Dong Hou ◽  
Zhi Zhou ◽  
...  
Keyword(s):  
Wound Healing ◽  
Nicotinic Acid ◽  
Skin Wound ◽  
Elastic Fibers ◽  
Solvothermal Reaction ◽  
Skin Wound Healing ◽  
Antibacterial Ability ◽  
Skin Ulcers ◽  
Chronic Skin

Abstract Background Skin injury and the resultant defects are common clinical problems, and usually lead to chronic skin ulcers and even life-threatening diseases. Copper, an essential trace element of human body, has been reported to promote the regeneration of skin by stimulating proliferation of endothelial cell and enhance angiogenesis. Results Herein, we have prepared a new donut-like metal–organic frameworks (MOF) of copper-nicotinic acid (CuNA) by a simple solvothermal reaction. The rough surface of CuNA is beneficial for loading/release basic fibroblast growth factor (bFGF). The CuNAs with/without bFGF are easily processed into a light-responsive composite hydrogel with GelMA, which not only show excellent mechanical properties, but also display superior biocompatibility, antibacterial ability and bioactivity. Moreover, in the in vivo full-thickness defect model of skin wound, the resultant CuNA-bFGF@GelMA hydrogels significantly accelerate the wound healing, by simultaneously inhibiting the inflammatory response, promoting the new blood vessels formation and the deposition of collagen and elastic fibers. Conclusions Considering the superior biocompatibility, antibacterial ability and bioactivity, the CuNA and its composite light-responsive hydrogel system will be promising in the applications of skin and even other tissue regeneration. Graphic abstract

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