Interlayer expansion of 2D MoS2 nanosheets for highly improved photothermal therapy of tumors in vitro and in vivo

2018 ◽  
Vol 54 (99) ◽  
pp. 13989-13992 ◽  
Author(s):  
Changhui Fu ◽  
Longfei Tan ◽  
Xiangling Ren ◽  
Qiong Wu ◽  
Haibo Shao ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Mos2 Nanosheets ◽  
Photothermal Conversion ◽  
A Value

Interlayer-expanded MoS2 nanosheets with a value of 0.94 nm are demonstrated to show a high photothermal conversion efficiency of ∼62%.

Multifunctional Cu–Ag2S nanoparticles with high photothermal conversion efficiency for photoacoustic imaging-guided photothermal therapy in vivo

Nanoscale ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 825-831 ◽  
Author(s):  
Lile Dong ◽  
Guanming Ji ◽  
Yu Liu ◽  
Xia Xu ◽  
Pengpeng Lei ◽  
...  
Keyword(s):  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
The Novel ◽  
Photothermal Conversion ◽  
Ag2s Nanoparticles

The novel Cu–Ag2S/PVP NPs with high photothermal conversion efficiency could be employed as effective photoacoustic imaging guided photothermal therapy agents.

Novel phthalocyanine-based polymeric micelles with high near-infrared photothermal conversion efficiency under 808 nm laser irradiation for in vivo cancer therapy

2019 ◽  
Vol 7 (14) ◽  
pp. 2247-2251 ◽  
Author(s):  
Lu Li ◽  
Qingzhu Yang ◽  
Lei Shi ◽  
Nannan Zheng ◽  
Zeyu Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Photothermal Conversion ◽  
Phthalocyanine Molecule

Novel phthalocyanine molecule 4OCSPC with deep NIR absorbance showed excellent photothermal therapy property for cancer cells.

scholarly journals A Semimetal-Like Molybdenum Carbide Quantum Dots Photoacoustic Imaging and Photothermal Agent with High Photothermal Conversion Efficiency

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1776 ◽  
Author(s):  
Wenhao Dai ◽  
Haifeng Dong ◽  
Xueji Zhang
Keyword(s):  
Quantum Dots ◽  
Conversion Efficiency ◽  
Molybdenum Carbide ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Therapeutic Interventions ◽  
High Concentration ◽  
Photothermal Conversion

Theranostic platforms integrating imaging diagnostic and therapeutic interventions into a single nanoplatform have attracted considerable attention for cancer-individualized therapies. However, their uncertain stability, complex pharmacokinetics, and intrinsic toxicology of multiple components hinder their practical application in clinical research. In this paper, stable and high-concentration molybdenum carbide quantum dots (Mo2C QDs) with a diameter of approximately 6 nm and a topographic height of about 1.5 nm were synthesized using a facile sonication-assisted liquid-phase exfoliation approach. The prepared Mo2C QDs exhibited a strong near-infrared (NIR) absorbance with a high molar extinction coefficient of 4.424 Lg−1cm−1 at 808 nm, a high photothermal conversion efficiency of 42.9%, and showed excellent performance on photoacoustic imaging. The Mo2C QDs had high stability and highly biocompatibility, with low cytotoxicity. Under NIR irradiation, a remarkable in vitro and in vivo therapeutic effect was obtained. Such a stable and biocompatible all-in-one theranostic nanoagent generated by facile synthesis that combines promising imaging guidance and effective tumor ablation properties may hold great potential for theranostic nanomedicine.

Comparison of Gold Nanospheres, Nanorods, Nanocages and Nanoflowers for Combined Photothermal-Radiotherapy of Cancer

NANO ◽  
2021 ◽  
pp. 2150037
Author(s):  
Lijie Yang ◽  
Jinhua Wang ◽  
Liying Sun ◽  
Yisi Zhang ◽  
Peng Huang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Conversion Efficiency ◽  
Near Infrared ◽  
Enhancement Effect ◽  
Gold Nanospheres ◽  
Photothermal Conversion ◽  
Uptake Efficiency ◽  
Gold Nanoflowers

Gold nanoparticles are promising dual agents for combined photothermal-radiotherapy of cancer. Nevertheless, the shape effects of gold nanoparticles on photothermal conversion efficiency and radiosensitization have not been completely revealed. To address this knowledge gap, different shapes of gold nanoparticles including gold nanospheres (GNSs), gold nanorods (GNRs), gold nanocages (GNCs) and gold nanoflowers (GNFs) were synthesized. Despite being subjected to the same modification with poly (ethylene glycol) (PEG), these gold nanoparticles showed different cellular uptake efficiencies: GNFs[Formula: see text][Formula: see text][Formula: see text]GNSs[Formula: see text][Formula: see text][Formula: see text]GNCs[Formula: see text][Formula: see text][Formula: see text]GNRs. Moreover, GNRs, GNCs and GNFs could convert near-infrared (NIR) light to heat and GNFs displayed the highest photothermal conversion efficiency, whereas GNSs showed poor photothermal effects due to the weak NIR absorption. The highest uptake efficiency as well as the best photothermal conversion ability led to GNFs to exhibit the best photothermal therapeutic effect. Furthermore, all the gold nanoparticles could be used as radiosensitizers to improve radiotherapeutic effect. Among these nanoparticles, GNFs showed the best radiation enhancement effect because of their highest uptake efficiency. Furthermore, a higher accumulation of GNFs in tumor tissues was observed than those of other shaped gold nanoparticles. Importantly, our in vitro and in vivo comparative studies revealed that GNFs possessed the strongest anticancer effect in combined photothermal-radiotherapy. Hence, compared to gold nanoparticles with other shapes, the GNFs might be more desirable dual agents for highly efficient combined photothermal-radiotherapy.

scholarly journals Characterization of the SARS-CoV-2 coronavirus X4-like accessory protein

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Olanrewaju Ayodeji Durojaye ◽  
Nkwachukwu Oziamara Okoro ◽  
Arome Solomon Odiba
Keyword(s):  
Rapid Development ◽  
Protein A ◽  
The Novel ◽  
Quality Model ◽  
A Value ◽  
Model Protein ◽  
Novel Coronavirus ◽  
Global Threat

Abstract Background The novel coronavirus SARS-CoV-2 is currently a global threat to health and economies. Therapeutics and vaccines are in rapid development; however, none of these therapeutics are considered as absolute cure, and the potential to mutate makes it necessary to find therapeutics that target a highly conserved regions of the viral structure. Results In this study, we characterized an essential but poorly understood coronavirus accessory X4 protein, a core and stable component of the SARS-CoV family. Sequence analysis shows a conserved ~ 90% identity between the SARS-CoV-2 and previously characterized X4 protein in the database. QMEAN Z score of the model protein shows a value of around 0.5, within the acceptable range 0–1. A MolProbity score of 2.96 was obtained for the model protein and indicates a good quality model. The model has Ramachandran values of φ = − 57o and ψ = − 47o for α-helices and values of φ = − 130o and ψ = + 140o for twisted sheets. Conclusions The protein data obtained from this study provides robust information for further in vitro and in vivo experiment, targeted at devising therapeutics against the virus. Phylogenetic analysis further supports previous evidence that the SARS-CoV-2 is positioned with the SL-CoVZC45, BtRs-BetaCoV/YN2018B and the RS4231 Bat SARS-like corona viruses.

Effects of hypercapnia on ECoG and oxidative metabolism in neonatal dog brain

1995 ◽  
Vol 78 (6) ◽  
pp. 2272-2278 ◽  
Author(s):  
H. Yoshioka ◽  
H. Miyake ◽  
D. S. Smith ◽  
B. Chance ◽  
T. Sawada ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Resonance Spectroscopy ◽  
Respiratory Enzymes ◽  
Arterial Pco2 ◽  
A Value ◽  
Electrocorticogram Ecog ◽  
The Brain ◽  
Mitochondrial Respiratory

The effects of hypercapnia on cerebral electrical activity and mitochondrial oxidative phosphorylation were studied in the anesthetized neonatal dog by using the electrocorticogram (ECoG) and 31P-magnetic resonance spectroscopy. Three levels of hypercapnia with arterial PCO2 values of approximately 70, 100, and 140 Torr reduced the intracellular pH of the brain from 7.11 to 6.99, 6.87, and 6.76, respectively. These levels of hypercapnia also reduced ADP concentration ([ADP]) from 21.5 to 18.1, 14.8, and 12.9 microM as well as the average ECoG power output by 20, 30, and 40%. A Michaelis-Menten relationship for the mitochondrial respiratory enzymes was fitted with [ADP] and the change in the average ECoG. The result suggests that mitochondrial respiration is regulated by [ADP] and that the in vivo Michaelis-Menten constant for ADP was 21 microM, a value close to the in vitro value. The mitochondrial maximal reaction velocity was reduced by only 10% during hypercapnia and showed no relationship with the degree of acidosis, suggesting that mitochondrial respiratory enzymes are not responsible for the inhibition of the brain electrical activity.

scholarly journals Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy

2021 ◽  
Vol 22 (22) ◽  
pp. 12214
Author(s):  
Cheng-Liang Peng ◽  
Ying-Hsia Shih ◽  
Ping-Fang Chiang ◽  
Chun-Tang Chen ◽  
Ming-Cheng Chang
Keyword(s):  
Photothermal Therapy ◽  
Radionuclide Therapy ◽  
Nuclear Imaging ◽  
Biological Evaluation ◽  
Targeted Radionuclide Therapy ◽  
Nir Fluorescence ◽  
Tumor Accumulation ◽  
Selective Accumulation

Cancer is one of the leading causes of death in the world. A cancer-targeted multifunctional probe labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging (PET, SPECT), for photothermal therapy (PTT), and targeted radionuclide therapy of cancer. In this study, synthesis, characterization, in vitro, and in vivo biological evaluation of the cyanine-based probe (DOTA-NIR790) were demonstrated. The use of cyanine dyes for the selective accumulation of cancer cells were used to achieve the characteristics of tumor markers. Therefore, all kinds of organ tumors can be targeted for diagnosis and treatment. The DOTA-NIR790 labeled with lutetium-111 could detect original or metastatic tumors by using SPECT imaging and quantify tumor accumulation. The β-emission of 177Lu-DOTA-NIR790 can be used for targeted radionuclide therapy of tumors. The DOTA-NIR790 enabled imaging by NIR fluorescence and by nuclear imaging (SPECT) to monitor in real-time the tumor accumulation and the situation of cancer therapy, and to guide the surgery or the photothermal therapy of the tumor. The radionuclide-labeled heptamethine cyanine based probe (DOTA-NIR790) offers multifunctional modalities for imaging and therapies of cancer.

Bi2 S3 -Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo

2018 ◽  
Vol 7 (22) ◽  
pp. 1800830 ◽  
Author(s):  
Li Song ◽  
Xinghua Dong ◽  
Shuang Zhu ◽  
Chunfang Zhang ◽  
Wenyan Yin ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Pi3k Inhibitor ◽  
Tween 20 ◽  
Pi3k Inhibitor Ly294002 ◽  
Lovo Cells

A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

2021 ◽  
Vol 16 (7) ◽  
pp. 1029-1036
Author(s):  
Hongzhu Wang ◽  
Mengxun Chen ◽  
Liping Song ◽  
Youju Huang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

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