Design of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin via iridium-catalyzed asymmetric hydrogenation

2021 ◽  
Vol 57 (2) ◽  
pp. 195-198
Author(s):  
Xiang-Yu Ye ◽  
Zhi-Qin Liang ◽  
Cong Jin ◽  
Qi-Wei Lang ◽  
Gen-Qiang Chen ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Hydrogenation ◽  
High Reactivity ◽  
Iridium Complexes ◽  
Oxazoline Ligands

A series of highly rigid oxa-spiro phosphine–oxazoline ligands (O-SIPHOX) were synthesized efficiently, their iridium complexes showed high reactivity and enantioselectivity in the synthesis of key intermediate of anti-obesity drug lorcaserin.

Iridium Complexes with Phosphine−Phosphite Ligands. Structural Aspects and Application in the Catalytic Asymmetric Hydrogenation of N-Aryl Imines

2006 ◽  
Vol 25 (4) ◽  
pp. 961-973 ◽  
Author(s):  
Sergio Vargas ◽  
Miguel Rubio ◽  
Andrés Suárez ◽  
Diego del Río ◽  
Eleuterio Álvarez ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Iridium Complexes ◽  
Phosphite Ligands ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Hydrogenation ◽  
Structural Aspects

ChemInform Abstract: Iridium-Catalyzed Asymmetric Hydrogenation of Olefins Using TIQ Phosphine-Oxazoline Ligands.

ChemInform ◽  
2011 ◽  
Vol 42 (7) ◽  
pp. no-no
Author(s):  
Sai Kumar Chakka ◽  
Byron K. Peters ◽  
Pher G. Andersson ◽  
Glenn E. M. Maguire ◽  
Hendrik G. Kruger ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Oxazoline Ligands
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