Biological applications of synthetic anion transporters

2020 ◽  
Vol 56 (91) ◽  
pp. 14137-14153 ◽  
Author(s):  
Nasim Akhtar ◽  
Oindrila Biswas ◽  
Debasis Manna
Keyword(s):  
Small Molecules ◽  
Cancer Cells ◽  
Transmembrane Transport ◽  
Biological Applications ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Anion Transporters

Transmembrane transport of anions by small molecules has recently been used to reduce the viability of cancer cells and fight against antibiotic-resistant and clinically relevant bacterial strains.

scholarly journals Small molecule anion transporters display in vitro antimicrobial activity against clinically relevant bacterial strains

2019 ◽  
Vol 55 (68) ◽  
pp. 10080-10083 ◽  
Author(s):  
Israel Carreira-Barral ◽  
Carlos Rumbo ◽  
Marcin Mielczarek ◽  
Daniel Alonso-Carrillo ◽  
Enara Herran ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Small Molecule ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
In Vitro Antimicrobial Activity ◽  
Anion Transporters ◽  
Highly Active

Highly active transmembrane anion transporters have demonstrated their activity against antibiotic-resistant and clinically relevant bacterial strains.

scholarly journals Development of Effective Antibacterial Treatment: Lessons from the Past and Novel Approaches

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 230
Author(s):  
Mariagrazia Di Luca ◽  
Tiziano Marzo
Keyword(s):  
Antibacterial Treatment ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
The Past ◽  
Novel Approaches ◽  
Rapid Diffusion

In the last three decades, the appearance and rapid diffusion of antibiotic-resistant bacterial strains have been observed [...]

scholarly journals 1564. Activity of bacteriophage against multidrug resistant Klebsiella pneumoniae

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S782-S782
Author(s):  
Sailaja Puttagunta ◽  
Maya Kahan-Haanum ◽  
Sharon Kredo-Russo ◽  
Eyal Weinstock ◽  
Efrat Khabra ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Unmet Need ◽  
Multidrug Resistant ◽  
Beta Lactamase ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Extended Spectrum Beta Lactamase ◽  
Novel Approach ◽  
Infection Types

Abstract Background The prevalence of extended-spectrum beta-lactamase (ESBL) producing and carbapenem resistant (CR) Klebsiella pneumoniae (KP) has significantly risen in all geographic regions. Infections due to these bacteria are associated with high mortality across different infection types. Even with newer options, there remains an unmet need for safe and effective therapeutic options to treat infections caused by ESBL and CR KP. Phage therapy offers a novel approach with an unprecedented and orthogonal mechanism of action for treatment of diseases caused by pathogenic bacterial strains that are insufficiently addressed by available antibiotics. Phage-based therapies confer a high strain-level specificity and have a strong intrinsic safety profile. Here we describe the identification of novel phages that can effectively target antibiotic resistant KP strains. Host range of the 21 phages on 33 strain KP panel via solid culture infectivity assays. Red marks resistance to infection while sensitivity to phage is marked in green Methods KP clinical strains were isolated from human stool specimens preserved in glycerol. Selective culturing was carried, followed by testing of individual colonies for motility, indole and urease production, sequenced and analyzed by Kleborate tool to determine antibiotic resistant genes. Natural phages were isolated from plaques that developed on susceptible bacterial targets, sequenced and characterized. Results Antibiotic-resistant KP strains encoding beta lactamase genes or a carbapenemase (n=33) were isolated from healthy individuals (n=3), and patients with inflammatory bowel disease (n=26) or primary sclerosing cholangitis (n=3). Isolates sequencing revealed bla CTX-M15 and/or bla SHV encoding strains and carbapenamase KPC-2. A panel of 21 phages targeting the beta-lactamase- and carbapenemase-producing KP strains were identified. Phage sequencing revealed that all phages belong to the Caudovirales order and include 6 Siphoviridae, 14 Myoviridae, and 1 Podoviridae. In vitro lytic activity of the phages was tested on the isolated bacteria and revealed a coverage of 70% of the 33 isolated antibiotic resistant strains, >50% of which were targeted by multiple phages. Conclusion Collectively, these results demonstrate the feasibility of identifying phage with potent activity against antibiotic resistant KP strains, and may provide a novel therapeutic approach for treatment of ESBL and CR KP infections. Disclosures All Authors: No reported disclosures

Structural Insights into the Recognition of DNA Defects by Small Molecules

2021 ◽  
Author(s):  
David Dayanidhi Paul Elisa Sundar ◽  
Vaidyanathan Ganesan
Keyword(s):  
Nucleic Acids ◽  
Metal Complexes ◽  
Small Molecules ◽  
Chemical Properties ◽  
Biological Applications ◽  
Binding Interaction ◽  
Structural Insights

Studies on the binding interaction of small molecules and nucleic acids have been explored for their biological applications. With excellent photophysical/chemical properties, numerous metal complexes have been studied as structural...

scholarly journals Polymeric Systems as Antimicrobial or Antifouling Agents

2019 ◽  
Vol 20 (19) ◽  
pp. 4866 ◽  
Author(s):  
Iolanda Francolini ◽  
Antonella Piozzi
Keyword(s):  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Polymeric Systems

The rapid increase in the emergence of antibiotic-resistant bacterial strains combined with a dwindling rate of discovery of novel antibiotic molecules has lately created an alarming issue worldwide [...]

scholarly journals Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system

2016 ◽  
Vol 52 (69) ◽  
pp. 10525-10528 ◽  
Author(s):  
Saemi O. Poelma ◽  
Seung Soo Oh ◽  
Sameh Helmy ◽  
Abigail S. Knight ◽  
G. Leslie Burnett ◽  
...  
Keyword(s):  
Drug Release ◽  
Visible Light ◽  
Small Molecules ◽  
Cancer Cells ◽  
Controlled Drug Release ◽  
Micellar System ◽  
On Demand ◽  
System P

We present a one-photon visible light-responsive micellar system for efficient, on-demand delivery of small molecules.

scholarly journals Ru(II)-Dppz Derivatives and Their Interactions with DNA: Thirty Years and Counting

2021 ◽  
Vol 11 (7) ◽  
pp. 3038
Author(s):  
Maria Letizia Di Pietro ◽  
Giuseppina La Ganga ◽  
Francesco Nastasi ◽  
Fausto Puntoriero
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Small Molecules ◽  
Transition Metal Complexes ◽  
Mechanism Of Action ◽  
Spectroscopic Techniques ◽  
Biological Applications ◽  
Ancillary Ligands ◽  
Structural Modifications ◽  
Over Time

Transition metal complexes with dppz-type ligands (dppz = dipyrido[3,2-a:2′,3′-c]phenazine) are extensively studied and attract a considerable amount of attention, becoming, from the very beginning and increasingly over time, a powerful tool for investigating the structure of the DNA helix. In particular, [Ru(bpy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ and their derivatives were extensively investigated as DNA light-switches. The purpose of this mini-review, which is not and could not be exhaustive, was to first introduce DNA and its importance at a biological level and research in the field of small molecules that are capable of interacting with it, in all its forms. A brief overview is given of the results obtained on the Ru-dppz complexes that bind to DNA. The mechanism of the light-switch active in this type of species is also briefly introduced along with its effects on structural modifications on both the dppz ligand and the ancillary ligands. Finally, a brief mention is made of biological applications and the developments obtained due to new spectroscopic techniques, both for understanding the mechanism of action and for cellular imaging applications.

Targeting the phosphoinositide 3-kinase/AKT pathways by small molecules and natural compounds as a therapeutic approach for breast cancer cells

2019 ◽  
Vol 46 (5) ◽  
pp. 4809-4816 ◽  
Author(s):  
Amin Soltani ◽  
Samira Torki ◽  
Milad Sabzevary Ghahfarokhi ◽  
Mohammad Saied Jami ◽  
Mahdi Ghatrehsamani
Keyword(s):  
Breast Cancer ◽  
Small Molecules ◽  
Cancer Cells ◽  
Therapeutic Approach ◽  
Breast Cancer Cells ◽  
Natural Compounds ◽  
Phosphoinositide 3 Kinase
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