Efficient construction of diverse 3-cyanoindoles under novel tandem catalysis

2020 ◽  
Vol 56 (83) ◽  
pp. 12660-12663
Author(s):  
Jun Wu ◽  
Jiabin Liu ◽  
Kerui Zhou ◽  
Zhenni He ◽  
Qian Wang ◽  
...  
Keyword(s):  
Tandem Reactions ◽  
Tandem Catalysis ◽  
Rapid Construction ◽  
Palladium Catalyzed ◽  
Efficient Construction

A novel and rapid construction of 3-cyanoindoles by palladium-catalyzed tandem reactions has been developed.

Stereoselective synthesis of 2,5-disubstituted pyrrolidines via gold-catalysed anti-Markovnikov hydroamination-initiated tandem reactions

2019 ◽  
Vol 55 (67) ◽  
pp. 9923-9926 ◽  
Author(s):  
Tong-De Tan ◽  
Yang-Bo Chen ◽  
Ming-Yang Yang ◽  
Jia-Le Wang ◽  
Hao-Ze Su ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Tandem Reactions ◽  
Rapid Construction

A series of gold-catalyzed intramolecular hydroamination-initiated azidation, allylation and heteroarylation reactions enable the rapid construction of enantioenriched 2,5-disubstituted pyrrolidines.

scholarly journals Tandem Catalysis: Synthesis of Nitrogen-Containing Heterocycles

Catalysts ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 631 ◽  
Author(s):  
Joana F. Campos ◽  
Sabine Berteina-Raboin
Keyword(s):  
Medicinal Chemistry ◽  
Nitrogen Heterocycles ◽  
Tandem Reactions ◽  
Tandem Catalysis

In this Review, we consider all the publications since the beginning of the century that describe tandem reactions resulting in the formation of five-membered aromatic nitrogen heterocycles (thiazole, imidazole, indole, tetrazole, triazole, and isoxazole). The contents of this review are organized by taxonomy and type of tandem catalysis. It covers orthogonal, auto-, and assisted tandem catalysis, providing an overview of tandem reactions applied tonitrogen heterocycles reported in the literature up to March 2020. We believe that this compilation of data will provide a necessary starting reference to developthe applications of tandem catalysis in medicinal chemistry.

Synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids

2017 ◽  
Vol 15 (29) ◽  
pp. 6080-6083 ◽  
Author(s):  
Xiaoxiang Zhang ◽  
Ping Li ◽  
Chang Lyu ◽  
Wanxiong Yong ◽  
Jing Li ◽  
...  
Keyword(s):  
Efficient Method ◽  
Tandem Reactions ◽  
Sulfonic Acids ◽  
Palladium Catalyzed

An efficient method for the synthesis of 1H-indole-3-sulfonates via palladium-catalyzed tandem reactions of 2-alkynyl arylazides with sulfonic acids has been developed.

ChemInform Abstract: Auto-Tandem Catalysis: Synthesis of Substituted 11H-Indolo[3,2-c]quinolines via Palladium-Catalyzed Intermolecular C-N and Intramolecular C-C Bond Formation.

ChemInform ◽  
2008 ◽  
Vol 39 (27) ◽  
Author(s):  
Caroline Meyers ◽  
Geert Rombouts ◽  
Kristof T. J. Loones ◽  
Alberto Coelho ◽  
Bert U. W. Maes
Keyword(s):  
Bond Formation ◽  
Tandem Catalysis ◽  
Palladium Catalyzed

scholarly journals Palladium-Catalyzed Carbocyclizations of Unactivated Alkyl Bromides with Alkenes Involving Auto-tandem Catalysis

2017 ◽  
Vol 139 (33) ◽  
pp. 11595-11600 ◽  
Author(s):  
Alexander R. O. Venning ◽  
Megan R. Kwiatkowski ◽  
Joan E. Roque Peña ◽  
Brendan C. Lainhart ◽  
Akil A. Guruparan ◽  
...  
Keyword(s):  
Tandem Catalysis ◽  
Alkyl Bromides ◽  
Palladium Catalyzed

scholarly journals Pd-catalyzed Auto-Tandem Cascades Based on N-Sulfonylhydrazones: Hetero- and Carbocyclization Processes

Synthesis ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 4434-4447 ◽  
Author(s):  
Carlos Valdés ◽  
Raquel Barroso ◽  
María Cabal
Keyword(s):  
Molecular Diversity ◽  
Short Review ◽  
Tandem Reactions ◽  
Tandem Catalysis ◽  
Bond Forming ◽  
Organic Halides ◽  
Bond Forming Reactions ◽  
Cascade Processes ◽  
Linear Molecules ◽  
Tandem Cascades

The Pd-catalyzed cross-coupling between N-tosylhydrazones and organic halides is a powerful method for the creation of C–C bonds. This transformation has been included recently in cascade processes in which the same catalyst promotes various independent catalytic steps, a process known as auto-tandem catalysis. This strategy proves to be very useful for the construction of relatively complex carbo- and heterocyclic structures, as well as for the generation of molecular diversity. This short review will cover the different Pd-catalyzed auto-tandem reactions­ involving N-tosylhydrazones organized by the bond-forming sequence: C–C/C–N and C–C/C–C. Some examples of related tandem reactions leading to acyclic compounds are also highlighted.1 Introduction2 Auto-Tandem C–C/C–N Bond-Forming Reactions3 Auto-Tandem C–C/C–C Bond-Forming Reactions4 Tandem Reactions for the Synthesis of Linear Molecules5 Summary and Outlook

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