scholarly journals Bioorthogonal chemistry-based RNA labeling technologies: evolution and current state

2020 ◽  
Vol 56 (82) ◽  
pp. 12307-12318
Author(s):  
Jerrin Thomas George ◽  
Seergazhi G. Srivatsan
Keyword(s):  
Bioorthogonal Chemistry ◽  
Feature Article ◽  
Current State ◽  
Rna Labeling ◽  
Recent Developments

Recent developments and applications of bioorthogonal chemistry to label RNA by transcription and posttranscription chemo-enzymatic approaches are described in this feature article.

N-Heterocyclic silylene in coinage metal chemistry: an account of recent advances

2021 ◽  
Author(s):  
Moushakhi Ghosh ◽  
Shabana Khan
Keyword(s):  
Exponential Growth ◽  
Coinage Metal ◽  
Feature Article ◽  
Metal Chemistry ◽  
Recent Advances ◽  
Recent Developments

This feature article intends to highlight and comprehensively summarize the recent developments in the field of silylene-coinage metal chemistry. Recent years have witnessed exponential growth in the utilization of N-heterocyclic...

scholarly journals Sensory Attenuation in the Auditory Modality as a Window Into Predictive Processing

2021 ◽  
Vol 15 ◽  
Author(s):  
Fabian Kiepe ◽  
Nils Kraus ◽  
Guido Hesselmann
Keyword(s):  
Predictive Coding ◽  
Research Area ◽  
Predictive Processing ◽  
Auditory Modality ◽  
Auditory Input ◽  
Current State ◽  
Recent Developments ◽  
Sensory Attenuation ◽  
The Impact ◽  
Predictive Mechanisms

Self-generated auditory input is perceived less loudly than the same sounds generated externally. The existence of this phenomenon, called Sensory Attenuation (SA), has been studied for decades and is often explained by motor-based forward models. Recent developments in the research of SA, however, challenge these models. We review the current state of knowledge regarding theoretical implications about the significance of Sensory Attenuation and its role in human behavior and functioning. Focusing on behavioral and electrophysiological results in the auditory domain, we provide an overview of the characteristics and limitations of existing SA paradigms and highlight the problem of isolating SA from other predictive mechanisms. Finally, we explore different hypotheses attempting to explain heterogeneous empirical findings, and the impact of the Predictive Coding Framework in this research area.

Nano-Sized and Nanocrystalline Calcium Orhophosphates in Biomedical Engineering

2009 ◽  
Vol 3 ◽  
pp. 59-92 ◽  
Author(s):  
Sergey V. Dorozhkin
Keyword(s):  
Bone Repair ◽  
Dental Enamel ◽  
Building Blocks ◽  
Research Area ◽  
Future Research ◽  
Biological Origin ◽  
Current State ◽  
Calcium Orthophosphates ◽  
Recent Developments ◽  
Hard Tissue Engineering

There has been much recent activity in the research area of nanoparticles and nanocrystalline materials, in many fields of science and technology. This is due to their outstanding and unique physical, mechanical, chemical and biological characteristics. Recent developments in biomineralization have demonstrated that nano-sized particles play an important role in the formation of the hard tissues of animals. It is well established that the basic inorganic building blocks of bones and teeth of mammals are nano-sized and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds of nanocrystals of biological apatite are found to combine into self-assembled structures under the control of bio-organic matrixes. It was also confirmed experimentally that the structure of both dental enamel and bones could be mimicked by an oriented aggregation of nano-sized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nano-sized and nanocrystalline calcium orthophosphates for clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various cells were detected on smaller crystals of calcium orthophosphates. Furthermore, studies revealed that the differentiation of various cells was promoted by nano-sized calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have the potential to revolutionize the field of hard tissue engineering, in areas ranging from bone repair and augmentation to controlled drug delivery devices. This paper reviews the current state of knowledge and recent developments of various nano-sized and nanocrystalline calcium orthophosphates, covering topics from the synthesis and characterization to biomedical and clinical applications. This review also provides possible directions of future research and development.

Institutional Theory and E-Government Research

2008 ◽  
pp. 349-360 ◽  
Author(s):  
Shahidul Hassan ◽  
J. Ramon Gil-Garcia
Keyword(s):  
Information Systems ◽  
Institutional Theory ◽  
Information Technologies ◽  
Future Research ◽  
Fourth Section ◽  
Current State ◽  
Starting Point ◽  
Recent Developments ◽  
Good Starting Point ◽  
Government Research

Recent developments in institutional theory are highly promising for the study of e-government. Scholars in various disciplines, such as economics (North, 1999; Rutherford, 1999), sociology (Brinton & Nee, 1998), and political science (March & Olsen, 1989; Peters, 2001), have used institutional approaches to understand diverse social and organizational phenomena. Insights gained from these studies can be valuable for guiding research in e-government. In fact, there are some initial efforts in information systems and e-government research that have applied institutional theory and proved useful in generating new insights about how information technologies are adopted (Teo, Wei, & Benbasat, 2003; Tingling & Parent, 2002), designed and developed (Butler, 2003; Klein, 2000; Laudon, 1985), implemented (Robey & Holmstrom, 2001), and used (Fountain, 2001) in organizations. In this chapter, we provide a brief overview of some of these initial studies to highlight the usefulness of institutional theory in e-government research. We also suggest some opportunities for future research in e-government using institutional theory. This chapter does not capture all the essential theoretical and empirical issues related to using institutional theory in information systems and e-government research. Instead, it is a brief review and a good starting point to explore the potential of institutional theory. We hope that e-government scholars find it interesting and useful. The chapter is organized in five sections, including this introduction. The second section provides a brief overview of institutional theory in various disciplinary traditions, with an emphasis on institutional theory in sociology. Then the chapter identifies various patterns of the use of institutional theory in information systems and e-government research. Based on our analysis of the current state of the art, the fourth section suggests some opportunities for future research. Finally, the fifth section provides some final comments.

Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs

2019 ◽  
Vol 48 (4) ◽  
pp. 1077-1094 ◽  
Author(s):  
Xingyue Ji ◽  
Zhixiang Pan ◽  
Bingchen Yu ◽  
Ladie Kimberly De La Cruz ◽  
Yueqin Zheng ◽  
...  
Keyword(s):  
Small Molecule ◽  
Bioorthogonal Chemistry ◽  
On Demand ◽  
Recent Developments

This review summarizes recent developments in using bioorthogonal chemistry in prodrug design for the delivery of traditional small molecule- and gasotransmitter-based therapeutics.

Recent developments in pharmacotherapy for hypertriglyceridemia: what’s the current state of the art?

2019 ◽  
Vol 21 (1) ◽  
pp. 107-120 ◽  
Author(s):  
Matilda Florentin ◽  
Michael S Kostapanos ◽  
Panagiotis Anagnostis ◽  
George Liamis
Keyword(s):  
State Of The Art ◽  
Current State ◽  
Recent Developments

Sydnone–alkyne cycloaddition: applications in synthesis and bioconjugation

2017 ◽  
Vol 53 (84) ◽  
pp. 11515-11527 ◽  
Author(s):  
Elodie Decuypère ◽  
Lucie Plougastel ◽  
Davide Audisio ◽  
Frédéric Taran
Keyword(s):  
Reaction Conditions ◽  
Feature Article ◽  
Recent Developments

This feature article aims at providing an overview of the recent developments in sydnone–alkyne cycloadditions. Particular attention has been focused on the strategies for achieving high regiocontrol, milder reaction conditions and applications in the field of click and biorthogonal chemistry.

scholarly journals The Pope’s Jesus book and the Christologies of the gospels

2011 ◽  
Vol 67 (1) ◽  
Author(s):  
Wim J.C. Weren
Keyword(s):  
Final Section ◽  
Semantic Analysis ◽  
Historical Jesus ◽  
Redaction Criticism ◽  
Benedict Xvi ◽  
Current State ◽  
Recent Developments ◽  
Literary Figure ◽  
State Of Research ◽  
Further Development

This article maps out recent developments in the exegetical investigation of Jesus. It starts with a discussion of the Jesus book by Joseph Ratzinger/Benedict XVI, in which ‘canonical exegesis’ is used to argue that Johannine Christology is also present in the other gospels and that this Christology actually goes back to Jesus. In this way, the book narrows the gap between the historical Jesus and the Christ of faith. The next section argues for maintaining the multiplicity of images of Jesus as a literary figure that is the fruit of relatively recent approaches: redaction criticism, narrative-semantic analysis and intertextuality. The final section contains a sketch of the current state of research on the historical Jesus and its relevance for Christology. The multiplicity in the literary and historical approaches poses challenges to the further development of Christology.

scholarly journals Superhydrophobic surfaces

2012 ◽  
Vol 21 (1-2) ◽  
pp. 21-32 ◽  
Author(s):  
Ioannis Karapanagiotis ◽  
Panagiotis Manoudis
Keyword(s):  
Water Repellency ◽  
Superhydrophobic Surfaces ◽  
Water Repellent ◽  
Baxter Equation ◽  
Feature Article ◽  
Surface Protection ◽  
Recent Developments ◽  
Potential Applications ◽  
Nanoparticle Composites ◽  
Potential Use

AbstractSuperhydrophobicity – also known as water repellency – has recently attracted considerable attention because of its numerous potential applications. However, the fundamental concepts and equations describing the wettability of superhydrophobic surfaces have been known since the 1940s. These concepts are reviewed and discussed in the present feature article in light of the recent developments. Furthermore, the potential use of water-repellent siloxane-nanoparticle composites for surface protection and consolidation of stones and mortars used in outdoor objects of cultural heritage is investigated. Finally, it is shown that the wettability of the composite surfaces can be predicted by the Cassie-Baxter equation.

Functional Neuroimaging of PTSD

2016 ◽  
Author(s):  
Marie-France Marin ◽  
Mohammed R. Milad
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Functional Neuroimaging ◽  
Post Traumatic Stress ◽  
Key Factors ◽  
Current State ◽  
Recent Developments ◽  
Post Traumatic ◽  
Novel Approaches

The merger of neuroscience and psychiatry during the last two decades has enabled psychiatric neuroscience, as a newly refined discipline, to make great advances in understanding pathophysiology of psychiatric disorders, including post-traumatic stress disorder (PTSD). The advent of neuroimaging tools and the continued exponential growth and sophistication of the methods are key factors underlying advances in the field. In this chapter, informed by neuroimaging tools and basic neuroscience, the authors paint an optimistic canvas to illustrate the current state of knowledge pertaining to the etiology and pathophysiology of PTSD. The chapter describes the state of some recent developments and what is coming on the horizon in terms of novel approaches that may be applied toward the diagnosis and treatment of PTSD.

Sign in / Sign up

Export Citation Format

Share Document