Sydnone–alkyne cycloaddition: applications in synthesis and bioconjugation

2017 ◽  
Vol 53 (84) ◽  
pp. 11515-11527 ◽  
Author(s):  
Elodie Decuypère ◽  
Lucie Plougastel ◽  
Davide Audisio ◽  
Frédéric Taran
Keyword(s):  
Reaction Conditions ◽  
Feature Article ◽  
Recent Developments

This feature article aims at providing an overview of the recent developments in sydnone–alkyne cycloadditions. Particular attention has been focused on the strategies for achieving high regiocontrol, milder reaction conditions and applications in the field of click and biorthogonal chemistry.

scholarly journals Visible Light Photochemical Reactions for Nucleic Acid-Based Technologies

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 556
Author(s):  
Bonwoo Koo ◽  
Haneul Yoo ◽  
Ho Jeong Choi ◽  
Min Kim ◽  
Cheoljae Kim ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Visible Light ◽  
Chemical Reactions ◽  
Chemical Biology ◽  
Photochemical Reactions ◽  
Reaction Conditions ◽  
Promising Tool ◽  
Recent Developments ◽  
Visible Light Driven

The expanding scope of chemical reactions applied to nucleic acids has diversified the design of nucleic acid-based technologies that are essential to medicinal chemistry and chemical biology. Among chemical reactions, visible light photochemical reaction is considered a promising tool that can be used for the manipulations of nucleic acids owing to its advantages, such as mild reaction conditions and ease of the reaction process. Of late, inspired by the development of visible light-absorbing molecules and photocatalysts, visible light-driven photochemical reactions have been used to conduct various molecular manipulations, such as the cleavage or ligation of nucleic acids and other molecules as well as the synthesis of functional molecules. In this review, we describe the recent developments (from 2010) in visible light photochemical reactions involving nucleic acids and their applications in the design of nucleic acid-based technologies including DNA photocleaving, DNA photoligation, nucleic acid sensors, the release of functional molecules, and DNA-encoded libraries.

N-Heterocyclic silylene in coinage metal chemistry: an account of recent advances

2021 ◽  
Author(s):  
Moushakhi Ghosh ◽  
Shabana Khan
Keyword(s):  
Exponential Growth ◽  
Coinage Metal ◽  
Feature Article ◽  
Metal Chemistry ◽  
Recent Advances ◽  
Recent Developments

This feature article intends to highlight and comprehensively summarize the recent developments in the field of silylene-coinage metal chemistry. Recent years have witnessed exponential growth in the utilization of N-heterocyclic...

scholarly journals Enzymatic Bioreactors: An Electrochemical Perspective

Catalysts ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1232
Author(s):  
Simin Arshi ◽  
Mehran Nozari-Asbemarz ◽  
Edmond Magner
Keyword(s):  
Direct Electron Transfer ◽  
High Surface ◽  
High Surface Area ◽  
Enzyme Engineering ◽  
Future Perspective ◽  
Enzymatic System ◽  
Reaction Conditions ◽  
Flow Reactors ◽  
Recent Developments ◽  
Enzyme Cascades

Biocatalysts provide a number of advantages such as high selectivity, the ability to operate under mild reaction conditions and availability from renewable resources that are of interest in the development of bioreactors for applications in the pharmaceutical and other sectors. The use of oxidoreductases in biocatalytic reactors is primarily focused on the use of NAD(P)-dependent enzymes, with the recycling of the cofactor occurring via an additional enzymatic system. The use of electrochemically based systems has been limited. This review focuses on the development of electrochemically based biocatalytic reactors. The mechanisms of mediated and direct electron transfer together with methods of immobilising enzymes are briefly reviewed. The use of electrochemically based batch and flow reactors is reviewed in detail with a focus on recent developments in the use of high surface area electrodes, enzyme engineering and enzyme cascades. A future perspective on electrochemically based bioreactors is presented.

scholarly journals Superhydrophobic surfaces

2012 ◽  
Vol 21 (1-2) ◽  
pp. 21-32 ◽  
Author(s):  
Ioannis Karapanagiotis ◽  
Panagiotis Manoudis
Keyword(s):  
Water Repellency ◽  
Superhydrophobic Surfaces ◽  
Water Repellent ◽  
Baxter Equation ◽  
Feature Article ◽  
Surface Protection ◽  
Recent Developments ◽  
Potential Applications ◽  
Nanoparticle Composites ◽  
Potential Use

AbstractSuperhydrophobicity – also known as water repellency – has recently attracted considerable attention because of its numerous potential applications. However, the fundamental concepts and equations describing the wettability of superhydrophobic surfaces have been known since the 1940s. These concepts are reviewed and discussed in the present feature article in light of the recent developments. Furthermore, the potential use of water-repellent siloxane-nanoparticle composites for surface protection and consolidation of stones and mortars used in outdoor objects of cultural heritage is investigated. Finally, it is shown that the wettability of the composite surfaces can be predicted by the Cassie-Baxter equation.

scholarly journals Iodonium-Catalyzed Carbonyl–Olefin Metathesis Reactions

Synlett ◽  
2019 ◽  
Vol 30 (17) ◽  
pp. 1966-1970 ◽  
Author(s):  
Giulia Oss ◽  
Thanh Vinh Nguyen
Keyword(s):  
Transition Metal ◽  
Organic Compounds ◽  
Organic Synthesis ◽  
Olefin Metathesis ◽  
Lewis Acids ◽  
Functional Group ◽  
Iodine Monochloride ◽  
Metathesis Reaction ◽  
Reaction Conditions ◽  
Recent Developments

The carbonyl–olefin metathesis reaction has become increasingly important in organic synthesis due to its versatility in functional group interconversion chemistry. Recent developments in the field have identified a number of transition-metal and organic Lewis acids as effective catalysts for this reaction. Herein, we report the use of simple organic compounds such as N-iodosuccinimide or iodine monochloride to catalyze the carbonyl–olefin metathesis process under mild reaction conditions. This work broadens the scope of this chemical transformation to include iodonium sources as simple and practical catalysts.

scholarly journals Recent Advances in Flavin-Dependent Halogenase Biocatalysis: Sourcing, Engineering, and Application

Catalysts ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1030 ◽  
Author(s):  
Johannes Büchler ◽  
Athena Papadopoulou ◽  
Rebecca Buller
Keyword(s):  
Small Molecule ◽  
Halogen Atom ◽  
Reaction Engineering ◽  
Special Focus ◽  
Molecular Scaffolds ◽  
Reaction Conditions ◽  
Bioactive Substances ◽  
Application Range ◽  
Technological Value ◽  
Recent Developments

The introduction of a halogen atom into a small molecule can effectively modulate its properties, yielding bioactive substances of agrochemical and pharmaceutical interest. Consequently, the development of selective halogenation strategies is of high technological value. Besides chemical methodologies, enzymatic halogenations have received increased interest as they allow the selective installation of halogen atoms in molecular scaffolds of varying complexity under mild reaction conditions. Today, a comprehensive library of aromatic halogenases exists, and enzyme as well as reaction engineering approaches are being explored to broaden this enzyme family’s biocatalytic application range. In this review, we highlight recent developments in the sourcing, engineering, and application of flavin-dependent halogenases with a special focus on chemoenzymatic and coupled biosynthetic approaches.

scholarly journals Host–guest chemistry in two-dimensional supramolecular networks

2016 ◽  
Vol 52 (77) ◽  
pp. 11465-11487 ◽  
Author(s):  
Joan Teyssandier ◽  
Steven De Feyter ◽  
Kunal S. Mali
Keyword(s):  
Two Dimensional ◽  
Feature Article ◽  
Recent Developments ◽  
Supramolecular Networks ◽  
Guest Chemistry

In this feature article, we survey recent developments in host–guest chemistry studied in surface-adsorbed physisorbed supramolecular networks.

scholarly journals Straightforward Strategies for the Preparation of NH-Sulfox­imines: A Serendipitous Story

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2525-2538 ◽  
Author(s):  
James Bull ◽  
Renzo Luisi ◽  
Leonardo Degennaro
Keyword(s):  
Transition Metal ◽  
Physicochemical Properties ◽  
Direct Synthesis ◽  
Transition Metal Catalysts ◽  
Hypervalent Iodine ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Recent Developments ◽  
New Procedures

Sulfoximines are emerging as valuable new isosteres for use in medicinal chemistry, with the potential to modulate physicochemical properties. Recent developments in synthetic strategies have made the unprotected ‘free’ NH-sulfoximine group more readily available, facilitating further study. This account reviews approaches to NH-sulfoximines, with a focus on our contribution to the field. Starting from the development of catalytic strategies involving transition metals, more sustainable metal-free processes have been discovered. In particular, the use of hypervalent iodine reagents to mediate NH-transfer to sulfoxides is described, along with an assessment of the substrate scope. Furthermore, a one-pot strategy to convert sulfides directly into NH-sulfoximines is discussed, with N- and O-transfer occurring under the reaction conditions. Mechanistic evidence for the new procedures is included as well as relevant synthetic applications that further exemplify the potential of these approaches.1 Introduction2 Strategies to Form NH-Sulfoximines Involving Transition-Metal Catalysts3 Metal-Free Strategies to Prepare NH-Sulfoximines4 Mechanistic Evidence for the Direct Synthesis of NH-Sulfoximines from Sulfoxides and Sulfides5 Further Applications6 Conclusion

scholarly journals Bioorthogonal chemistry-based RNA labeling technologies: evolution and current state

2020 ◽  
Vol 56 (82) ◽  
pp. 12307-12318
Author(s):  
Jerrin Thomas George ◽  
Seergazhi G. Srivatsan
Keyword(s):  
Bioorthogonal Chemistry ◽  
Feature Article ◽  
Current State ◽  
Rna Labeling ◽  
Recent Developments

Recent developments and applications of bioorthogonal chemistry to label RNA by transcription and posttranscription chemo-enzymatic approaches are described in this feature article.

Recent Developments on the Synthesis of Biologically Significant bis/tris(indolyl)methanes under Various Reaction Conditions: A Review

2020 ◽  
Vol 24 (6) ◽  
pp. 583-621
Author(s):  
Arvind Singh ◽  
Gurpreet Kaur ◽  
Bubun Banerjee
Keyword(s):  
Ionic Liquids ◽  
Bioactive Compounds ◽  
Building Block ◽  
Heterogeneous Catalysts ◽  
Metal Catalysts ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Wide Range ◽  
Anti Cancer ◽  
Recent Developments

Bis(indolyl)methane skeleton is the main building block of many naturally occurring bioactive compounds. Bis(indolyl)methanes are found to possess a wide range of pharmaceuitical efficacies. These important scaffolds are being used as anti-cancer, antioxidant, anti-bacterial, anti-inflammatory, and anti-proliferative agents. In this review, we summarized the latest developments on the synthesis of various bis/tris(indolyl)methane derivatives from the reactions of two equivalents of indoles and one equivalent of aldehydes or indole-3-carbaldehydes under various reaction conditions. More than hundred different catalysts were employed for these transformations which include various metal catalysts, ionic liquids, organocatalysts, surfactants, homogeneous, heterogeneous catalysts etc.

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