High peroxidase-mimicking activity of gold@platinum bimetallic nanoparticle-supported molybdenum disulfide nanohybrids for the selective colorimetric analysis of cysteine

2020 ◽  
Vol 56 (82) ◽  
pp. 12351-12354
Author(s):  
Ling Wan ◽  
Liquan Wu ◽  
Shao Su ◽  
Dan Zhu ◽  
Jie Chao ◽  
...  
Keyword(s):  
High Activity ◽  
Molybdenum Disulfide ◽  
Colorimetric Sensor ◽  
Colorimetric Analysis ◽  
Bimetallic Nanoparticle ◽  
Gold Platinum

A sensitive and selective colorimetric sensor was designed for cysteine detection based on a high activity peroxidase-mimicking gold@platinum bimetallic nanoparticle-supported molybdenum disulfide nanohybrid.

A colorimetric sensor for detecting thiourea based on inhibiting peroxidase-like activity of gold–platinum nanoparticles

2021 ◽  
Author(s):  
Yuqi Zhao ◽  
Qingjie Fu ◽  
Xiaoqian Cui ◽  
Hui Chi ◽  
Yongzhuang Lu ◽  
...  
Keyword(s):  
Platinum Nanoparticles ◽  
Color Change ◽  
Colorimetric Sensor ◽  
Gold Platinum

The sensor is based on the peroxidase-like activity of Au@PtNPs. Thiourea can quickly be detected by the color change of the solution. The method was applied to the determination of thiourea in practical samples.

Gold–platinum bimetallic nanoclusters with enhanced peroxidase-like activity and their integrated agarose hydrogel-based sensing platform for the colorimetric analysis of glucose levels in serum

The Analyst ◽  
2017 ◽  
Vol 142 (21) ◽  
pp. 4106-4115 ◽  
Author(s):  
Jiayu Feng ◽  
Pengcheng Huang ◽  
Fang-Ying Wu
Keyword(s):  
Human Serum ◽  
Direct Visualization ◽  
Colorimetric Analysis ◽  
Glucose Levels ◽  
Bimetallic Nanoclusters ◽  
Sensing Platform ◽  
Agarose Hydrogel ◽  
Gold Platinum

Bimetallic Au–PtNCs with enhanced peroxidase-like activity were integrated into agarose hydrogels for direct visualization of glucose in human serum.

Molybdenum disulfide synthesized by molybdenum-based metal organic framework with high activity for sodium ion battery

2021 ◽  
Vol 365 ◽  
pp. 137353
Author(s):  
Changjian He ◽  
Weihao Yin ◽  
Xiaochun Li ◽  
Jie Zheng ◽  
Bohejin Tang ◽  
...  
Keyword(s):  
High Activity ◽  
Molybdenum Disulfide ◽  
Metal Organic Framework ◽  
Sodium Ion ◽  
Sodium Ion Battery ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Heterogeneous Rh and Rh/Ag bimetallic nanoparticle catalysts immobilized on chiral polymers

2019 ◽  
Vol 10 (32) ◽  
pp. 7619-7626 ◽  
Author(s):  
Hyemin Min ◽  
Hiroyuki Miyamura ◽  
Tomohiro Yasukawa ◽  
Shū Kobayashi
Keyword(s):  
High Activity ◽  
Asymmetric Reactions ◽  
Chiral Polymers ◽  
Nanoparticle Catalysts ◽  
Bimetallic Nanoparticle ◽  
Flow Systems

We have developed novel heterogeneous chiral Rh and Rh/Ag NP catalysts immobilized on a chiral diene-containing polymer. The catalysts showed high activity in asymmetric reactions in both batch and flow systems.

High-activity samarium-153-EDTMP therapy followed by autologous peripheral blood stem cell support in unresectable osteosarcoma

2001 ◽  
Vol 40 (06) ◽  
pp. 215-220 ◽  
Author(s):  
S. Bielack ◽  
S. Flege ◽  
J. Eckardt ◽  
J. Sciuk ◽  
H. Jürgens ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
High Activity ◽  
Peripheral Blood ◽  
Peripheral Blood Stem Cell ◽  
Blood Stem Cell ◽  
High Dose ◽  
External Radiotherapy ◽  
Primary Tumor Site ◽  
Hematopoietic Stem

Summary Purpose: Despite highly efficacious chemotherapy, patients with osteosarcomas still have a poor prognosis if adequate surgical control cannot be obtained. These patients may benefit from therapy with radiolabeled phosphonates. Patients and Methods: Six patients (three male, three female; seven to 41 years) with unresectable primary osteosarcoma (n = 3) or unresectable recurrent sites of osteosarcomas (n = 3) were treated with high-activity of Sm-153-EDTMP (150 MBq/kg BW). In all patients autologous peripheral blood stem cells had been collected before Sm-153-EDTMP therapy. Results: No immediate adverse reactions were observed in the patients. In one patient bone pain increased during the first 48 hrs after therapy. Three patients received pain relief. Autologous peripheral blood stem cell reinfusion was performed on day +12 to +27 in all patients to overcome potentially irreversible damage to the hematopoietic stem cells. In three patient external radiotherapy of the primary tumor site was performed after Sm-153-EDTMP therapy and in two of them polychemotherapy was continued. Thirty-six months later one of these patients is still free of progression. Two further patients are still alive. However, they have developed new metastases. The three patients who had no accompanying external radiotherapy, all died of disease progression five to 20 months after therapy. Conclusion: These preliminary results show that high-dose Sm-153-EDTMP therapy is feasible and warrants further evaluation of efficacy. The combination with external radiation and polychemotherapy seems to be most promising. Although osteosarcoma is believed to be relatively radioresistant, the total focal dose achieved may delay local progression or even achieve permanent local tumor control in patients with surgically inaccessible primary or relapsing tumors.

Gastric Fibrinolysis

1975 ◽  
Vol 34 (02) ◽  
pp. 409-418 ◽  
Author(s):  
I. M Nilsson ◽  
S.-E Bergentz ◽  
U Hedner ◽  
K Kullenberg
Keyword(s):  
Gastric Ulcer ◽  
Gastric Juice ◽  
High Activity ◽  
Fibrinolytic Activity ◽  
Duodenal Juice ◽  
Bleeding Tendency ◽  
Local Fibrinolysis ◽  
Heated Plates

SummaryGastric juice from 15 normals, 20 patients with gastric ulcer and 4 patients with erosive haemorrhagic gastroduodenitis was investigated in respect of its activity on unheated and heated fibrin plates and its content of FDP and plasminogen or plasmin with immunochemical methods. Gastric juice from normals showed no activity on unheated and heated fibrin plates, and no FDP or plasminogen could be demonstrated. In the patients with gastric ulcer the gastric juice showed little or no fibrinolytic activity on fibrin plates except in 2, who had regurgitation of duodenal juice and neutral pH of the juice. These patients had equally high activity on heated as on unheated plates and no plasmin could be demonstrated. It was shown that this activity was not due to fibrinolysis, but to non-specific proteolytic activity (probably trypsin). The patients with erosive haemorrhagic gastroduodenitis exhibited quite a different picture. The gastric juice from these patients showed extremely high activity on fibrin plates, the activity was higher on unheated than on heated plates. The activity was inhibited in vitro by addition of EACA and in vivo after administration of AMCA. The occurrence of plasmin could be demonstrated directly immunologically in the gastric juice. By comparison of plasmin and trypsin in various assays it could further be proved that the gastric juice in these cases contained plasminogen activator and plasmin. The patients with erosive haemorrhagic gastroduodenitis showed no increase in fibrinolysis in the blood, but low values for plasminogen and α2M, and the serum contained FDP. These findings in the blood and gastric juice were interpreted as signs of local fibrinolysis in the stomach and duodenum. There is reason to assume that this gastric fibrinolysis contributes substantially to the bleeding tendency. The effect of administration of AMCA on fibrinolytic activity and the haemorrhage lends support to the assumption of such a mechanism.

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