Addressing regio- and stereo-specificity challenges in the synthesis of nucleoside 2′,3′-cyclic monophosphate analogs – a rapid and facile synthesis of nucleoside-2′,3′-O,O-phosphoro-thioate or -selenoate, and elucidation of the origin of the rare specificity
A new facile, rapid, stereo- and regio-selective one-pot synthesis of nucleoside-2′,3′-O,O-phosphorothioate and selenoate analogs has been developed.