Lighting up metallohelices: from DNA binders to chemotherapy and photodynamic therapy

2020 ◽  
Vol 56 (55) ◽  
pp. 7537-7548
Author(s):  
Xuezhao Li ◽  
Zhuolin Shi ◽  
Jinguo Wu ◽  
Jinlong Wu ◽  
Cheng He ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Design ◽  
Future Perspectives ◽  
Feature Article ◽  
Antitumor Chemotherapy ◽  
Dna Binders

DNA distortion induced by metallodrugs is one of the main subjects for drug design. In this Feature Article, the developments of DNA-targeted metallohelices for antitumor chemotherapy and photodynamic therapy are presented with future perspectives.

scholarly journals Nanomedicine-Based Strategies Assisting Photodynamic Therapy for Hypoxic Tumors: State-of-the-Art Approaches and Emerging Trends

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 137
Author(s):  
Chun-Yan Shih ◽  
Pei-Ting Wang ◽  
Wu-Chou Su ◽  
Hsisheng Teng ◽  
Wei-Lun Huang
Keyword(s):  
Photodynamic Therapy ◽  
State Of The Art ◽  
Metal Organic Framework ◽  
Basic Knowledge ◽  
Future Perspectives ◽  
Effective Strategies ◽  
Emerging Trends ◽  
Tumor Tissues ◽  
Metal Organic ◽  
Manipulating Hypoxia

Since the first clinical cancer treatment in 1978, photodynamic therapy (PDT) technologies have been largely improved and approved for clinical usage in various cancers. Due to the oxygen-dependent nature, the application of PDT is still limited by hypoxia in tumor tissues. Thus, the development of effective strategies for manipulating hypoxia and improving the effectiveness of PDT is one of the most important area in PDT field. Recently, emerging nanotechnology has benefitted progress in many areas, including PDT. In this review, after briefly introducing the mechanisms of PDT and hypoxia, as well as basic knowledge about nanomedicines, we will discuss the state of the art of nanomedicine-based approaches for assisting PDT for treating hypoxic tumors, mainly based on oxygen replenishing strategies and the oxygen dependency diminishing strategies. Among these strategies, we will emphasize emerging trends about the use of nanoscale metal–organic framework (nMOF) materials and the combination of PDT with immunotherapy. We further discuss future perspectives and challenges associated with these trends in both the aspects of mechanism and clinical translation.

Structures, physicochemical properties, and applications of T–HgII–T, C–AgI–C, and other metallo-base-pairs

2015 ◽  
Vol 51 (98) ◽  
pp. 17343-17360 ◽  
Author(s):  
Yoshiyuki Tanaka ◽  
Jiro Kondo ◽  
Vladimír Sychrovský ◽  
Jakub Šebera ◽  
Takenori Dairaku ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Recent Progress ◽  
Future Perspectives ◽  
Base Pairs ◽  
Feature Article

In this feature article, recent progress and future perspectives of metal-mediated base-pairs such as T–Hg(ii)–T and C–Ag(i)–C are presented.

Cucurbit[n]uril-based amphiphiles that self-assemble into functional nanomaterials for therapeutics

2019 ◽  
Vol 55 (72) ◽  
pp. 10654-10664 ◽  
Author(s):  
Kyeng Min Park ◽  
Moon Young Hur ◽  
Suman Kr Ghosh ◽  
Deepak Ramdas Boraste ◽  
Sungwan Kim ◽  
...  
Keyword(s):  
Future Perspectives ◽  
Functional Nanomaterials ◽  
Feature Article

In this feature article, the two types (molecular amphiphile and supramolecular amphiphile) of CB-based amphiphiles, their self-assemblies and their applications for useful nanotherapeutics and theranostics are presented with future perspectives.

scholarly journals Current Status and Future Perspectives of the Photodynamic Therapy for Early Stage Cancer and Dysplasia of the Uterine Cervix

2012 ◽  
Vol 33 (2) ◽  
pp. 117-121
Author(s):  
Masaru Sakamoto ◽  
Ryusuke Kaya ◽  
Kiyohiko Miyake ◽  
Yasuko Koyamatsu ◽  
Makoto Motegi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Uterine Cervix ◽  
Early Stage ◽  
Current Status ◽  
Future Perspectives ◽  
Early Stage Cancer

scholarly journals Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy

2021 ◽  
Vol 22 (4) ◽  
pp. 1728
Author(s):  
Shujin Lin ◽  
Chun Liu ◽  
Xiao Han ◽  
Haowei Zhong ◽  
Cui Cheng
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Viral Vectors ◽  
Target Lesion ◽  
Future Perspectives ◽  
Good Safety Profile ◽  
Nanoparticle System ◽  
Delivery Vehicles ◽  
Viral Nanoparticles ◽  
Viral Nanoparticle

Photodynamic therapy (PDT) is a promising therapy due to its efficiency and accuracy. The photosensitizer is delivered to the target lesion and locally activated. Viral nanoparticles (VNPs) have been explored as delivery vehicles for PDT in recent years because of their favorable properties, including simple manufacture and good safety profile. They have great potential as drug delivery carriers in medicine. Here, we review the development of PDT photosensitizers and discuss applications of VNP-mediated photodynamic therapies and the performance of VNPs in the treatment of tumor cells and antimicrobial therapy. Furthermore, future perspectives are discussed for further developing novel viral nanocarriers or improving existing viral vectors.

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