Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect

2021 ◽  
Author(s):  
Mengyu Yao ◽  
Qingxia Zou ◽  
Wenwu Zou ◽  
Zhenze Xie ◽  
Zhihao Li ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan

Bifunctional scaffolds prepared by hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with good osteogenesis and anti-osteosarcoma effect is promising for bone tumor therapy.

Carboxymethyl-hexanoyl Chitosan Nanodroplets for Ultrasonic Imaging and Drug Delivery to Tumor

2018 ◽  
Vol 24 (15) ◽  
pp. 1682-1688 ◽  
Author(s):  
Yu Jinsui ◽  
Situ Bing ◽  
Luo Muhua ◽  
Li Yue ◽  
Liao Jianyi ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan ◽  
Great Promise ◽  
Ovarian Cancer Cells ◽  
Mechanical Index ◽  
Surface Charges ◽  
Particle Structure ◽  
Drug Release Profile ◽  
Hexanoyl Chitosan

Introduction: Although a great many strategies have been proposed for tumor-targeted chemotherapy, current delivery methods of anticancer drugs present limited success with inevitable systemic toxicity. The aim of this study was to develop a new kind of theranostic carrier for targeted tumor therapy. Methods: Prior to prepare CHC-PFP-DOX, carboxymethyl-hexanoyl chitosan (CHC) was synthesized by acylation of carboxymethyl chitosan. To develop CHC-PFP, perfluoropentane (PFP), an ultrasound gas precursor, was simultaneously encapsulated into the hydrophobic inner cores of pre-formulated CHC micelle in aqueous phase via using the oil in water (O/W) emulsion method. The size distribution and surface charges of these nanodroplets were measured and the morphology was observed by transmission electron microscopy (TEM). For ultrasound imaging application, in vitro model was established to evaluate the imaging of CHC-PFP-DOX under different concentration and mechanical index. After that, the anti-tumor effect of ultrasound combined with CHC-PFPDOX on ovarian cancer cells was investigated. Results: The resulting CHC-PFP-DOX had a nano-sized particle structure, with hydrophobic anticancer DOX/PFP inner cores and a hydrophilic carboxymethyl chitosan polymer outer shell. The favorable nano-scaled size offers the potential to extravagate from veins and accumulate in tumor tissues via enhanced permeation and retention (EPR) effect. Additionally, CHC-PFP-DOX showed the ability to serve as ultrasound imaging agent at body temperature. Notably, it exhibited an ultrasound-triggered drug release profile through the external ultrasound irradiation. Further study demonstrated that ultrasound combined with CHC-PFP-DOX can improve the killing effect of chemotherapy for tumor. Conclusion: CHC-PFP-DOX holds great promise in simultaneous cancer-targeting ultrasound imaging and ultrasound- mediated delivery for cancer chemotherapy.

Black plasma-sprayed Ta2O5 coatings with photothermal effect for bone tumor therapy

2018 ◽  
Vol 44 (11) ◽  
pp. 12002-12006 ◽  
Author(s):  
Ding Ding ◽  
Youtao Xie ◽  
Kai Li ◽  
Liping Huang ◽  
Xuebin Zheng
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
Plasma Sprayed

scholarly journals Bifunctional, Copper-Doped, Mesoporous Silica Nanosphere-Modified, Bioceramic Scaffolds for Bone Tumor Therapy

2020 ◽  
Vol 8 ◽  
Author(s):  
Hongshi Ma ◽  
Zhenjiang Ma ◽  
Qufei Chen ◽  
Wentao Li ◽  
Xiangfei Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Checkpoint Inhibitors ◽  
Tumor Therapy ◽  
Residual Tumor ◽  
Bone Defects ◽  
Silica Nanosphere ◽  
Large Bone ◽  
Large Bone Defects

In the traditional surgical intervention procedure, residual tumor cells may potentially cause tumor recurrence. In addition, large bone defects caused by surgery are difficult to self-repair. Thus, it is necessary to design a bioactive scaffold that can not only kill residual tumor cells but also promote bone defect regeneration simultaneously. Here, we successfully developed Cu-containing mesoporous silica nanosphere-modified β-tricalcium phosphate (Cu-MSN-TCP) scaffolds, with uniform and dense nanolayers with spherical morphology via 3D printing and spin coating. The scaffolds exhibited coating time- and laser power density-dependent photothermal performance, which favored the effective killing of tumor cells under near-infrared laser irradiation. Furthermore, the prepared scaffolds favored the proliferation and attachment of rabbit bone marrow-derived mesenchymal stem cells and stimulated the gene expression of osteogenic markers. Overall, Cu-MSN-TCP scaffolds can be considered for complete eradication of residual bone tumor cells and simultaneous healing of large bone defects, which may provide a novel and effective strategy for bone tumor therapy. In the future, such Cu-MSN-TCP scaffolds may function as carriers of anti-cancer drugs or immune checkpoint inhibitors in chemo-/photothermal or immune-/photothermal therapy of bone tumors, favoring for effective treatment.

A Novel Chitosan Microbubble as Ultrasound-Triggered Drug Carrier for Antitumor In Vitro

2014 ◽  
Vol 636 ◽  
pp. 139-143
Author(s):  
Song Shen ◽  
Bei Ding ◽  
Qing Li ◽  
Xu Wei Yu ◽  
Xue Yong Qi ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan ◽  
Ultrasound Contrast Agents ◽  
Ultrasound Contrast ◽  
Triggered Drug Release ◽  
Ultrasound Assisted ◽  
Potential Strategy

Uniform Microbubbles (MBs) were routinely used as ultrasound contrast agents, but the MBs served for drug carrier showed well-marked advantage. In this study, we prepared a novel docetaxel–loaded microbubbles by carboxymethyl chitosan with W/O/W emulsion technique. Then, the surface morphology was characterized by scanning electron microscope (SEM). Ultrasound-triggered drug release experiments were performed with adjustable intensity and time. In the antitumor experiment in vitro, Ultrasound-assisted drug release from MBs exhibited good treatment of tumor. The results proved the combination of ultrasound and drug-loaded carboxymethyl chitosan microbubbles could be used as a potential strategy for anti-tumor therapy.

Scaffold material sheds light on bone tumor therapy

2018 ◽  
Vol 21 (5) ◽  
pp. 465-466
Author(s):  
Cordelia Sealy
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Scaffold Material

scholarly journals The Development Tendency of 3D-Printed Bioceramic Scaffolds for Applications Ranging From Bone Tissue Regeneration to Bone Tumor Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhixiang Fang ◽  
Jihang Chen ◽  
Jiangxia Pan ◽  
Guoqiang Liu ◽  
Chen Zhao
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tumor ◽  
Physiological Activity ◽  
Tumor Therapy ◽  
Bone Tissue Regeneration ◽  
Tumor Treatment ◽  
3D Printed

Three-dimensional (3D) printing concept has been successfully employed in regenerative medicine to achieve individualized therapy due to its benefit of a rapid, accurate, and predictable production process. Traditional biocomposites scaffolds (SCF) are primarily utilised for bone tissue engineering; nevertheless, over the last few years, there has already been a dramatic shift in the applications of bioceramic (BCR) SCF. As a direct consequence, this study focused on the structural, degeneration, permeation, and physiological activity of 3D-printed BCR (3DP-B) SCF with various conformations and work systems (macros, micros, and nanos ranges), as well as their impacts on the mechanical, degeneration, porosity, and physiological activities. In addition, 3DP-B SCF are highlighted in this study for potential uses applied from bone tissue engineering (BTE) to bone tumor treatment. The study focused on significant advances in practical 3DP-B SCF that can be utilized for tumor treatment as well as bone tissue regeneration (BTR). Given the difficulties in treating bone tumors, these operational BCR SCF offer a lot of promise in mending bone defects caused by surgery and killing any remaining tumor cells to accomplish bone tumor treatment. Furthermore, a quick assessment of future developments in this subject was presented. The study not only summarizes recent advances in BCR engineering, but it also proposes a new therapeutic strategy focused on the extension of conventional ceramics’ multifunction to a particular diagnosis.

Corrigendum to “3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy” [Acta Biomater. 73 (2018) 531–546]

2019 ◽  
Vol 89 ◽  
pp. 421-424 ◽  
Author(s):  
Yaqin Liu ◽  
Tao Li ◽  
Hongshi Ma ◽  
Dong Zhai ◽  
Cuijun Deng ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
3D Printed

Progress of biomaterials for bone tumor therapy

2021 ◽  
pp. 088532822110352
Author(s):  
Hanzheng Chen ◽  
Yongchang Yao
Keyword(s):  
Bone Tumor ◽  
Bone Tumors ◽  
Clinical Medicine ◽  
Surgical Intervention ◽  
Low Cost ◽  
Tumor Therapy ◽  
Bone Defects ◽  
Interdisciplinary Cooperation ◽  
Tumor Treatment ◽  
Clinical Challenge

Bone tumors are currently a major clinical challenge. In recent decades, strategies using well-designed versatile biomaterials for the treatment of bone tumors have emerged and attracted extensive research interest. Suitable biomaterials not only facilitate repair for bone defects aroused by surgical intervention but also help deliver antineoplastic drugs to the target site or provide photothermal/magnetothermal therapy to kill bone tumor cells. Thus, the development of biomaterials exhibits a great perspective for future bone tumor treatment. We summarize the recent progress of versatile biomaterials for bone tumor therapy, with an emphasis on photothermal/magnetothermal therapy and drug delivery. With the further understanding and development of biomaterials, multifunctional biomaterials have been proposed for bone tumor treatment. Through the interdisciplinary cooperation from the fields of biomedicine, clinical medicine and engineering, multifunctional biomaterials will perfectly match individual bone defects in the clinic with low cost in the future.

3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy

2018 ◽  
Vol 73 ◽  
pp. 531-546 ◽  
Author(s):  
Yaqin Liu ◽  
Tao Li ◽  
Hongshi Ma ◽  
Dong Zhai ◽  
Cuijun Deng ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
3D Printed
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